Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification

Defining the Epithelial Stem Cell Niche in Skin

Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031

Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche

Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

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Three clonal types of keratinocyte with different capacities for multiplication.

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Capturing and profiling adult hair follicle stem cells

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Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

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Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta.

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Endoreplication Cell Cycles

Edgar, B. A., & Orr‐Weaver, T. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00334-8 · Cited by 843

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823

Drosophila myc Regulates Cellular Growth during Development

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Drosophila Myc Regulates Organ Size by Inducing Cell Competition

de la Cova, C., Abril, M., Bellosta, P., Gallant, P., & Johnston, L. A. (2004) · Cell · doi:10.1016/s0092-8674(04)00214-4 · Cited by 610

dMyc Transforms Cells into Super-Competitors

Moreno, E., & Basler, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00262-4 · Cited by 597

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.Preprint

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Direct activation of RNA polymerase III transcription by c-Myc

Gomez-Roman, N., Grandori, C., Eisenman, R. N., & White, R. J. (2003) · Nature · doi:10.1038/nature01327 · Cited by 434

c-Myc regulates mammalian body size by controlling cell number but not cell size

Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434

Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

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Analysis of C-MYC Function in Normal Cells via Conditional Gene-Targeted Mutation

de Alborán, I. M., O’Hagan, R. C., Gärtner, F., Malynn, B. A., Davidson, L., Rickert, R. C., Rajewsky, K., DePinho, R. A., & Alt, F. W. (2001) · Immunity · doi:10.1016/s1074-7613(01)00088-7 · Cited by 398

Involucrin synthesis and tissue assembly by keratinocytes in natural and cultured human epithelia.

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Plant cell-size control: growing by ploidy?

Kondorosi, É., Roudier, F., & Gendreau, E. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)00118-7 · Cited by 348

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

Arnold, I., & Watt, F. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00154-3 · Cited by 341

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiationPreprint

Malynn, B. A., de Alborán, I. M., O’Hagan, R. C., Bronson, R. T., Davidson, L., DePinho, R. A., & Alt, F. W. (2000) · Genes & Development · doi:10.1101/gad.14.11.1390 · Cited by 331

c-Myc promotes differentiation of human epidermal stem cells

Gandarillas, A., & Watt, F. M. (1997) · Genes & Development · doi:10.1101/gad.11.21.2869 · Cited by 326

Deregulated expression of c-Myc depletes epidermal stem cells

Waikel, R. L., Kawachi, Y., Waikel, P. A., Wang, X.-J., & Roop, D. R. (2001) · Nature Genetics · doi:10.1038/88889 · Cited by 318

Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain

Mao, X., Fujiwara, Y., Chapdelaine-Williams, A. M., Yang, H., & Orkin, S. H. (2001) · Blood · doi:10.1182/blood.v97.1.324 · Cited by 291

Terminal differentiation of epidermal keratinocytes

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Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

Sellheyer, K., Bickenbach, J. R., Rothnagel, J. A., Bundman, D. S., Longley, M. A., Krieg, T. M., Roche, N. S., Roberts, A. B., & Roop, D. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5237 · Cited by 254

Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

Ramı́rez, Á., Bravo, A., Jorcano, J. L., & Vidal, M. (1994) · Differentiation · doi:10.1046/j.1432-0436.1994.5810053.x · Cited by 206

p63 and the epithelial stem cell: more than status quo?Preprint

McKeon, F. (2004) · Genes & Development · doi:10.1101/gad.1190504 · Cited by 198

A keratin K5Cre transgenic line appropriate for tissue‐specific or generalized cre‐mediated recombination

Ramı́rez, Á., Page, A., Gandarillas, A., Zanet, J., Pibre, S., Vidal, M., Tusell, L., Genescà, A., Whitaker, D. A., Melton, D. W., et al. (2004) · genesis · doi:10.1002/gene.20025 · Cited by 190

Endoreduplication and development: rule without dividing?

Traas, J. A., Hülskamp, M., Gendreau, E., & Höfte, H. (1998) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(98)80042-3 · Cited by 190

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

Frye, M., Gardner, C., Li, E. R., Arnold, I., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00462 · Cited by 187

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

Kim, S., Li, Q., Dang, C. V., & Lee, L. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200372597 · Cited by 187

Myc and Max Homologs in Drosophila

Gallant, P., Shiio, Y., Cheng, P. F., Parkhurst, S. M., & Eisenman, R. N. (1996) · Science · doi:10.1126/science.274.5292.1523 · Cited by 176

dMyc is required for larval growth and endoreplication in Drosophila

Pierce, S. B., Yost, C., Britton, J. S., Loo, L. W. M., Flynn, E. M., Edgar, B. A., & Eisenman, R. N. (2004) · Development · doi:10.1242/dev.01108 · Cited by 163

Developmental Context Determines Latency of MYC-Induced Tumorigenesis

Beer, S., Zetterberg, A., Ihrie, R. A., McTaggart, R., Yang, Q., Bradon, N., Arvanitis, C., Attardi, L. D., Feng, S., Ruebner, B. H., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020332 · Cited by 142

C-myc overexpression and p53 loss cooperate to promote genomic instability

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Disentangling the MYC web

Levens, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102173199 · Cited by 120

Drosophila dMyc is required for ovary cell growth and endoreplication

Maines, J. Z., Stevens, L. M., Tong, X., & Stein, D. (2004) · Development · doi:10.1242/dev.00932 · Cited by 110

c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver

Baena, E., Gandarillas, A., Vallespinós, M., Zanet, J., Bachs, O., Redondo, C., Fabregat, I., Martinez-A., C., & de Alborán, I. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409260102 · Cited by 104

Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype

Schreiber‐Agus, N., Stein, D., Chen, K., Goltz, J. S., Stevens, L. M., & DePinho, R. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1235 · Cited by 100

Label-retaining keratinocytes and Langerhans cells in mouse epithelia

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Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication

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Contrasting roles for c‐Myc and L‐Myc in the regulation of cellular growth and differentiation in vivo.

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Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation

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Congenital contractures, edema, hyperkeratosis, and intrauterine growth retardation: A fatal syndrome in hutterite and mennonite kindreds

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B-Myc Inhibits Neoplastic Transformation and Transcriptional Activation by c-Myc

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Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family

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Historical note on restrictive dermopathy and report of two new cases

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Lower Extremity Purpura

Berlin, J. M., & Queen, J. R. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.6.831 · Cited by 3

Tight Skin and Dysmorphic Features in a Newborn

Abrahamson, T. G., & Stone, M. S. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.6.831-c · Cited by 1

Scratching the surface of skin development

Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930

Epidermal Stem Cells of the Skin

Blanpain, C., & Fuchs, E. V. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 882

MYC, Metabolism, Cell Growth, and TumorigenesisPreprint

Dang, C. V. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014217 · Cited by 625

Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland

Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., & Fuchs, E. (2006) · Cell · doi:10.1016/j.cell.2006.06.048 · Cited by 426

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence

Jensen, K. B., & Watt, F. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601886103 · Cited by 321

MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation

Nascimento, E. M. (2011) · Apollo (University of Cambridge) · doi:10.17863/cam.16482

Analysis of c-Myc function in mouse epidermis

Óskarsson, T. (2005) · IRIS

c-Myc promotes differentiation of human epidermal stem cells

Gandarillas, A., & Watt, F. M. (1997) · Genes & Development · doi:10.1101/gad.11.21.2869 · Cited by 326

c-Myc regulates mammalian body size by controlling cell number but not cell size

Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

Arnold, I., & Watt, F. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00154-3 · Cited by 341