Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men
Abstract
We investigated whether a low plasma testosterone level is related to endothelial dysfunction in men with coronary risk factors. One hundred and eighty-seven consecutive male outpatients (mean age+/-SD: 47+/-15 years) who underwent measurement of flow-mediated vasodilation (FMD) of the brachial artery using ultrasonography were enrolled. The relationship between plasma hormones and FMD was analyzed. Total and free testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were significantly correlated with %FMD (r=0.261, 0.354 and 0.295, respectively; p<0.001), while estradiol and cortisol were not. %FMD in the highest quartile of free testosterone was 1.7-fold higher than that in the lowest quartile. Multiple regression analysis revealed that total and free testosterone were related to %FMD independent of age, body mass index, hypertension, hyperlipidemia, diabetes mellitus and smoking (beta=0.198 and 0.247, respectively; p<0.01), and were independent of age, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, fasting plasma glucose, smoking and nitroglycerin-induced dilation (beta=0.196 and 0.227, respectively; p<0.01). DHEA-S was not significantly related to %FMD in multivariate analysis. In conclusion, a low plasma testosterone level was associated with endothelial dysfunction in men independent of other risk factors, suggesting a protective effect of endogenous testosterone on the endothelium.
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A prospective study has shown that TRT improves endothelial function.
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- Authors
- AKISHITA, M., HASHIMOTO, M., OHIKE, Y., OGAWA, S., IIJIMA, K., ETO, M., & OUCHI, Y.
- Affiliations
- The University of Tokyo (JP)
- Kobe University (JP)
- Corresponding author
- AKISHITA, Masahiro
- Venue
- Hypertension Research
- Publisher
- Japanese Society of Hypertension
- Published
- 2007
- Volume
- 30
- Issue
- 11
- Pages
- 1029-1034
- ISSN
- 0916-9636 (ISSN-L)
- 1348-4214
- OpenAlex
- W2105099107
- Cited by
- 179
- References
- 40
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 6 · 2019: 12 · 2018: 5 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 19 · 2012: 15
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- androgen deficiency, endothelial dysfunction, flow-mediated dilation, free testosterone, total testosterone, dehydroepiandrosterone sulfate, men, coronary risk factors, brachial artery, sex hormones, nitric oxide
- MeSH terms
- Adult, Aged, Endothelium, Vascular, Humans, Male, Middle Aged, Regression Analysis, Risk Factors, Testosterone, Vasodilation, Dehydroepiandrosterone Sulfate
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