Cited by 288Mitochondrial Function and PathologyCardiovascular and exercise physiologyExercise and Physiological Responses

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Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

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PORTER, CRAIG, REIDY, PAUL T., BHATTARAI, NISHA, SIDOSSIS, LABROS S., RASMUSSEN, BLAKE B.·2015·Medicine & Science in Sports & Exercise

DOI 10.1249/mss.0000000000000605PMC PMC4478283

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Abstract

INTRODUCTION: Loss of mitochondrial competency is associated with several chronic illnesses. Therefore, strategies that maintain or increase mitochondrial function will likely be of benefit in numerous clinical settings. Endurance exercise has long been known to increase mitochondrial function in the skeletal muscle. Comparatively little is known regarding the effect of resistance exercise training (RET) on skeletal muscle mitochondrial respiratory function. PURPOSE: The purpose of the current study was to determine the effect of chronic resistance training on skeletal muscle mitochondrial respiratory capacity and function. METHODS: Here, we studied the effect of a 12-wk RET program on skeletal muscle mitochondrial function in 11 young healthy men. Muscle biopsies were collected before and after the 12-wk training program, and mitochondrial respiratory capacity was determined in permeabilized myofibers by high-resolution respirometry. RESULTS: RET increased lean body mass and quadriceps muscle strength by 4% and 15%, respectively (P < 0.001). Coupled mitochondrial respiration supported by complex I, and complex I and II substrates increased by 2- and 1.4-fold, respectively (P < 0.01). The ratio of coupled complex I-supported respiration to maximal respiration increased with RET (P < 0.05), as did complex I protein abundance (P < 0.05), whereas the substrate control ratio for succinate was reduced after RET (P < 0.001). Transcripts responsible for proteins critical to electron transfer and NAD production increased with training (P < 0.05), whereas transcripts involved in mitochondrial biogenesis were unaltered. CONCLUSIONS: Collectively, 12 wk of RET resulted in qualitative and quantitative changes in skeletal muscle mitochondrial respiration. This adaptation was accompanied by modest changes in mitochondrial proteins and transcript expression. RET seems to be a means to augment the respiratory capacity and intrinsic function of skeletal muscle mitochondria.

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Self-citation
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Authors: PORTER, C., REIDY, P. T., BHATTARAI, N., SIDOSSIS, L. S., & RASMUSSEN, B. B.
Affiliations: Shriners Hospitals for Children - Galveston (US)
The University of Texas Medical Branch at Galveston (US)
ORCID: PORTER, CRAIG
REIDY, PAUL T.
BHATTARAI, NISHA
SIDOSSIS, LABROS S.
RASMUSSEN, BLAKE B.
Venue: Medicine & Science in Sports & Exercise
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-09
Volume: 47
Issue: 9
Pages: 1922-1931
ISSN: 0195-9131 (ISSN-L)
DOI: 10.1249/mss.0000000000000605
PMC: PMC4478283
OpenAlex: W2018607292
Cited by: 288
References: 40
Citations by year: 2026: 26 · 2025: 41 · 2024: 36 · 2023: 37 · 2022: 28 · 2021: 28 · 2020: 25 · 2019: 22 · 2018: 23 · 2017: 9 · 2016: 6 · 2015: 7
FWCI: 3.00
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Medicine & Science in Sports & Exercise (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000071)
National Institute on Aging (P30AG024832)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049877)
NIH Clinical Center
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: resistance training, skeletal muscle mitochondria, mitochondrial respiration, complex I, succinic acid, mitochondrial biogenesis, electron transfer, muscle strength, lean body mass, exercise adaptation
MeSH terms: Adult, Humans, Male, Mitochondria, Muscle, Physical Education and Training, RNA, Messenger, Body Mass Index, Muscle, Skeletal, Cell Respiration, Electron Transport Chain Complex Proteins, Muscle Strength, Resistance Training, Young Adult

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Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

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