Cited by 123Hair Growth and DisordersSkin and Cellular Biology ResearchDevelopmental Biology and Gene Regulation

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Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification

Zanet, Jennifer, Pibre, Sophie, Jacquet, Chantal, Ramirez, Angel, de Alborán, Ignacio Moreno, Gandarillas, Alberto·2005·Journal of Cell Science

DOI 10.1242/jcs.02298

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Abstract

The transcription factor Myc (c-Myc) plays an important role in cell growth and cell death, yet its physiological function remains unclear. Ectopic activation of Myc has been recently suggested to regulate cell mass, and Drosophila dmyc controls cellular growth and size independently of cell division. By contrast, it has been proposed that in mammals Myc controls cell division and cell number. To gain insights into this debate we have specifically knocked out Myc in epidermis. Myc epidermal knockout mice are viable and their keratinocytes continue to cycle, but they display severe skin defects. The skin is tight and fragile, tears off in areas of mechanical friction and displays impaired wound healing. Steady-state epidermis is thinner, with loss of the proliferative compartment and premature differentiation. Remarkably, keratinocyte cell size, growth and endoreplication are reduced, and stem cell amplification is compromised. The results provide new and direct evidence for a role for endogenous Myc in cellular growth that is required for hyperproliferative cycles and tissue homeostasis.

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Authors: Zanet, J., Pibre, S., Jacquet, C., Ramirez, A., de Alborán, I. M., & Gandarillas, A.
Affiliations: Centre National de la Recherche Scientifique (FR)
Epithelial Damage, Repair and Tissue Engineering Program, CIEMAT, Madrid, Spain
Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
Corresponding author: Gandarillas, Alberto
ORCID: Zanet, Jennifer
Gandarillas, Alberto
Venue: Journal of Cell Science
Publisher: The Company of Biologists
Published: 2005-04-15
Volume: 118
Issue: 8
Pages: 1693-1704
ISSN: 0021-9533 (ISSN-L)
1477-9137
DOI: 10.1242/jcs.02298
OpenAlex: W2101568666
Cited by: 123
References: 50
Citations by year: 2026: 1 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 8 · 2012: 8
FWCI: 12.69
Type: journal article
Language: en
Open access: closed
Locations: Journal of Cell Science (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: c-Myc, epidermis, keratinocytes, cell size, cell growth, endoreplication, hyperproliferation, epidermal stem cells, wound healing, skin defects, tissue homeostasis, cell differentiation
MeSH terms: Animals, Cell Cycle, Cell Differentiation, Cell Division, Cell Movement, Epidermis, Female, Homeostasis, Male, Mice, Transgenic, Ploidies, Stem Cells, Stress, Mechanical, Wound Healing, Keratinocytes, Proto-Oncogene Proteins c-myc, Mice, Knockout, Hair Follicle, Cell Size, Cell Enlargement, Cell Proliferation, Mice

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Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification

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