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Side Effects of Minocycline Treatment in Patients With Fragile X Syndrome and Exploration of Outcome Measures
Open accessAbstract
Minocycline can rescue the dendritic spine and synaptic structural abnormalities in the fragile X knock-out mouse. This is a review and preliminary survey to document side effects and potential outcome measures for minocycline use in the treatment of individuals with fragile X syndrome. We surveyed 50 patients with fragile X syndrome who received minocycline for at least 2 weeks and found that the most common reported side effect is gastrointestinal difficulty, including loss of appetite. The families reported an improvement in language and behavioral areas. Outcome measures in the design of future randomized clinical trials should include both behavioral and language measures. As with any other treatments, we emphasize that randomized clinical trials are needed to determine the efficacy of minocycline in fragile X syndrome.
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“This work stimulated a survey study of families whose children were treated with minocycline, and 70% noted an improvement in behavior or language (126).”
From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [126]
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InfluentialPseudotumor cerebri secondary to minocycline intake.
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Sorted by citations
Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
Hagerman, R. J., Berry-Kravis, E., Hazlett, H. C., Bailey, D. B., Moine, H., Kooy, R. F., Tassone, F., Gantois, I., Sonenberg, N., Mandel, J. L., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.65 · Cited by 838
Self-citationFragile X syndrome: causes, diagnosis, mechanisms, and therapeutics
Bagni, C., Tassone, F., Neri, G., & Hagerman, R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63141 · Cited by 321
Self-citationLeigh, M. J. S., Nguyen, D. V., Mu, Y., Winarni, T. I., Schneider, A., Chechi, T., Polussa, J., Doucet, P., Tassone, F., Rivera, S. M., et al. (2013) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e318287cd17 · Cited by 298
Self-citationDisruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions
Nussbacher, J. K., Tabet, R., Yeo, G. W.-M., & Lagier‐Tourenne, C. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.014 · Cited by 271
Metadata
- Authors
- Utari, A., Chonchaiya, W., Rivera, S. M., Schneider, A., Hagerman, R. J., Faradz, S. M. H., Ethell, I. M., & Nguyen, D. V.
- Affiliations
- University of California Davis Medical Center (US)
- Diponegoro University (ID)
- University of California, Riverside (US)
- University of California, Davis (US)
- ORCID
- Venue
- American Journal on Intellectual and Developmental Disabilities
- Publisher
- Informa UK Limited
- Published
- 2010-09-01
- Volume
- 115
- Issue
- 5
- Pages
- 433-443
- ISSN
- 1944-7558 (ISSN-L)
- 1944-7515
- PMC
- PMC4031088
- OpenAlex
- W2134986933
- Cited by
- 105
- References
- 71
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 9 · 2018: 2 · 2017: 8 · 2016: 3 · 2015: 5 · 2014: 11 · 2013: 17 · 2012: 14
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- American Journal on Intellectual and Developmental Disabilities (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Centers for Disease Control and Prevention (90DD05969)
- National Center for Research Resources (UL1RR024146)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD036071, HD 02274, P30HD002274, R01HD036071)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- minocycline, fragile X syndrome, adverse drug reactions, gastrointestinal adverse effects, appetite loss, language outcomes, behavioral effects, outcome measures, randomized controlled trials, tetracycline antibiotics, synaptic abnormalities
- MeSH terms
- Adolescent, Anti-Bacterial Agents, Child, Child Behavior Disorders, Child, Preschool, Female, Follow-Up Studies, Fragile X Syndrome, Humans, Infant, Language Development Disorders, Male, Minocycline, Randomized Controlled Trials as Topic, Neuroprotective Agents, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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