Autoregulation of Fox protein expression to produce dominant negative splicing factors
Open accessAbstract
The Fox proteins are a family of regulators that control the alternative splicing of many exons in neurons, muscle, and other tissues. Each of the three mammalian paralogs, Fox-1 ( A2BP1 ), Fox-2 ( RBM9 ), and Fox-3 ( HRNBP3 ), produces proteins with a single RNA-binding domain (RRM) flanked by N- and C-terminal domains that are highly diversified through the use of alternative promoters and alternative splicing patterns. These genes also express protein isoforms lacking the second half of the RRM (FoxΔRRM), due to the skipping of a highly conserved 93-nt exon. Fox binding elements overlap the splice sites of these exons in Fox-1 and Fox-2, and the Fox proteins themselves inhibit exon inclusion. Unlike other cases of splicing autoregulation by RNA-binding proteins, skipping the RRM exon creates an in-frame deletion in the mRNA to produce a stable protein. These FoxΔRRM isoforms expressed from cDNA exhibit highly reduced binding to RNA in vivo. However, we show that they can act as repressors of Fox-dependent splicing, presumably by competing with full-length Fox isoforms for interaction with other splicing factors. Interestingly, the Drosophila Fox homolog contains a nearly identical exon in its RRM domain that also has flanking Fox-binding sites. Thus, rather than autoregulation of splicing controlling the abundance of the regulator, the Fox proteins use a highly conserved mechanism of splicing autoregulation to control production of a dominant negative isoform.
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The mutually exclusive expression pattern of SLM1 and SLM2 is enforced by their cross-regulation via alternative splicing coupled with NMD.
“The mutually exclusive expression pattern of SLM1 and SLM2 is enforced by their cross-regulation via alternative splicing coupled with NMD, as seen with other paralogous pairs of RNA-binding proteins15,20,21,49,53,85,86.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [86]
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- Authors
- Damianov, A., & Black, D. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-12-30
- Volume
- 16
- Issue
- 2
- Pages
- 405-416
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- PMC
- PMC2811669
- OpenAlex
- W2158982822
- Cited by
- 120
- References
- 54
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 15 · 2016: 10 · 2015: 5 · 2014: 8 · 2013: 13 · 2012: 10
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- RNA (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (RO1 GM49662)
- National Institute of General Medical Sciences (R01GM049662)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- alternative splicing, RRM domain, exon skipping, RNA-binding proteins, splicing repressor, alternative promoters, protein isoforms
- MeSH terms
- RNA Splicing Factors, Amino Acid Sequence, Animals, Base Sequence, Cell Line, Female, Homeostasis, Humans, Male, Molecular Sequence Data, Gene Expression, RNA-Binding Proteins, Sequence Homology, Amino Acid, Alternative Splicing, DNA Primers, Mice
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