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Cited by 357

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly

Open access
Jouvenet, Nolwenn, Neil, Stuart J. D, Bess, Cameron, Johnson, Marc C, Virgen, Cesar A, Simon, Sanford M, Bieniasz, Paul D·2006·PLoS Biology
DOI 10.1371/journal.pbio.0040435
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Abstract

Recently proposed models that have gained wide acceptance posit that HIV-1 virion morphogenesis is initiated by targeting the major structural protein (Gag) to late endosomal membranes. Thereafter, late endosome-based secretory pathways are thought to deliver Gag or assembled virions to the plasma membrane (PM) and extracellular milieu. We present several findings that are inconsistent with this model. Specifically, we demonstrate that HIV-1 Gag is delivered to the PM, and virions are efficiently released into the extracellular medium, when late endosome motility is abolished. Furthermore, we show that HIV-1 virions are efficiently released when assembly is rationally targeted to the PM, but not when targeted to late endosomes. Recently synthesized Gag first accumulates and assembles at the PM, but a proportion is subsequently internalized via endocytosis or phagocytosis, thus accounting for observations of endosomal localization. We conclude that HIV-1 assembly is initiated and completed at the PM, and not at endosomal membranes.

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Crossref · 10.1371/journal.pbio.0040435

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Metadata

Authors
Jouvenet, N., Neil, S. J. D., Bess, C., Johnson, M. C., Virgen, C. A., Simon, S. M., & Bieniasz, P. D.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2006-12-05
Volume
4
Issue
12
Pages
e435
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.0040435
OpenAlex
W2124493183
Cited by
357
References
70
FWCI
10.46
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

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