The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A conserved membrane-binding domain targets proteins to organelle contact sites
Open accessAbstract
Membrane contact sites (MCSs), where the membranes of two organelles are closely apposed, are regions where small molecules such as lipids or calcium are exchanged between organelles. We have identified a conserved membrane-binding domain found exclusively in proteins at MCSs in Saccharomyces cerevisiae. The synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain is conserved across species. We show that all seven proteins that contain this domain in yeast localize to one of three MCSs. Human proteins with SMP domains also localize to MCSs when expressed in yeast. The SMP domain binds membranes and is necessary for protein targeting to MCSs. Proteins containing this domain could be involved in lipid metabolism. This is the first protein domain found exclusively in proteins at MCSs.
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Cites
Global analysis of protein localization in budding yeast
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“Nvj2p with GFP at its Cterminus has been previously shown to localize to the ER (Huh et al., 2003), a finding we confirmed (Fig.”
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
Kornmann, B., Currie, E., Collins, S. R., Schuldiner, M., Nunnari, J., Weissman, J. S., & Walter, P. (2009) · Science · doi:10.1126/science.1175088 · Cited by 1,275
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Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018
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Phillips, M. J., & Voeltz, G. K. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.8 · Cited by 933
Organization and Function of Membrane Contact Sites
Helle, S. C. J., Kanfer, G., Kolar, K., Lang, A., Michel, A. H., & Kornmann, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.01.028 · Cited by 453
Murley, A., Lackner, L. L., Osman, C., West, M., Voeltz, G. K., Walter, P., & Nunnari, J. (2013) · eLife · doi:10.7554/elife.00422 · Cited by 326
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A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport
Gatta, A. T., Wong, L. H., Sere, Y. Y., Calderón-Noreña, D. M., Cockcroft, S., Menon, A. K., & Levine, T. P. (2015) · eLife · doi:10.7554/elife.07253 · Cited by 251
In situ architecture of the ER–mitochondria encounter structure
Wozny, M. R., Di Luca, A., Morado, D. R., Picco, A., Khaddaj, R., Campomanes, P., Ivanović, L., Hoffmann, P. C., Miller, E. A., Vanni, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06050-3 · Cited by 134
Localization of Ras signaling complex in budding yeast
Belotti, F., Tisi, R., Paiardi, C., Rigamonti, M., Groppi, S., & Martegani, E. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.04.016 · Cited by 35
Membrane contact sites regulate vacuolar fission via sphingolipid metabolism
Hanaoka, K., Nishikawa, K., Ikeda, A., Schlarmann, P., Sasaki, S., Fujii, S., Yamashita, S., Nakaji, A., & Funato, K. (2024) · eLife · doi:10.7554/elife.89938 · Cited by 6
Membrane contact sites regulate vacuolar fission via sphingolipid metabolism
Hanaoka, K., Nishikawa, K., Ikeda, A., Schlarmann, P., Yamashita, S., Nakaji, A., Fujii, S., & Funato, K. (2023) · doi:10.1101/2023.06.21.546015
Metadata
- Authors
- Toulmay, A., & Prinz, W. A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2012-01-01
- Volume
- 125
- Issue
- 1
- Pages
- 49-58
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2111097328
- Cited by
- 252
- References
- 2
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- green
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