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Cited by 86Muscle metabolism and nutritionCardiovascular and exercise physiologyNitric Oxide and Endothelin Effects

Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle

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Coggan, Andrew R., Peterson, Linda R.·2018·Exercise and Sport Sciences Reviews
DOI 10.1249/jes.0000000000000167PMC PMC6138552
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Abstract

Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca 2+ concentration along with the Ca 2+ sensitivity of the myofilaments themselves.

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  • Because muscle is unable to synthesize carnosine precursors, β-alanine supplementation induces an increase in intramuscular carnosine content, increasing buffering capacity.

    “As the muscle is unable to synthesize carnosine precursors, β-alanine supplementation induces an increase in intramuscular carnosine content increasing the buffering capacity [32].”

    From Dietary and Ergogenic Supplementation to Improve Elite Soccer Players’ Performance (2021) · cites this paper as [32]

    The Introduction and Mechanisms sections discuss dietary nitrate and nitric-oxide-related effects on muscle contraction, not β-alanine supplementation. Searches for β-alanine, carnosine precursors, intramuscular carnosine, and buffering capacity found no passage addressing the attributed claim. (LLM, conf=0.78)

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Cited by

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Authors
Coggan, A. R., & Peterson, L. R.
Affiliations
  • Indiana University – Purdue University Indianapolis (US)
  • Washington University in St. Louis (US)
Corresponding author
Coggan, Andrew R.
ORCID
Venue
Exercise and Sport Sciences Reviews
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-10
Volume
46
Issue
4
Pages
254-261
ISSN
  • 0091-6331 (ISSN-L)
  • 1538-3008
DOI
10.1249/jes.0000000000000167
PMC
PMC6138552
OpenAlex
W2883886248
Cited by
86
References
17
Citations by year
2026: 6 · 2025: 13 · 2024: 13 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 10
FWCI
1.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Exercise and Sport Sciences Reviews (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by-nc-nd)
  • Purdue University Indianapolis (Indiana University) (submittedVersion, cc-by-nc-nd)
  • PMC
Funders
  • National Institutes of Health (UL1TR002345)
  • National Heart, Lung, and Blood Institute (R34HL138253)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
dietary nitrate, nitric oxide, skeletal muscle contractility, soluble guanylate cyclase, cyclic GMP, protein kinase G, intracellular calcium, myofilament calcium sensitivity, exercise performance
MeSH terms
Animals, Calcium, Diet, Cyclic GMP, Humans, Muscle Contraction, Nitrates, Nitric Oxide, Signal Transduction, Cyclic GMP-Dependent Protein Kinases, Muscle, Skeletal, Ryanodine Receptor Calcium Release Channel

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