Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis
Open accessAbstract
BACKGROUND: Atopic dermatitis (AD) is a serious global epidemic associated with a modern lifestyle. OBJECTIVE: Although aberrant interactions between gut microbes and the intestinal immune system have been implicated in this skin disease, the nature of the microbiome dysfunction underlying the disease remains unclear. METHODS: The gut microbiome from 132 subjects, including 90 patients with AD, was analyzed by using 16S rRNA gene and metagenome sequence analyses. Reference genomes from the Human Microbiome Project and the KEGG Orthology database were used for metagenome analyses. Short-chain fatty acids in fecal samples were compared by using gas chromatographic-mass spectrometric analyses. RESULTS: We show that enrichment of a subspecies of the major gut species Faecalibacterium prausnitzii is strongly associated with AD. In addition, the AD microbiome was enriched in genes encoding the use of various nutrients that could be released from damaged gut epithelium, reflecting a bloom of auxotrophic bacteria. Fecal samples from patients with AD showed decreased levels of butyrate and propionate, which have anti-inflammatory effects. This is likely a consequence of an intraspecies compositional change in F prausnitzii that reduces the number of high butyrate and propionate producers, including those related to the strain A2-165, a lack of which has been implicated in patients with Crohn disease. CONCLUSIONS: The data suggest that feedback interactions between dysbiosis in F prausnitzii and dysregulation of gut epithelial inflammation might underlie the chronic progression of AD by resulting in impairment of the gut epithelial barrier, which ultimately leads to aberrant TH2-type immune responses to allergens in the skin.
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Gut dysbiosis has been observed in atopic dermatitis.
“Gut dysbiosis has been observed in conditions such as atopic dermatitis [82].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [82]
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Gut microbial composition in patients with psoriasis
Codoñer, F. M., Ramírez-Boscá, A., Climent, E., Carrión-Gutiérrez, M. A., Guerrero, M., Pérez-Orquín, J. M., de la Parte, J. H., Genovés, S., Ramón, D., Navarro‐López, V., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22125-y · Cited by 211 · see citing works
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Emerging trends and research foci in gastrointestinal microbiome
Huang, X., Fan, X., Ying, J., & Chen, S. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1810-x · Cited by 198 · see citing works
Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management?
Szántó, M., Dózsa, A., Antal, D., Szabó, K., Kemény, L., & Bai, P. (2019) · Experimental Dermatology · doi:10.1111/exd.14016 · Cited by 189 · see citing works
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“healthy control subjects (n=42) Korea; 2016 The proportion of Faecalibacterium prausnitzii was increased in patients with AD (49)”
BackgroundEtiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases
Schleimer, R. P., & Berdnikovs, S. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.010 · Cited by 188 · see citing works
“Moreover, the intestinal microbiome is now emerging as an important regulator of the metabolism with consequences for epithelial and immune homeostasis.(92)”
BackgroundB Vitamins and Their Roles in Gut Health
Hossain, K. S., Amarasena, S., & Mayengbam, S. (2022) · Microorganisms · doi:10.3390/microorganisms10061168 · Cited by 188 · see citing works
Reddel, S., CHIERICO, F. D., Quagliariello, A., Giancristoforo, S., Vernocchi, P., Russo, A., Fiocchi, A. G., Rossi, P., Putignani, L., & Hachem, M. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-41149-6 · Cited by 184 · see citing works
The exposome in atopic dermatitis
Stefanovic, N., Flohr, C., & Irvine, A. D. (2020) · Allergy · doi:10.1111/all.13946 · Cited by 181 · see citing works
Akkermansia muciniphila and Faecalibacterium prausnitzii in Immune-Related Diseases
Effendi, R. M. R. A., Anshory, M., Kalim, H., Dwiyana, R. F., Suwarsa, O., Pardo, L. M., Nijsten, T. E. C., & Thio, H. B. (2022) · Microorganisms · doi:10.3390/microorganisms10122382 · Cited by 190 · see citing works
Navarro‐López, V., Ramírez-Boscá, A., Ramón, D., Ruzafa-Costas, B., Genovés, S., Chenoll, E., Carrión-Gutiérrez, M. A., de la Parte, J. H., Prieto‐Merino, D., & Codoñer-Cortés, F. M. (2017) · JAMA Dermatology · doi:10.1001/jamadermatol.2017.3647 · Cited by 176 · see citing works
The role of short-chain fatty acids in inflammatory skin diseases
Xiao, X., Hu, X., Yao, J., Cao, W., Zou, Z., Wang, L., Qin, H., Zhong, D., Li, Y., Xue, P., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1083432 · Cited by 163 · see citing works
“Similar patterns have been observed in mixed age groups (Song et al., 2016) (see Table 1).”
ResultPrebiotics: Definition and protective mechanisms
Valcheva, R. S., & Dieleman, L. A. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.02.008 · Cited by 169 · see citing works
Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type
Lee, M.-J., Kang, M., Lee, S., Lee, E. M., Kim, K., Won, S., Suh, D. I., Kim, K. W., Sheen, Y. H., Ahn, K., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.11.045 · Cited by 158 · see citing works
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?
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“While the majority of microbiome studies focus on phyla and class level changes a recent investigation of the gut microbiome of patients with atopic dermatitis opens the possibility that sub-species level changes may have implications for the physiology of the host [93].”
Shu, S.-A., Yuen, A. W. T., Woo, E., Chu, K. H., Kwan, H. S., Yang, G., Yang, Y., & Leung, P. S. C. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8723-y · Cited by 160 · see citing works
Patients with Acne Vulgaris Have a Distinct Gut Microbiota in Comparison with Healthy Controls
Deng, Y., Wang, H., Zhou, J. W., Mou, Y., Wang, G., & Xiong, X. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-2968 · Cited by 158 · see citing works
Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women
Mörkl, S., Lackner, S., Meinitzer, A., Mangge, H., Lehofer, M., Halwachs, B., Gorkiewicz, G., Kashofer, K., Painold, A., Holl, A. K., et al. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1784-0 · Cited by 151 · see citing works
Demirci, M., Tokman, H. B., Uysal, H. K., Demiryas, S., Karakullukcu, A., Saribas, S., Cokugras, H., & Kocazeybek, B. S. (2019) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2018.12.009 · Cited by 150 · see citing works
Inoue, R., Sakaue, Y., Sawai, C., Sawai, T., Ozeki, M., Romero-Pérez, G. A., & Tsukahara, T. (2016) · Bioscience, Biotechnology, and Biochemistry · doi:10.1080/09168451.2016.1222267 · Cited by 148 · see citing works
The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review
Mesa, M. D., Loureiro, B., Iglesia, I., Gonzalez, S. F., Llurba, E., García‐Algar, Ó., Solana, M. J., Cabero-Pérez, M. J., Sainz, T., Martínez, L., et al. (2020) · Nutrients · doi:10.3390/nu12010133 · Cited by 146 · see citing works
“The presence of these bacteria is lower in Crohn’s disease patients, as well as anti-inflammatory fecal bacteria metabolites [138].”
BackgroundGut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy
Aitoro, R., Paparo, L., Amoroso, A., Costanzo, M. D., Cosenza, L., Granata, V., Scala, C. D., Nocerino, R., Trinchese, G., Montella, M. O., et al. (2017) · Nutrients · doi:10.3390/nu9070672 · Cited by 135 · see citing works
“As recently demonstrated, dysbiosis in Faecalibacterium prausnitzii is associated with AD, but it was shown that the presence of subspecies is more associated with AD than with the species overall [70].”
BackgroundHuang, W., Yin, H., Yang, Y., Jin, L., Lu, G., & Dang, Z. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146264 · Cited by 125 · see citing works
The gut microbiome in psoriasis and psoriatic arthritis
Myers, B., Brownstone, N., Reddy, V., Chan, S., Thibodeaux, Q., Truong, A., Bhutani, T., Chang, H.-W., & Liao, W. (2019) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2020.101494 · Cited by 127 · see citing works
Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.057 · Cited by 132 · see citing works
Probiotics for treating eczema
Makrgeorgou, A., Leonardi‐Bee, J., Bath-Hextall, F. J., Murrell, D. F., Tang, M. L. K., Roberts, A., & Boyle, R. J. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006135.pub3 · Cited by 130 · see citing works
Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients
Chen, Y.-J., Ho, H., Tseng, C., Lai, Z., Shieh, J., & Wu, C.-Y. (2018) · Experimental Dermatology · doi:10.1111/exd.13786 · Cited by 118 · see citing works
Kwon, M., Lim, S. K., Jang, J.-Y., Lee, J., Park, H. K., Kim, N., Yun, M., Shin, M.-Y., Jo, H. E., Oh, Y. J., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01905 · Cited by 121 · see citing works
“In human studies, infants with AD showed increased populations of Faecalibacterium prausnitzii subspecies (38) and Staphylococcus aureus (39).”
BackgroundThe gut microbiome alterations in allergic and inflammatory skin diseases – an update
Polkowska-Pruszyńska, B., Gerkowicz, A., & Krasowska, D. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15951 · Cited by 120 · see citing works
A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema
Ta, L. D. H., Chan, J. C. Y., Yap, G. C., Purbojati, R. W., Drautz‐Moses, D. I., Michelle, K. Y., Tay, C. J. X., Huang, C., Kioh, D. Y. Q., Woon, J. Y., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1801964 · Cited by 121 · see citing works
“producer – Faecalibacterium prausnitzii.(11) The Canadian CHILD birth cohort showed that lower stool acetate levels in infants was associated with childhood atopic wheeze.”
BackgroundGholizadeh, P., Mahallei, M., Pormohammad, A., Varshochi, M., Ganbarov, K., Zeinalzadeh, E., Yousefi, B., Bastami, M., Tanomand, A., Mahmood, S. S., et al. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.11.031 · Cited by 114 · see citing works
Boosting the Photoaged Skin: The Potential Role of Dietary Components
Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116 · see citing works
“Gut dysbiosis has been observed in conditions such as atopic dermatitis [82].”
BackgroundThe gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential
Jimenez-Sanchez, M., Celiberto, L. S., Yang, H., Sham, H. P., & Vallance, B. A. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2473524 · Cited by 131 · see citing works
“Created in BioRender.com. that butyrate can modulate immune responses in the skin, 103,104 and that it is also reduced in children and infants diagnosed with AD, 105,106 as well as in children that develop allergic reactions later in childhood.”
Human Microbiome: Composition and Role in Inflammatory Skin Diseases
Balato, A., Cacciapuoti, S., Caprio, R. D., Marasca, C., Masarà, A., Raimondo, A., & Fabbrocini, G. (2018) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-018-0528-4 · Cited by 110 · see citing works
Deep Metaproteomics Approach for the Study of Human Microbiomes
Zhang, X., Chen, W., Ning, Z., Mayne, J., Mack, D. R., Stintzi, A. P., Tian, R., & Figeys, D. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b02224 · Cited by 103 · see citing works
Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders
Alemao, C. A., Budden, K. F., Gomez, H. M., Rehman, S. F., Marshall, J. E., Shukla, S. D., Donovan, C., Forster, S. C., Yang, I. A., Keely, S., et al. (2020) · Allergy · doi:10.1111/all.14548 · Cited by 107 · see citing works
Mills, S., Yang, B. K., Smith, G., Stanton, C., & Ross, R. P. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2186098 · Cited by 106 · see citing works
Sjödin, K. S., Hammarström, M., Rydén, P., Sjödin, A., Hernell, O., Engstrand, L. G., & West, C. E. (2018) · Allergy · doi:10.1111/all.13485 · Cited by 105 · see citing works
“prausnitzii was reported in a metagenomic study including four patients with atopic eczema.(35) Analysis at the subspecies level was not the scope of this study, and the tolerogenic capacity of F.”
BackgroundHaifer, C., Kelly, C. R., Paramsothy, S., Andresen, D. N., Papanicolas, L. E., McKew, G. L., Borody, T. J., Kamm, M. A., Costello, S. P., Andrews, J. M., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320260 · Cited by 106 · see citing works
Jin, Q., Ren, F., Dai, D., Sun, N., Qian, Y., & Song, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1121273 · Cited by 103 · see citing works
“Several studies have discovered that the content of short-chain fatty acids (SCFAs) such as propionate and butyrate in patients with AD is significantly lower than that in healthy individuals (40, 41).”
BackgroundPark, Y. M., Lee, S., Kang, M., Kim, B. S., Lee, M.-J., Jung, S. S., Yoon, J., Cho, H., Lee, E. M., Yang, S., et al. (2020) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2020.12.2.322 · Cited by 100 · see citing works
Staphylococcus aureus and the Cutaneous Microbiota Biofilms in the Pathogenesis of Atopic Dermatitis
Domenico, E. G. D., Cavallo, I., Capitanio, B., Ascenzioni, F., Pimpinelli, F., Morrone, A., & Ensoli, F. (2019) · Microorganisms · doi:10.3390/microorganisms7090301 · Cited by 99 · see citing works
Dei‐Cas, I., Giliberto, F., Luce, L. N., Dopazo, H., & Steinhardt, A. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-69537-3 · Cited by 98 · see citing works
Role of the Gut Microbiota in Atopic Dermatitis: A Systematic Review
Pedersen, E., Skov, L., Thyssen, J. P., & Jensen, P. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-3008 · Cited by 97 · see citing works
Next generation probiotics for human health: An emerging perspective
Jan, T., Negi, R., Sharma, B., Kumar, S., Singh, S., Rai, A. K., Shreaz, S., Rustagi, S., Chaudhary, N., Kaur, T., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35980 · Cited by 95 · see citing works
Emerging evidence of the role of gut microbiota in the development of allergic diseases
Sjödin, K. S., Vidman, L., Rydén, P., & West, C. E. (2016) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000277 · Cited by 92 · see citing works
Moon, J., Lee, A. R., Kim, H., Jhun, J., Lee, S.-Y., Choi, J. W., Jeong, Y., Park, M. S., Ji, G. E., Cho, M., et al. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03118-3 · Cited by 94 · see citing works
“Faecalibacterium prausnitzii (formerly known as Fusobacterium prausnitzii) is an anaerobic gram-positive, non-spore-forming, acetate-consuming, butyrateproducing, and extremely oxygen-sensitive bacterium [20, 21].”
Systematic review of the association between short‐chain fatty acids and allergic diseases
Sasaki, M., Suaini, N. H. A., Afghani, J., Heye, K., O’Mahony, L., Venter, C., Lauener, R. P., Frei, R., & Roduit, C. (2024) · Allergy · doi:10.1111/all.16065 · Cited by 89 · see citing works
New Insights into the Diversity of the Genus Faecalibacterium
Benevides, L., Burman, S., Martin, R., Robert, V., Thomas, M., Miquel, S., Chain, F., Sokol, H., Bermudez-Humaran, L. G., Morrison, M., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01790 · Cited by 86 · see citing works
“…samples of AD patients were enriched in those similar to strain L2-6 with respect to other strains of F. prausnitzii; they also proposed that strain L2-6 can be differentiated from other strains by the existence of a polycistronic region encoding GalNac uptake and metabolism (Song et al., 2016).”
BackgroundThe Prospects for the Therapeutic Implications of Genetically Engineered Probiotics
Mazhar, S. F., Afzal, M., Almatroudi, A., Munir, S., Ashfaq, U. A., Rasool, M., Raza, H., Munir, H. M. W., Rajoka, M. S. R., & Khurshid, M. (2020) · Journal of Food Quality · doi:10.1155/2020/9676452 · Cited by 85 · see citing works
Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases
Stec, A., Sikora, M., Maciejewska, M., Paralusz-Stec, K., Michalska, M. N., Sikorska, E., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043494 · Cited by 85 · see citing works
“Moreover, the microbiota in AD produce fewer SCFAs, particularly propionate and butyrate, which have been assessed in fecal samples [38,39].”
BackgroundDo an Altered Gut Microbiota and an Associated Leaky Gut Affect COVID-19 Severity?
Kim, H. S. (2021) · mBio · doi:10.1128/mbio.03022-20 · Cited by 82 · see citing works
“understand its influence on human health and disease (57, 58).”
BackgroundFecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study
Fieten, K. B., Totté, J. E. E., Levin, E., Reyman, M., Meijer, Y., Knulst, A. C., Schuren, F. H. J., & Pasmans, S. G. M. A. (2018) · International Archives of Allergy and Immunology · doi:10.1159/000484897 · Cited by 85 · see citing works
Evolving trends in next-generation probiotics: a 5W1H perspective
Almeida, D., Machado, D., Andrade, J. C., Mendo, S., Gomes, A. M., & Freitas, A. C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1599812 · Cited by 92 · see citing works
“prausnitzii F6 (a low butyrate producer strain) in atopic dermatitis Case control studies (Song et al. 2016; Zheng et al. 2016; Candela et al. 2012)”
BackgroundRosacea and its association with enteral microbiota in Korean females
Nam, J., Yun, Y., Kim, H., Kim, H., Jung, H. J., Chang, Y., Ryu, S., Shin, H., Kim, H., & Kim, W. (2017) · Experimental Dermatology · doi:10.1111/exd.13398 · Cited by 82 · see citing works
Dokoshi, T., Chen, Y., Cavagnero, K. J., Rahman, G., Hakim, D., Brinton, S. L., Schwarz, H., Brown, E. A. R., O’Neill, A., Nakamura, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47072-3 · Cited by 83 · see citing works
“Although prior studies have observed dysbiosis in the gut microbiome of individuals with in fl am-matoryskindisease,ithadbeenassumedthatmicrobesinthegutwere in fl uencing the skin 28 – 30 .”
Microbiome in atopic dermatitis
Wollina, U. (2017) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s130013 · Cited by 85 · see citing works
“41 Another study used microarray analysis of intestinal microbiome in infants with and without AD at 6 and 18 months of age.”
Puig‐Castellví, F., Pacheco‐Tapia, R., Deslande, M., Jia, M., Andrikopoulos, P., Chechi, K., Bonnefond, A., Froguel, P., & Dumas, M. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117248 · Cited by 84 · see citing works
Mottin, V. H. M., & Suyenaga, E. S. (2018) · International Journal of Dermatology · doi:10.1111/ijd.13972 · Cited by 83 · see citing works
Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis
Park, D. H., Kim, J. W., Park, H., & Hahm, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084228 · Cited by 76 · see citing works
“According to a recent study in Korea, significant dysbiosis (specifically an intraspecies compositional change) of a subspecies of Faecalibacterium prausnitzii was found in the fecal samples of patients with AD [9].”
BackgroundAge and fecal microbial strain-specific differences in patients with spondyloarthritis
Stoll, M. L., Weiss, P. F., Weiss, J. E., Nigrovic, P. A., Edelheit, B. S., Bridges, S., Danila, M. I., Spencer, C. H., Punaro, M., Schikler, K. N., et al. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1510-6 · Cited by 75 · see citing works
“prausnitzii, such as L2/6, the A2-165 strain induces increased interleukin-10 production from peripheral blood mononuclear cells [16, 40] and has increased butyrate promoter activity [41].”
BackgroundRecent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity
Gianchecchi, E., & Fierabracci, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020283 · Cited by 74 · see citing works
“[93] observed a significant correlation between the high abundance of F.”
BackgroundInfluentialMicrobial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes
Augustine, T., Kumar, M., Khodor, S. A., & van Panhuys, N. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-022-08939-9 · Cited by 75 · see citing works
“As the intestinal barrier function can be impaired in those patients [58], with impairment often being associ‐ ated with an enrichment of Fecalibacterium, in particular, Fecalibacterum prausnitzii, a non‐short chain fatty acid (SFCA)‐producing bacteria which is especially common in pediatric atopic dermatitis [59] and…”
BackgroundProbiotics: Protecting Our Health from the Gut
Varela-Trinidad, G. U., Domínguez-Díaz, C., Solórzano-Castanedo, K., Íñiguez-Gutiérrez, L., Hernández-Flores, T. D. J., & Fafutis‐Morris, M. (2022) · Microorganisms · doi:10.3390/microorganisms10071428 · Cited by 78 · see citing works
“In addition, AD patients have low levels of SCFAs, such as butyrate and propionate, due to a reduction in the number of bacteria producing these metabolites, which is associated with AD severity [141,142].”
BackgroundAtopic dermatitis: Pathophysiology, microbiota, and metabolome – A comprehensive review
Mohammad, S., Karim, M. R., Iqbal, S., Lee, J. H., Mathiyalagan, R., Kim, Y. J., Yang, D. U., & Yang, D. (2024) · Microbiological Research · doi:10.1016/j.micres.2023.127595 · Cited by 78 · see citing works
van Dijkhuizen, E. H. P., CHIERICO, F. D., Malattia, C., Russo, A., Marafon, D. P., ter Haar, N. M., Magni‐Manzoni, S., Vastert, S. J., Dallapiccola, B., Prakken, B. J., et al. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40827 · Cited by 74 · see citing works
Kim, H., Lee, S., & Hong, S. (2019) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2020.12.1.137 · Cited by 72 · see citing works
The Role of Diet and Nutrition in Allergic Diseases
Zhang, P. (2023) · Nutrients · doi:10.3390/nu15173683 · Cited by 76 · see citing works
“Consistent with animal studies, dysbiosis characterized by the enrichment of Faecalibacterium prausnitzii and a reduced capacity for butyrate fermentation in the human gut microbiome has been found in patients with AD [84].”
ResultSlattery, J. M., MacFabe, D. F., & Frye, R. E. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38338 · Cited by 72 · see citing works
McIntyre, M. K., Peacock, T. J., Akers, K. S., & Burmeister, D. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166176 · Cited by 71 · see citing works
Carucci, L., Nocerino, R., Paparo, L., Filippis, F. D., Coppola, S., Giglio, V., Cozzolino, T., Valentino, V., Sequino, G., Bedogni, G., et al. (2022) · Pediatric Allergy and Immunology · doi:10.1111/pai.13836 · Cited by 79 · see citing works
Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies
Alam, J., Xie, L., Yap, Y. A., Marques, F. Z., & Robert, R. (2022) · Pathogens · doi:10.3390/pathogens11060642 · Cited by 69 · see citing works
- Authors
- Song, H., Yoo, Y., Hwang, J., Na, Y.-C., & Kim, H. S.
- Affiliations
- Korea University (KR)
- Korea Basic Science Institute (KR)
- Corresponding author
- Kim, Heenam Stanley
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 137
- Issue
- 3
- Pages
- 852-860
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1822404940
- Cited by
- 416
- References
- 61
- Citations by year
- 2026: 27 · 2025: 40 · 2024: 64 · 2023: 57 · 2022: 43 · 2021: 55 · 2020: 28 · 2019: 28 · 2018: 39 · 2017: 18 · 2016: 16 · 2015: 1
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- atopic dermatitis, Faecalibacterium prausnitzii, gut dysbiosis, short-chain fatty acids, butyrate, propionate, intestinal epithelial barrier, Th2 immune response, Crohn's disease, intestinal immune regulation
- MeSH terms
- Eubacteriales, Gastrointestinal Microbiome, Dermatitis, Atopic, Feces, Female, Humans, Male, Models, Biological, Phylogeny, RNA, Ribosomal, 16S, Cluster Analysis, Sequence Analysis, DNA, Computational Biology, Metagenome, Metagenomics, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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