Body Mass Index, but Not Physical Activity, Is Associated with C-Reactive Protein
Abstract
UNLABELLED: Elevated high-sensitivity c-reactive protein (hs-CRP) is associated with increased risk of future first and recurrent coronary events and has been associated with both high body mass index (BMI) and low physical activity in cross sectional studies. PURPOSE: To longitudinally examine the effects of BMI and both current and previous-year physical activity on hs-CRP in healthy men and women (N = 109). METHODS: BMI and hs-CRP were measured five times (baseline and quarterly) over 1 yr. Current physical activity was assessed 12-15 times during the study via 24-h recall. Previous-year physical activity was assessed using the Baecke questionnaire at baseline. RESULTS: Mean BMI and hs-CRP were unchanged over the course of the study, but current physical activity increased on visit 3. Average hs-CRP was not related to average current physical activity or to natural changes in current physical activity across the five visits. Additionally, current physical activity on any given visit was not associated with hs-CRP on the following visit. When current physical activity, BMI, age, gender, and smoking were included in the statistical model, only BMI was significantly related to hs-CRP (P < 0.001). Average hs-CRP was significantly correlated with average BMI (r = 0.50; P < 0.001) but was not related to previous-year (Baecke) physical activity levels (r = 0.02; P = 0.89). When subjects were grouped by BMI (<25 kg.m-2, 25-29.9 kg x m-2, >30 kg x m-2) hs-CRP was significantly greater in obese (3.2 +/- 1.9 mg.L-1) and overweight (2.1 +/- 1.7 mg x L-1) than normal weight (1.1 +/- 1.0 mg.L-1) subjects (ANOVA P < 0.05). Current physical activity was similar between the three BMI groups at all times, and was unrelated to hs-CRP in all groups, throughout the study period. CONCLUSION: These data indicate that BMI, but not previous-year or current physical activity, predicts hs-CRP.
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- Authors
- RAWSON, E. S., FREEDSON, P. S., OSGANIAN, S. K., MATTHEWS, C. E., REED, G., & OCKENE, I. S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Vanderbilt University Medical Center (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2003-07
- Volume
- 35
- Issue
- 7
- Pages
- 1160-1166
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2085846919
- Cited by
- 144
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 9 · 2014: 4 · 2013: 7 · 2012: 13
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- Funders
- National Institutes of Health (5r01hl052745-04)
- National Heart, Lung, and Blood Institute (R01 HL 52745)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- body mass index, physical activity, C-reactive protein, inflammation, obesity, overweight, cardiovascular risk factors
- MeSH terms
- Adult, C-Reactive Protein, Female, Heart Diseases, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged, Obesity, Physical Fitness, Risk Factors, Biomarkers, Exercise, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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