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Cited by 371

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

Baeg, Gyeong-Hun, Lin, Xinhua, Khare, Narmada, Baumgartner, Stefan, Perrimon, Norbert·2001·Development
DOI 10.1242/dev.128.1.87
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Abstract

Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene dally in this process. Here, we report the identification of another Drosophila glypican gene, dally-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper glycosaminoglycan biosynthesis. We conclude that HSPGs play an important role in organizing the extracellular distribution of Wg.

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Metadata

Authors
Baeg, G.-H., Lin, X., Khare, N., Baumgartner, S., & Perrimon, N.
Venue
Development
Publisher
The Company of Biologists
Published
2001-01-01
Volume
128
Issue
1
Pages
87-94
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.128.1.87
OpenAlex
W2108345995
Cited by
371
References
48
FWCI
11.52
Type
journal article
Language
en
Open access
closed

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