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Prenatal Phenol and Phthalate Exposures and Birth Outcomes
Open accessAbstract
BACKGROUND: Many phthalates and phenols are hormonally active and are suspected to alter the course of development. OBJECTIVE: We investigated prenatal exposures to phthalate and phenol metabolites and their associations with body size measures of the infants at birth. METHODS: We measured 5 phenol and 10 phthalate urinary metabolites in a multiethnic cohort of 404 women in New York City during their third trimester of pregnancy and recorded size of infants at birth. RESULTS: Median urinary concentrations were > 10 microg/L for 2 of 5 phenols and 6 of 10 phthalate monoester metabolites. Concentrations of low-molecular-weight phthalate monoesters (low-MWP) were approximately 5-fold greater than those of high-molecular-weight metabolites. Low-MWP metabolites had a positive association with gestational age [0.97 day gestational age per ln-biomarker; 95% confidence interval (CI), 0.07-1.9 days, multivariate adjusted] and with head circumference. Higher prenatal exposures to 2,5-dichlorophenol (2,5-DCP) predicted lower birth weight in boys (-210 g average birth weight difference between the third tertile and first tertile of 2,5-DCP; 95% CI, 71-348 g). Higher maternal benzophenone-3 (BP3) concentrations were associated with a similar decrease in birth weight among girls but with greater birth weight in boys. CONCLUSIONS: We observed a range of phthalate and phenol exposures during pregnancy in our population, but few were associated with birth size. The association of 2,5-DCP and BP3 with reduced or increased birth weight could be important in very early or small-size births. In addition, positive associations of urinary metabolites with some outcomes may be attributable partly to unresolved confounding with maternal anthropometric factors.
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Metadata
- Authors
- Wolff, M. S., Engel, S. M., Berkowitz, G. S., Ye, X., Silva, M. J., Zhu, C., Wetmur, J., & Calafat, A. M.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-08
- Volume
- 116
- Issue
- 8
- Pages
- 1092-1097
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2070823218
- Cited by
- 580
- References
- 0
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- gold
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