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Cited by 579

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Sparse Representation of Sounds in the Unanesthetized Auditory Cortex

Open access
Hromádka, Tomáš, DeWeese, Michael R, Zador, Anthony M·2008·PLoS Biology
DOI 10.1371/journal.pbio.0060016
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Abstract

How do neuronal populations in the auditory cortex represent acoustic stimuli? Although sound-evoked neural responses in the anesthetized auditory cortex are mainly transient, recent experiments in the unanesthetized preparation have emphasized subpopulations with other response properties. To quantify the relative contributions of these different subpopulations in the awake preparation, we have estimated the representation of sounds across the neuronal population using a representative ensemble of stimuli. We used cell-attached recording with a glass electrode, a method for which single-unit isolation does not depend on neuronal activity, to quantify the fraction of neurons engaged by acoustic stimuli (tones, frequency modulated sweeps, white-noise bursts, and natural stimuli) in the primary auditory cortex of awake head-fixed rats. We find that the population response is sparse, with stimuli typically eliciting high firing rates (>20 spikes/second) in less than 5% of neurons at any instant. Some neurons had very low spontaneous firing rates (<0.01 spikes/second). At the other extreme, some neurons had driven rates in excess of 50 spikes/second. Interestingly, the overall population response was well described by a lognormal distribution, rather than the exponential distribution that is often reported. Our results represent, to our knowledge, the first quantitative evidence for sparse representations of sounds in the unanesthetized auditory cortex. Our results are compatible with a model in which most neurons are silent much of the time, and in which representations are composed of small dynamic subsets of highly active neurons.

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Metadata

Authors
Hromádka, T., DeWeese, M. R., & Zador, A. M.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2008-01-29
Volume
6
Issue
1
Pages
e16
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.0060016
OpenAlex
W1977450749
Cited by
579
References
70
FWCI
14.93
Type
journal article
Language
en
Open access
gold

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