The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors
Abstract
The lineage of olfactory neurons has been relatively well characterized at the cellular level, but the genes that regulate the proliferation and differentiation of their progenitors are currently unknown. In this study, we report the isolation of a novel murine gene, Math4C/neurogenin1, which is distantly related to the Drosophila proneural gene atonal. We show that Math4C/neurogenin1 and the basic helix-loop-helix gene Mash1 are expressed in the olfactory epithelium by different dividing progenitor populations, while another basic helix-loop-helix gene, NeuroD, is expressed at the onset of neuronal differentiation. These expression patterns suggest that each gene marks a distinct stage of olfactory neuron progenitor development, in the following sequence: Mash1>Math4C/neurogenin1>NeuroD. We have previously reported that inactivation of Mash1 function leads to a severe reduction in the number of olfactory neurons. We show here that most cells in the olfactory epithelium of Mash1 mutant embryos fail to express Math4C/neurogenin1 or NeuroD. Strikingly, a subset of progenitor cells in a ventrocaudal domain of Mash1 mutant olfactory epithelium still express Math4C/neurogenin1 and NeuroD and differentiate into neurons. Cells in this domain also express Math4A/neurogenin2, another member of the Math4/neurogenin gene family, and not Mash1. Our results demonstrate that Mash1 is required at an early stage in the olfactory neuron lineage to initiate a differentiation program involving Math4C/neurogenin1 and NeuroD. Another gene activates a similar program in a separate population of olfactory neuron progenitors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
Cited by
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F., & Kageyama, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2196 · Cited by 852
Self-citationNeurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.
Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M. Z., Zubiaga, A., Hua, X., Fan, G., & Greenberg, M. E. (2001) · Cell · doi:10.1016/s0092-8674(01)00224-0 · Cited by 681
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
Schwitzgebel, V. M., Scheel, D. W., Conners, J. R., Kalamaras, J., Lee, J. E., Anderson, D. J., Sussel, L., Johnson, J. D., & German, M. S. (2000) · Development · doi:10.1242/dev.127.16.3533 · Cited by 678
Fode, C., Ma, Q., Casarosa, S., Ang, S.-L., Anderson, D. J., & Guillemot, F. (2000) · Genes & Development · doi:10.1101/gad.14.1.67 · Cited by 624
Self-citationOrigin and Molecular Specification of Striatal Interneurons
Marı́n, O., Anderson, S. A., & Rubenstein, J. L. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06063.2000 · Cited by 631
Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.081 · Cited by 503
Fode, C., Gradwohl, G., Morin, X., Dierich, A., LeMeur, M., Goridis, C., & Guillemot, F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80989-7 · Cited by 444
Self-citationIdentification and characterization of rod-derived cone viability factor
Léveillard, T., Mohand-Saïd, S., Lorentz, O., Hicks, D., Fintz, A.-C., Clérin, E., Simonutti, M., Forster, V., Cavusoglu, N., Chalmel, F., et al. (2004) · Nature Genetics · doi:10.1038/ng1386 · Cited by 438
Jacquemin, P., Durviaux, S. M., Jensen, J., Godfraind, C., Gradwohl, G., Guillemot, F., Madsen, O. D., Carmeliet, P., Dewerchin, M., Collen, D., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4445-4454.2000 · Cited by 326
Self-citationThe Proneural Basic Helix-Loop-Helix Gene Ascl1a Is Required for Retina Regeneration
Fausett, B. V., Gumerson, J. D., & Goldman, D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4853-07.2008 · Cited by 251
Wallis, D., Hamblen, M., Zhou, Y., Venken, K. J. T., Schumacher, A., Grimes, H. L., Zoghbi, H. Y., Orkin, S. H., & Bellen, H. J. (2003) · Development · doi:10.1242/dev.00190 · Cited by 264
Single-Cell Transcriptional Analysis of Neuronal Progenitors
Tietjen, I., Rihel, J. M., Cao, Y., Koentges, G., Zakhary, L., & Dulac, C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00229-0 · Cited by 260
Neurogenin 2 has an essential role in development of the dentate gyrus
Galichet, C., Guillemot, F., & Parras, C. M. (2008) · Development · doi:10.1242/dev.015115 · Cited by 108
Self-citationLin, B., Coleman, J. H., Peterson, J. N., Zunitch, M. J., Jang, W., Herrick, D. B., & Schwob, J. E. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.09.008 · Cited by 90
A Short History of Nearly Every Sense—The Evolutionary History of Vertebrate Sensory Cell Types
Schlosser, G. (2018) · Integrative and Comparative Biology · doi:10.1093/icb/icy024 · Cited by 33
Metadata
- Authors
- Cau, E., Gradwohl, G., Fode, C., & Guillemot, F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-04-15
- Volume
- 124
- Issue
- 8
- Pages
- 1611-1621
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2151792462
- Cited by
- 404
- References
- 1
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
