Cited by 179Hormonal and reproductive studiesCardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men

AKISHITA, Masahiro, HASHIMOTO, Masayoshi, OHIKE, Yumiko, OGAWA, Sumito, IIJIMA, Katsuya, ETO, Masato, OUCHI, Yasuyoshi·2007·Hypertension Research

Abstract

We investigated whether a low plasma testosterone level is related to endothelial dysfunction in men with coronary risk factors. One hundred and eighty-seven consecutive male outpatients (mean age+/-SD: 47+/-15 years) who underwent measurement of flow-mediated vasodilation (FMD) of the brachial artery using ultrasonography were enrolled. The relationship between plasma hormones and FMD was analyzed. Total and free testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were significantly correlated with %FMD (r=0.261, 0.354 and 0.295, respectively; p<0.001), while estradiol and cortisol were not. %FMD in the highest quartile of free testosterone was 1.7-fold higher than that in the lowest quartile. Multiple regression analysis revealed that total and free testosterone were related to %FMD independent of age, body mass index, hypertension, hyperlipidemia, diabetes mellitus and smoking (beta=0.198 and 0.247, respectively; p<0.01), and were independent of age, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, fasting plasma glucose, smoking and nitroglycerin-induced dilation (beta=0.196 and 0.227, respectively; p<0.01). DHEA-S was not significantly related to %FMD in multivariate analysis. In conclusion, a low plasma testosterone level was associated with endothelial dysfunction in men independent of other risk factors, suggesting a protective effect of endogenous testosterone on the endothelium.

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Crossref · 10.1291/hypres.30.1029

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Authors
AKISHITA, M., HASHIMOTO, M., OHIKE, Y., OGAWA, S., IIJIMA, K., ETO, M., & OUCHI, Y.
Affiliations
  • The University of Tokyo (JP)
  • Kobe University (JP)
Corresponding author
AKISHITA, Masahiro
Venue
Hypertension Research
Published
2007
Volume
30
Issue
11
Pages
1029-1034
ISSN
  • 0916-9636 (ISSN-L)
  • 1348-4214
OpenAlex
W2105099107
Cited by
179
References
40
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 6 · 2019: 12 · 2018: 5 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 19 · 2012: 15
FWCI
7.09
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
androgen deficiency, endothelial dysfunction, flow-mediated dilation, free testosterone, total testosterone, dehydroepiandrosterone sulfate, men, coronary risk factors, brachial artery, sex hormones, nitric oxide
MeSH terms
Adult, Aged, Endothelium, Vascular, Humans, Male, Middle Aged, Regression Analysis, Risk Factors, Testosterone, Vasodilation, Dehydroepiandrosterone Sulfate

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