The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
Open accessAbstract
The secreted Frizzled-related proteins (SFRPs) are a family of soluble proteins that are structurally related to Frizzled (Fz) proteins, the serpentine receptors that mediate the extensively used cell-cell communication pathway involving Wnt signalling. Because of their homology with the Wnt-binding domain on the Fz receptors, SFRPs were immediately characterised as antagonists that bind to Wnt proteins to prevent signal activation. Since these initial studies, interest in the family of SFRPs has grown progressively, offering new perspectives on their function and mechanism of action in both development and disease. These studies indicate that SFRPs are not merely Wnt-binding proteins, but can also antagonise one another's activity, bind to Fz receptors and influence axon guidance, interfere with BMP signalling by acting as proteinase inhibitors, and interact with other receptors or matrix molecules. Furthermore, their expression is altered in different types of cancers, bone pathologies, retinal degeneration and hypophosphatemic diseases, indicating that their activity is fundamental for tissue homeostasis. Here we review some of the debated aspects of SFRP-Wnt interactions and discuss the new and emerging roles of SFRPs.
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Cites
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“Sclerostin and Dickkopf proteins interfere with Wnt activity and antagonise canonical signalling by binding to LRP5 or LRP6, whereas WIF1, Cerberus and SFRPs can interact directly with Wnt proteins (Kawano and Kypta, 2003; Li et al., 2005).”
BackgroundEpigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
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Cited by
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
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Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity
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Metadata
- Authors
- Bovolenta, P., Esteve, P., Ruiz, J. M., Cisneros, E., & Lopez-Rios, J.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2008-03-15
- Volume
- 121
- Issue
- 6
- Pages
- 737-746
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2152567646
- Cited by
- 655
- References
- 116
- FWCI
- 13.52
- Type
- journal article
- Language
- en
- Open access
- green
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