The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless
Abstract
Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene dally in this process. Here, we report the identification of another Drosophila glypican gene, dally-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper glycosaminoglycan biosynthesis. We conclude that HSPGs play an important role in organizing the extracellular distribution of Wg.
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Citations
Cites
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Metadata
- Authors
- Baeg, G.-H., Lin, X., Khare, N., Baumgartner, S., & Perrimon, N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-01-01
- Volume
- 128
- Issue
- 1
- Pages
- 87-94
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2108345995
- Cited by
- 371
- References
- 48
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
