The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Prenatal Bisphenol A Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats
Open accessAbstract
BACKGROUND: Humans are routinely exposed to bisphenol A (BPA), an estrogenic compound that leaches from dental materials, food and beverage containers, and other consumer products. Prenatal exposure to BPA has produced long-lasting and profound effects on rodent hormone-dependent tissues that are manifested 1-6 months after the end of exposure. OBJECTIVE: The aim of the present work was to examine whether in utero exposure to BPA alters mammary gland development and increases its susceptibility to the carcinogen N-nitroso-N-methylurea (NMU). METHODS: Pregnant Wistar rats were exposed to BPA (25 pg/kg body weight per day) or to vehicle. Female offspring were sacrificed on postnatal day (PND) 30, 50, 110, or 180. On PND50 a group of rats received a single subcarcinogenic dose of NMU (25 mg/kg) and they were sacrificed on either PND110 or PND180. RESULTS: At puberty, animals exposed prenatally to BPA showed an increased proliferation/apoptosis ratio in both the epithelial and stromal compartments. During adulthood (PND110 and PND180), BPA-exposed animals showed an increased number of hyperplastic ducts and augmented stromal nuclear density. Moreover, the stroma associated with hyperplastic ducts showed signs of desmoplasia and contained an increased number of mast cells, suggesting a heightened risk of neoplastic transformation. Administration of a subcarcinogenic dose of NMU to animals exposed prenatally to BPA increased the percentage of hyperplastic ducts and induced the development of neoplastic lesions. CONCLUSIONS: Our results demonstrate that the prenatal exposure to low doses of BPA perturbs mammary gland histoarchitecture and increases the carcinogenic susceptibility to a chemical challenge administered 50 days after the end of BPA exposure.
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Cites
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Self-citationUrinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population
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Cited by
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Self-citationHormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
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Self-citationCancer is a preventable disease that requires major lifestyle changes
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Bisphenol A and human health: A review of the literature
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Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10753 · Cited by 1,743
Metadata
- Authors
- Durando, M., Kass, L., Piva, J., Sonnenschein, C., Soto, A. M., Luque, E. H., & Muñoz-de-Toro, M.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-01
- Volume
- 115
- Issue
- 1
- Pages
- 80-86
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2039711181
- Cited by
- 323
- References
- 44
- FWCI
- 12.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Durando, M., Kass, L., Piva, J., Sonnenschein, C., Soto, A. M., Luque, E. H., & Muñoz-de-Toro, M. (2007). Prenatal Bisphenol A Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats. Environmental Health Perspectives. https://doi.org/10.1289/ehp.9282
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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