The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Hedgehog signals regulate multiple aspects of gastrointestinal development
Abstract
The gastrointestinal tract develops from the embryonic gut, which is composed of an endodermally derived epithelium surrounded by cells of mesodermal origin. Cell signaling between these two tissue layers appears to play a critical role in coordinating patterning and organogenesis of the gut and its derivatives. We have assessed the function of Sonic hedgehog and Indian hedgehog genes, which encode members of the Hedgehog family of cell signals. Both are expressed in gut endoderm, whereas target genes are expressed in discrete layers in the mesenchyme. It was unclear whether functional redundancy between the two genes would preclude a genetic analysis of the roles of Hedgehog signaling in the mouse gut. We show here that the mouse gut has both common and separate requirements for Sonic hedgehog and Indian hedgehog. Both Sonic hedgehog and Indian hedgehog mutant mice show reduced smooth muscle, gut malrotation and annular pancreas. Sonic hedgehog mutants display intestinal transformation of the stomach, duodenal stenosis (obstruction), abnormal innervation of the gut and imperforate anus. Indian hedgehog mutants show reduced epithelial stem cell proliferation and differentiation, together with features typical of Hirschsprung’s disease (aganglionic colon). These results show that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations.
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Cites
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
Self-citationInsulin-promoter-factor 1 is required for pancreas development in mice
Jonsson, J., Carlsson, L., Edlund, T., & Edlund, H. (1994) · Nature · doi:10.1038/371606a0 · Cited by 1,785
St-Jacques, B., Hammerschmidt, M., & McMahon, A. P. (1999) · Genes & Development · doi:10.1101/gad.13.16.2072 · Cited by 1,735
Self-citationDepletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P. J., & Clevers, H. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,581
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. M., & Wright, C. V. E. (1996) · Development · doi:10.1242/dev.122.3.983 · Cited by 1,513
Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370
Self-citationMutations in the human Sonic Hedgehog gene cause holoprosencephaly
Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S. W., Tsui, L.-C., & Muenke, M. (1996) · Nature Genetics · doi:10.1038/ng1196-357 · Cited by 1,152
Krauss, S., Concordet, J.-P., & Ingham, P. W. (1993) · Cell · doi:10.1016/0092-8674(93)90628-4 · Cited by 1,070
Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90397-6 · Cited by 887
Cited by
Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
van der Flier, L. G., & Clevers, H. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,871
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
Berman, D. M., Karhadkar, S. S., Maitra, A., Montes de Oca, R., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., et al. (2003) · Nature · doi:10.1038/nature01972 · Cited by 1,251
Tissue repair and stem cell renewal in carcinogenesis
Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004) · Nature · doi:10.1038/nature03100 · Cited by 1,208
Wang, K., Yuen, S. T., Xu, J., Lee, S. P., Yan, H. H. N., Shi, S. T., Siu, H. C., Deng, S., Chu, K. M., Law, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.2983 · Cited by 1,045
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Self-citationInflammation, atrophy, and gastric cancer
Fox, J. G., & Wang, T. C. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30111 · Cited by 772
Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
A bipotential precursor population for pancreas and liver within the embryonic endoderm
Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611
Zhang, X. M., Ramalho-Santos, M., & McMahon, A. P. (2001) · Cell · doi:10.1016/s0092-8674(01)00385-3 · Cited by 606
Self-citationMechanisms and functions of Hedgehog signalling across the metazoa
Ingham, P. W., Nakano, Y., & Seger, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2984 · Cited by 605
Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells
Lum, L., Yao, S., Mozer, B., Rovescalli, A., Von Kessler, D., Nirenberg, M., & Beachy, P. A. (2003) · Science · doi:10.1126/science.1081403 · Cited by 532
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
Sancho, E., Batlle, E., & Clevers, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.092805 · Cited by 532
Heanue, T. A., & Pachnis, V. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2137 · Cited by 527
Intestinal growth and differentiation in zebrafish
Wallace, K. N., Akhter, S., Smith, E. M., Lorent, K., & Pack, M. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2004.10.009 · Cited by 526
Regulation of pancreas development by hedgehog signaling
Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412
Self-citationPulmonary-intestinal cross-talk in mucosal inflammatory disease
Keely, S., Talley, N. J., & Hansbro, P. M. (2012) · Mucosal Immunology · doi:10.1038/mi.2011.55 · Cited by 386
Epithelial hedgehog signals pattern the intestinal crypt-villus axis
Madison, B. B., Braunstein, K., Kuizon, E., Portman, K., Qiao, X. T., & Gumucio, D. L. (2005) · Development · doi:10.1242/dev.01576 · Cited by 377
Kusano, K. F., Pola, R., Murayama, T., Curry, C., Kawamoto, A., Iwakura, A., Shintani, S., Ii, M., Asai, J., Tkebuchava, T., et al. (2005) · Nature Medicine · doi:10.1038/nm1313 · Cited by 304
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
van den Brink, G. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00054.2006 · Cited by 301
Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis
Olson, L. E., & Soriano, P. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.12.003 · Cited by 264
Hedgehog is required for murine yolk sac angiogenesis
Byrd, N., Becker, S., Maye, P., Narasimhaiah, R., St-Jacques, B., Zhang, X., McMahon, J., McMahon, A., & Grabel, L. (2002) · Development · doi:10.1242/dev.129.2.361 · Cited by 257
Self-citationGlobal expression analysis of gene regulatory pathways during endocrine pancreatic development
Gu, G., Wells, J. M., Dombkowski, D., Preffer, F., Aronow, B., & Melton, D. A. (2004) · Development · doi:10.1242/dev.00921 · Cited by 229
Self-citationLi, Z., Yu, T., Morishima, M., Pao, A., LaDuca, J., Conroy, J., Nowak, N., Matsui, S.-I., Shiraishi, I., & Yu, Y. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm086 · Cited by 218
Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas
Fendrich, V., Esni, F., Garay, M. V. R., Feldmann, G., Habbe, N., Jensen, J. N., Dor, Y., Stoffers, D., Jensen, J., Leach, S. D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.011 · Cited by 191
Building a brain in the gut: development of the enteric nervous system
Goldstein, A., Hofstra, R., & Burns, A. (2013) · Clinical Genetics · doi:10.1111/cge.12054 · Cited by 183
Stomach development, stem cells and disease
Kim, T.-H., & Shivdasani, R. A. (2016) · Development · doi:10.1242/dev.124891 · Cited by 175
Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function
Lewis, S. L., & Tam, P. P. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20846 · Cited by 164
Le Guen, L., Marchal, S., Faure, S., & de Santa Barbara, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1975-2 · Cited by 95
Metadata
- Authors
- Ramalho-Santos, M., Melton, D. A., & McMahon, A. P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-06-15
- Volume
- 127
- Issue
- 12
- Pages
- 2763-2772
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2152349982
- Cited by
- 845
- References
- 51
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- closed
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