The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila
Open accessAbstract
In vitro experiments suggest that glycosaminoglycans (GAGs) and the proteins to which they are attached (proteoglycans) are important for modulating growth factor signaling. However, in vivo evidence to support this view has been lacking, in part because mutations that disrupt the production of GAG polymers and the core proteins have not been available. Here we describe the identification and characterization of Drosophila mutants in the suppenkasper (ska) gene. The ska gene encodes UDP-glucose dehydrogenase which produces glucuronic acid, an essential component for the synthesis of heparan and chondroitin sulfate. ska mutants fail to put heparan side chains on proteoglycans such as Syndecan. Surprisingly, mutant embryos produced by germ-line clones of this general metabolic gene exhibit embryonic cuticle phenotypes strikingly similar to those that result from loss-of-function mutations in genes of the Wingless (Wg) signaling pathway. Zygotic loss of ska leads to reduced growth of imaginal discs and pattern defects similar to wg mutants. In addition, genetic interactions of ska with wg and dishevelled mutants are observed. These data demonstrate the importance of proteoglycans and GAGs in Wg signaling in vivo and suggest that Wnt-like growth factors may be particularly sensitive to perturbations of GAG biosynthesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Schweitzer, R., Shaharabany, M., Seger, R., & Shilo, B. Z. (1995) · Genes & Development · doi:10.1101/gad.9.12.1518 · Cited by 317
Cited by
Functions of Cell Surface Heparan Sulfate Proteoglycans
Bernfield, M., Götte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J., & Zako, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.729 · Cited by 2,688
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate
Esko, J. D., & Selleck, S. B. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135458 · Cited by 1,495
Functions of heparan sulfate proteoglycans in cell signaling during development
Lin, X. (2004) · Development · doi:10.1242/dev.01522 · Cited by 678
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632
Kispert, A., Vainio, S., & McMahon, A. P. (1998) · Development · doi:10.1242/dev.125.21.4225 · Cited by 522
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
Forsberg, E., Pejler, G., Ringvall, M., Lunderius, C., Tomasini-Johansson, B., Kusche-Gullberg, M., Eriksson, I., Ledin, J., Hellman, L., & Kjellén, L. (1999) · Nature · doi:10.1038/23488 · Cited by 481
Bullock, S. L., Fletcher, J. M., Beddington, R. S. P., & Wilson, V. A. (1998) · Genes & Development · doi:10.1101/gad.12.12.1894 · Cited by 455
Expression of CD44 in Apc and TcfMutant Mice Implies Regulation by the WNT Pathway
Wielenga, V. J. M., Smits, R., Korinek, V., Smit, L., Kielman, M., Fodde, R., Clevers, H., & Pals, S. T. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65297-2 · Cited by 433
Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions
Tumova, S., Woods, A., & Couchman, J. R. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00116-8 · Cited by 375
Baeg, G.-H., Lin, X., Khare, N., Baumgartner, S., & Perrimon, N. (2001) · Development · doi:10.1242/dev.128.1.87 · Cited by 371
Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice
Alexander, C. M., Reichsman, F., Hinkes, M. T., Lincecum, J., Becker, K. A., Cumberledge, S., & Bernfield, M. (2000) · Nature Genetics · doi:10.1038/77108 · Cited by 305
UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish
Walsh, E. C., & Stainier, D. Y. R. (2001) · Science · doi:10.1126/science.293.5535.1670 · Cited by 289
Toyoda, H., Kinoshita-Toyoda, A., & Selleck, S. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2269 · Cited by 287
Ringvall, M., Ledin, J., Holmborn, K., van Kuppevelt, T., Ellin, F., Eriksson, I., Olofsson, A.-M., Kjellén, L., & Forsberg, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000359200 · Cited by 217
Zhu, X., Sen, J., Stevens, L., Goltz, J. S., & Stein, D. (2005) · Development · doi:10.1242/dev.01962 · Cited by 37
Chemistry and Function of Glycosaminoglycans in the Nervous System
Schwartz, N. B., & Domowicz, M. S. (2014) · Advances in Neurobiology · doi:10.1007/978-1-4939-1154-7_5 · Cited by 25
Metadata
- Authors
- Haerry, T. E., Heslip, T. R., Marsh, J. L., & O’Connor, M. B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-08-15
- Volume
- 124
- Issue
- 16
- Pages
- 3055-3064
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2169483492
- Cited by
- 194
- References
- 2
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
