The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells
Abstract
The mushroom body (MB) is an important centre for higher order sensory integration and learning in insects. To analyse the development and organisation of the MB neuropile in Drosophila, we performed cell lineage analysis in the adult brain with a new technique that combines the Flippase (flp)/FRT system and the GAL4/UAS system. We showed that the four mushroom body neuroblasts (MBNbs) give birth exclusively to the neurones and glial cells of the MB, and that each of the four MBNb clones contributes to the entire MB structure. The expression patterns of 19 GAL4 enhancer-trap strains that mark various subsets of MB cells revealed overlapping cell types in all four of the MBNb lineages. Partial ablation of MBNbs using hydroxyurea showed that each of the four neuroblasts autonomously generates the entire repertoire of the known MB substructures.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Learning representations by back-propagating errors
Rumelhart, D. E., Hinton, G. E., & Williams, R. J. (1986) · Nature · doi:10.1038/323533a0 · Cited by 31,892
Cited by
Pamudurti, N. R., Bartok, O., Jens, M., Ashwal-Fluss, R., Stottmeister, C., Ruhe, L., Hanan, M., Wyler, E., Perez-Hernandez, D., Ramberger, E., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.021 · Cited by 1,810
A connectome and analysis of the adult Drosophila central brain
Scheffer, L. K., Xu, C. S., Januszewski, M., Lu, Z., Takemura, S.-Y., Hayworth, K. J., Huang, G. B., Shinomiya, K., Maitlin-Shepard, J., Berg, S., et al. (2020) · eLife · doi:10.7554/elife.57443 · Cited by 1,128
Self-citationThe neuronal architecture of the mushroom body provides a logic for associative learning
Aso, Y., Hattori, D., Yu, Y., Johnston, R. M., Iyer, N. A., Ngo, T.-T., Dionne, H., Abbott, L., Axel, R., Tanimoto, H., et al. (2014) · eLife · doi:10.7554/elife.04577 · Cited by 1,051
Akt regulates growth by directly phosphorylating Tsc2
Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959
A Genetic Screen in Drosophila for Metastatic Behavior
Pagliarini, R. A., & Xu, T. (2003) · Science · doi:10.1126/science.1088474 · Cited by 543
Neuronal assemblies of the Drosophila mushroom body
Tanaka, N. K., Tanimoto, H., & Ito, K. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21692 · Cited by 470
Self-citationDaughters against dpp modulates dpp organizing activity in Drosophila wing development
Tsuneizumi, K., Nakayama, T., Kamoshida, Y., Kornberg, T. B., Christian, J. L., & Tabata, T. (1997) · Nature · doi:10.1038/39362 · Cited by 429
A connectome of a learning and memory center in the adult Drosophila brain
Takemura, S.-Y., Aso, Y., Hige, T., Wong, A., Lu, Z., Xu, C. S., Rivlin, P. K., Hess, H., Zhao, T., Parag, T., et al. (2017) · eLife · doi:10.7554/elife.26975 · Cited by 367
Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics
Croset, V., Treiber, C. D., & Waddell, S. (2018) · eLife · doi:10.7554/elife.34550 · Cited by 299
Asymmetric Localization of Frizzled and the Establishment of Cell Polarity in the Drosophila Wing
Strutt, D. I. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00184-8 · Cited by 334
Otsuna, H., & Ito, K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21015 · Cited by 224
Self-citationKamikouchi, A., Shimada, T., & Ito, K. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.21075 · Cited by 220
Self-citationTanentzapf, G., Smith, C., McGlade, J., & Tepass, U. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.891 · Cited by 199
Systematic analysis of neural projections reveals clonal composition of the Drosophila brain
Ito, M., Masuda, N., Shinomiya, K., Endo, K., & Ito, K. (2013) · Current Biology · doi:10.1016/j.cub.2013.03.015 · Cited by 166
Self-citationTesting Odor Response Stereotypy in the Drosophila Mushroom Body
Murthy, M., Fiete, I., & Laurent, G. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.040 · Cited by 163
Clonal Development and Organization of the Adult Drosophila Central Brain
Yu, H.-H., Awasaki, T., Schroeder, M. D., Long, F., Yang, J. S., He, Y., Ding, P., Kao, J.-C., Wu, G. Y.-Y., Peng, H., et al. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.057 · Cited by 163
Gamma‐aminobutyric acid (GABA)‐mediated neural connections in the Drosophila antennal lobe
Okada, R., Awasaki, T., & Ito, K. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21971 · Cited by 146
Self-citationTopological and modality-specific representation of somatosensory information in the fly brain
Tsubouchi, A., Yano, T., Yokoyama, T. K., Murtin, C., Otsuna, H., & Ito, K. (2017) · Science · doi:10.1126/science.aan4428 · Cited by 108
Self-citationFoxP influences the speed and accuracy of a perceptual decision in Drosophila
DasGupta, S., Ferreira, C. H., & Miesenböck, G. (2014) · Science · doi:10.1126/science.1252114 · Cited by 104
Miyazaki, T., & Ito, K. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22433 · Cited by 83
Self-citationKim, S., Wairkar, Y. P., Daniels, R. W., & DiAntonio, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911126 · Cited by 82
Structured sampling of olfactory input by the fly mushroom body
Zheng, Z., Li, F., Fisher, C., Ali, I. J., Sharifi, N., Calle-Schuler, S., Hsu, J., Masoodpanah, N., Kmecova, L., Kazimiers, T., et al. (2022) · Current Biology · doi:10.1016/j.cub.2022.06.031 · Cited by 75
PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells
McDonald, J. A., Khodyakova, A., Aranjuez, G., Dudley, C., & Montell, D. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.09.041 · Cited by 63
Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development
Zeng, Y. A., & Verheyen, E. M. (2004) · Development · doi:10.1242/dev.01177 · Cited by 60
Lovick, J. K., Ngo, K. T., Omoto, J. J., Wong, D. C., Nguyen, J. D., & Hartenstein, V. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.07.008 · Cited by 48
Wong, D. C., Lovick, J. K., Ngo, K. T., Borisuthirattana, W., Omoto, J. J., & Hartenstein, V. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.07.009 · Cited by 46
Papadopoulos, D. K., Skouloudaki, K., Engström, Y., Terenius, L., Rigler, R., Zechner, C., Vukojević, V., & Tomancak, P. (2019) · Development · doi:10.1242/dev.168179 · Cited by 41
Wittkorn, E., Sarkar, A., Garcia, K., Kango-Singh, M., & Singh, A. (2015) · Development · doi:10.1242/dev.117358 · Cited by 39
Hartenstein, V., Omoto, J. J., Ngo, K. T., Wong, D., Kuert, P. A., Reichert, H., Lovick, J. K., & Younossi‐Hartenstein, A. (2018) · Journal of Comparative Neurology · doi:10.1002/cne.24287 · Cited by 31
Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila
Seeds, A. M., Tsui, M. M., Sunu, C., Spana, E. P., & York, J. D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514684112 · Cited by 21
Yorkie-Cactus (IκBα)-JNK axis promotes tumor growth and progression in Drosophila
Snigdha, K., Singh, A., & Kango-Singh, M. (2021) · Oncogene · doi:10.1038/s41388-021-01831-4 · Cited by 11
Metadata
- Authors
- Ito, K., Awano, W., Suzuki, K., Hiromi, Y., & Yamamoto, D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-02-15
- Volume
- 124
- Issue
- 4
- Pages
- 761-771
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2184390227
- Cited by
- 757
- References
- 1
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
