CoChat
Sign Up
Cited by 69HIV Research and TreatmentHIV/AIDS Research and InterventionsT-cell and Retrovirus Studies

HIV-1 cell-to-cell transmission and broadly neutralizing antibodies

Open access
Dufloo, Jérémy, Bruel, Timothée, Schwartz, Olivier·2018·Retrovirology
DOI 10.1186/s12977-018-0434-1PMC PMC6064125
Open this paper in CoChat — free accountOpen PDF

Abstract

HIV-1 spreads through contacts between infected and target cells. Polarized viral budding at the contact site forms the virological synapse. Additional cellular processes, such as nanotubes, filopodia, virus accumulation in endocytic or phagocytic compartments promote efficient viral propagation. Cell-to-cell transmission allows immune evasion and likely contributes to HIV-1 spread in vivo. Anti-HIV-1 broadly neutralizing antibodies (bNAbs) defeat the majority of circulating viral strains by binding to the viral envelope glycoprotein (Env). Several bNAbs have entered clinical evaluation during the last years. It is thus important to understand their mechanism of action and to determine how they interact with infected cells. In experimental models, HIV-1 cell-to-cell transmission is sensitive to neutralization, but the effect of antibodies is often less marked than during cell-free infection. This may be due to differences in the conformation or accessibility of Env at the surface of virions and cells. In this review, we summarize the current knowledge on HIV-1 cell-to-cell transmission and discuss the role of bNAbs during this process.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s12977-018-0434-1

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Cell contact-mediated infection is resistant to neutralizing antibodies, demonstrated for HIV-1 and SARS-CoV-2.

    “The importance of the cell-to-cell transmission mechanism for viral dissemination is evidenced by the resistance of cell contact-mediated infection to neutralizing antibodies, which has been demonstrated for HIV-1 [140] and SARS-CoV-2 [33,141].”

    From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [140]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 147

  1. [1]Barre-Sinoussi F Chermann J Rey F Nugeyre M Chamaret S Gruest J Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) Science 1983 220 868 871 10.1126/science.6189183 6189183 · DOI · Paper page
  2. [2]Schiffner T Sattentau QJ Duncan CJA Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies Vaccine. 2013 31 5789 5797 10.1016/j.vaccine.2013.10.020 24140477 · DOI
  3. [3]Casartelli N HIV-1 cell-to-cell transmission and antiviral strategies: an overview Curr Drug Targets 2016 17 65 75 10.2174/138945011701151217105638 26687604 · DOI
  4. [4]Bracq L Xie M Benichou S Bouchet J Mechanisms for cell-to-cell transmission of HIV-1 Front Immunol 2018 9 260 10.3389/fimmu.2018.00260 29515578 PMC5825902 · DOI
  5. [5]Jolly C Kashefi K Hollinshead M Sattentau QJ HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse J Exp Med 2004 199 283 293 10.1084/jem.20030648 14734528 PMC2211771 · DOI · Paper page
  6. [6]Monel B Beaumont E Vendrame D Schwartz O Brand D Mammano F HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through Env-mediated fusion pores J Virol 2012 86 3924 3933 10.1128/JVI.06478-11 22258237 PMC3302491 · DOI
  7. [7]Tomaras GD Yates NL Liu P Qin L Fouda GG Chavez LL Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia J Virol 2008 82 12449 12463 10.1128/JVI.01708-08 18842730 PMC2593361 · DOI
  8. [8]Frost SDW Wrin T Smith DM Pond SLK Liu Y Paxinos E Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection Proc Natl Acad Sci 2005 102 18514 18519 10.1073/pnas.0504658102 16339909 PMC1310509 · DOI
  9. [9]Wei X Decker JM Wang S Hui H Kappes JC Wu X Antibody neutralization and escape by HIV-1 Nature 2003 422 307 312 10.1038/nature01470 12646921 · DOI · Paper page
  10. [10]Deeks SG Schweighardt B Wrin T Galovich J Hoh R Sinclair E Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses J Virol 2006 80 6155 6164 10.1128/JVI.00093-06 16731954 PMC1472617 · DOI
  11. [11]Simek MD Rida W Priddy FH Pung P Carrow E Laufer DS Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm J Virol 2009 83 7337 7348 10.1128/JVI.00110-09 19439467 PMC2704778 · DOI
  12. [12]McCoy LE Burton DR Identification and specificity of broadly neutralizing antibodies against HIV Immunol Rev 2017 275 11 20 10.1111/imr.12484 28133814 PMC5299474 · DOI
  13. [13]Mouquet H Antibody B cell responses in HIV-1 infection Trends Immunol 2014 35 549 561 10.1016/j.it.2014.08.007 25240985 · DOI
  14. [14]Kong R Xu K Zhou T Acharya P Lemmin T Liu K Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody Science 2016 352 828 833 10.1126/science.aae0474 27174988 PMC4917739 · DOI
  15. [15]van Gils MJ van den Kerkhof TLGM Ozorowski G Cottrell CA Sok D Pauthner M An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability Nat Microbiol 2016 2 16199 10.1038/nmicrobiol.2016.199 27841852 PMC5372380 · DOI
  16. [16]Xu K Acharya P Kong R Cheng C Chuang G-Y Liu K Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 Nat Med 2018 24 857 867 10.1038/s41591-018-0042-6 29867235 PMC6358635 · DOI
  17. [17]Bruel T Guivel-Benhassine F Amraoui S Malbec M Richard L Bourdic K Elimination of HIV-1-infected cells by broadly neutralizing antibodies Nat Commun 2016 7 10844 10.1038/ncomms10844 26936020 PMC4782064 · DOI
  18. [18]Shingai M Donau OK Plishka RJ Buckler-White A Mascola JR Nabel GJ Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques J Exp Med 2014 211 2061 2074 10.1084/jem.20132494 25155019 PMC4172223 · DOI
  19. [19]Nishimura Y Martin MA Of mice, macaques, and men: broadly neutralizing antibody immunotherapy for HIV-1 Cell Host Microbe 2017 22 207 216 10.1016/j.chom.2017.07.010 28799906 PMC5572834 · DOI
  20. [20]Lu C-L Murakowski DK Bournazos S Schoofs T Sarkar D Halper-Stromberg A Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo Science 2016 352 1001 1004 10.1126/science.aaf1279 27199430 PMC5126967 · DOI
  21. [21]Nishimura Y Gautam R Chun T-W Sadjadpour R Foulds KE Shingai M Early antibody therapy can induce long-lasting immunity to SHIV Nature 2017 543 559 563 10.1038/nature21435 28289286 PMC5458531 · DOI
  22. [22]Cohen YZ Caskey M Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection Curr Opin HIV AIDS 2018 13 366 737 10.1097/COH.0000000000000475 29697469 · DOI
  23. [23]Caskey M Klein F Lorenzi JCC Seaman MS West AP Buckley N Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 Nature 2015 522 487 491 10.1038/nature14411 25855300 PMC4890714 · DOI
  24. [24]Lynch RM Boritz E Coates EE DeZure A Madden P Costner P Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection Sci Transl Med. 2015 2015 319ra206 319ra206 10.1126/scitranslmed.aad5752 PMC12366723 26702094 · DOI
  25. [25]Caskey M Schoofs T Gruell H Settler A Karagounis T Kreider EF Antibody 10-1074 suppresses viremia in HIV-1-infected individuals Nat Med 2017 23 185 191 10.1038/nm.4268 28092665 PMC5467219 · DOI
  26. [26]Scheid JF Horwitz JA Bar-On Y Kreider EF Lu C-L Lorenzi JCC HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption Nature 2016 535 556 560 10.1038/nature18929 27338952 PMC5034582 · DOI
  27. [27]Schoofs T Klein F Braunschweig M Kreider EF Feldmann A Nogueira L HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1 Science 2016 352 997 1001 10.1126/science.aaf0972 27199429 PMC5151174 · DOI
  28. [28]Pearce-Pratt R Phillips DM Studies of adhesion of lymphocytic cells: implications for sexual transmission of human immunodeficiency virus1 Biol Reprod 1993 48 431 445 10.1095/biolreprod48.3.431 8452921 · DOI
  29. [29]Pearce-Pratt R Malamud D Phillips DM Role of the cytoskeleton in cell-to-cell transmission of human immunodeficiency virus J Virol 1994 68 2898 2905 8151760 PMC236778
  30. [30]Fais S Capobianchi MR Abbate I Castilletti C Gentile M Cordiali Fei P Unidirectional budding of HIV-1 at the site of cell-to-cell contact is associated with co-polarization of intercellular adhesion molecules and HIV-1 viral matrix protein AIDS. 1995 9 329 335 10.1097/00002030-199509040-00003 7794538 · DOI
  31. [31]Igakura T Stinchcombe JC Goon PKC Taylor GP Weber JN Griffiths GM Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton Science 2003 299 1713 1716 10.1126/science.1080115 12589003 · DOI · Paper page
  32. [32]Vasiliver-Shamis G Dustin ML Hioe CE HIV-1 virological synapse is not simply a copycat of the immunological synapse Viruses. 2010 2 1239 1260 10.3390/v2051239 20890395 PMC2947835 · DOI
  33. [34]Roy NH Chan J Lambele M Thali M Clustering and mobility of HIV-1 Env at viral assembly sites predict its propensity to induce cell-cell fusion J Virol 2013 87 7516 7525 10.1128/JVI.00790-13 23637402 PMC3700267 · DOI · Paper page
  34. [35]Weng J Krementsov DN Khurana S Roy NH Thali M Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells J Virol 2009 83 7467 7474 10.1128/JVI.00163-09 19458002 PMC2708618 · DOI · Paper page
  35. [36]Roy NH Lambele M Chan J Symeonides M Thali M Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion J Virol 2014 88 7645 7658 10.1128/JVI.00550-14 24760896 PMC4054451 · DOI · Paper page
  36. [37]Blanco J Bosch B Fernández-Figueras MT Barretina J Clotet B Esté JA High level of coreceptor-independent HIV transfer induced by contacts between primary CD4 T cells J Biol Chem 2004 279 51305 51314 10.1074/jbc.M408547200 15371410 · DOI · Paper page
  37. [38]Hubner W McNerney GP Chen P Dale BM Gordon RE Chuang FYS Quantitative 3D video microscopy of HIV transfer across T cell virological synapses Science 2009 323 1743 1747 10.1126/science.1167525 19325119 PMC2756521 · DOI · Paper page
  38. [39]Jolly C Mitar I Sattentau QJ Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells J Virol 2007 81 13916 13921 10.1128/JVI.01585-07 17913807 PMC2168851 · DOI · Paper page
  39. [40]Puigdomenech I Massanella M Izquierdo-Useros N Ruiz-Hernandez R Curriu M Bofill M HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4 Retrovirology. 2008 5 32 10.1186/1742-4690-5-32 18377648 PMC2359761 · DOI
  40. [42]Haller C Tibroni N Rudolph JM Grosse R Fackler OT Nef does not inhibit F-actin remodelling and HIV-1 cell–cell transmission at the T lymphocyte virological synapse Eur J Cell Biol 2011 90 913 921 10.1016/j.ejcb.2010.09.010 21044805 · DOI
  41. [43]Sol-Foulon N Sourisseau M Porrot F Thoulouze M-I Trouillet C Nobile C ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation EMBO J 2007 26 516 526 10.1038/sj.emboj.7601509 17215865 PMC1783460 · DOI
  42. [44]Jolly C Welsch S Michor S Sattentau QJ The regulated secretory pathway in CD4 + T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse PLoS Pathog 2011 7 e1002226 10.1371/journal.ppat.1002226 21909273 PMC3164651 · DOI
  43. [45]Jolly C Sattentau QJ Human immunodeficiency virus type 1 virological synapse formation in T cells requires lipid raft integrity J Virol 2005 79 12088 12094 10.1128/JVI.79.18.12088-12094.2005 16140785 PMC1212596 · DOI
  44. [46]Malbec M Sourisseau M Guivel-Benhassine F Porrot F Blanchet F Schwartz O HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer Retrovirology. 2013 10 80 10.1186/1742-4690-10-80 23899341 PMC3734038 · DOI
  45. [47]Casartelli N Sourisseau M Feldmann J Guivel-Benhassine F Mallet A Marcelin A-G Tetherin restricts productive HIV-1 cell-to-cell transmission PLoS Pathog 2010 6 e1000955 10.1371/journal.ppat.1000955 20585562 PMC2887479 · DOI
  46. [48]Kuhl BD Sloan RD Donahue DA Bar-Magen T Liang C Wainberg MA Tetherin restricts direct cell-to-cell infection of HIV-1 Retrovirology. 2010 7 115 10.1186/1742-4690-7-115 21184674 PMC3017029 · DOI
  47. [49]Jolly C Booth NJ Neil SJD Cell-cell spread of human immunodeficiency virus type 1 overcomes tetherin/BST-2-mediated restriction in T cells J Virol 2010 84 12185 12199 10.1128/JVI.01447-10 20861257 PMC2976402 · DOI
  48. [51]Tartour K Appourchaux R Gaillard J Nguyen X-N Durand S Turpin J IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity Retrovirology 2014 11 103 10.1186/s12977-014-0103-y 25422070 PMC4251951 · DOI
  49. [52]Bosch B Grigorov B Senserrich J Clotet B Darlix J Muriaux D A clathrin–dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell–T cell transmission Antiviral Res 2008 80 185 193 10.1016/j.antiviral.2008.06.004 18602423 · DOI
  50. [53]Sloan RD Kuhl BD Mesplede T Munch J Donahue DA Wainberg MA Productive entry of HIV-1 during cell-to-cell transmission via dynamin-dependent endocytosis J Virol 2013 87 8110 8123 10.1128/JVI.00815-13 23678185 PMC3700189 · DOI
  51. [54]Dale BM McNerney GP Thompson DL Hubner W de los Reyes K Chuang FYS Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion Cell Host Microbe 2011 10 551 562 10.1016/j.chom.2011.10.015 22177560 PMC3278276 · DOI · Paper page
  52. [55]Herold N Anders-Osswein M Glass B Eckhardt M Muller B Krausslich H-G HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4 + T cells occurs at the plasma membrane and does not require endocytosis J Virol 2014 88 13956 13970 10.1128/JVI.01543-14 25253335 PMC4249123 · DOI
  53. [56]Sourisseau M Sol-Foulon N Porrot F Blanchet F Schwartz O Inefficient human immunodeficiency virus replication in mobile lymphocytes J Virol 2007 81 1000 1012 10.1128/JVI.01629-06 17079292 PMC1797449 · DOI · Paper page
  54. [57]Chen P Hubner W Spinelli MA Chen BK Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses J Virol 2007 81 12582 12595 10.1128/JVI.00381-07 17728240 PMC2169007 · DOI · Paper page
  55. [58]Del Portillo A Tripodi J Najfeld V Wodarz D Levy DN Chen BK Multiploid inheritance of HIV-1 during cell-to-cell infection J Virol 2011 85 7169 7176 10.1128/JVI.00231-11 21543479 PMC3126592 · DOI
  56. [59]Russell RA Martin N Mitar I Jones E Sattentau QJ Multiple proviral integration events after virological synapse-mediated HIV-1 spread Virology 2013 443 143 149 10.1016/j.virol.2013.05.005 23722103 · DOI
  57. [60]Boullé M Müller TG Dähling S Ganga Y Jackson L Mahamed D HIV cell-to-cell spread results in earlier onset of viral gene expression by multiple infections per cell PLoS Pathog 2016 12 e1005964 10.1371/journal.ppat.1005964 27812216 PMC5094736 · DOI
  58. [61]Sewald X Gonzalez DG Haberman AM Mothes W In vivo imaging of virological synapses Nat Commun 2012 3 1320 10.1038/ncomms2338 23271654 PMC3784984 · DOI · Paper page
  59. [62]Murooka TT Deruaz M Marangoni F Vrbanac VD Seung E von Andrian UH HIV-infected T cells are migratory vehicles for viral dissemination Nature 2012 490 283 287 10.1038/nature11398 22854780 PMC3470742 · DOI · Paper page
  60. [63]Compton AA Schwartz O They might be giants: does syncytium formation sink or spread HIV infection? PLoS Pathog 2017 13 e1006099 10.1371/journal.ppat.1006099 28152024 PMC5289631 · DOI
  61. [64]Ladinsky MS Kieffer C Olson G Deruaz M Vrbanac V Tager AM Electron tomography of HIV-1 infection in gut-associated lymphoid tissue PLoS Pathog 2014 10 e1003899 10.1371/journal.ppat.1003899 24497830 PMC3907528 · DOI
  62. [65]Law KM Komarova NL Yewdall AW Lee RK Herrera OL Wodarz D In vivo HIV-1 cell-to-cell transmission promotes multicopy micro-compartmentalized infection Cell Rep 2016 15 2771 2783 10.1016/j.celrep.2016.05.059 27292632 · DOI · Paper page
  63. [66]Gousset K Ablan SD Coren LV Ono A Soheilian F Nagashima K Real-time visualization of HIV-1 GAG trafficking in infected macrophages PLoS Pathog 2008 4 e1000015 10.1371/journal.ppat.1000015 18369466 PMC2267008 · DOI
  64. [67]Groot F Welsch S Sattentau QJ Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses Blood 2008 111 4660 4663 10.1182/blood-2007-12-130070 18296630 · DOI
  65. [68]Duncan CJA Williams JP Schiffner T Gartner K Ochsenbauer C Kappes J High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse J Virol 2014 88 2025 2034 10.1128/JVI.03245-13 24307588 PMC3911534 · DOI
  66. [69]Wu L KewalRamani VN Dendritic-cell interactions with HIV: infection and viral dissemination Nat Rev Immunol 2006 6 859 868 10.1038/nri1960 17063186 PMC1796806 · DOI
  67. [70]Laguette N Sobhian B Casartelli N Ringeard M Chable-Bessia C Ségéral E SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx Nature 2011 474 654 657 10.1038/nature10117 21613998 PMC3595993 · DOI · Paper page
  68. [71]Goldstone DC Ennis-Adeniran V Hedden JJ Groom HCT Rice GI Christodoulou E HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase Nature 2011 480 379 382 10.1038/nature10623 22056990 · DOI
  69. [72]St Gelais C de Silva S Amie SM Coleman CM Hoy H Hollenbaugh JA SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4 + T-lymphocytes cannot be upregulated by interferons Retrovirology. 2012 9 105 10.1186/1742-4690-9-105 23231760 PMC3527137 · DOI
  70. [73]Manel N Hogstad B Wang Y Levy DE Unutmaz D Littman DR A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells Nature 2010 467 214 217 10.1038/nature09337 20829794 PMC3051279 · DOI · Paper page
  71. [74]Luban J Innate immune sensing of HIV-1 by dendritic cells Cell Host Microbe 2012 12 408 418 10.1016/j.chom.2012.10.002 23084911 PMC3619430 · DOI
  72. [75]Ayinde D Bruel T Cardinaud S Porrot F Prado JG Moris A SAMHD1 limits HIV-1 antigen presentation by monocyte-derived dendritic cells J Virol 2015 89 6994 7006 10.1128/JVI.00069-15 25926647 PMC4473575 · DOI
  73. [76]Lee B Sharron M Montaner LJ Weissman D Doms RW Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages Proc Natl Acad Sci 1999 96 5215 5220 10.1073/pnas.96.9.5215 10220446 PMC21844 · DOI
  74. [77]Chauveau L Donahue DA Monel B Porrot F Bruel T Richard L HIV fusion in dendritic cells occurs mainly at the surface and is limited by low CD4 levels J Virol 2017 91 e01248–17 10.1128/JVI.01248-17 28814521 PMC5640872 · DOI
  75. [78]Pelchen-Matthews A Kramer B Marsh M Infectious HIV-1 assembles in late endosomes in primary macrophages J Cell Biol 2003 162 443 455 10.1083/jcb.200304008 12885763 PMC2172706 · DOI
  76. [79]Deneka M Pelchen-Matthews A Byland R Ruiz-Mateos E Marsh M In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53 J Cell Biol 2007 177 329 341 10.1083/jcb.200609050 17438075 PMC2064140 · DOI
  77. [80]Gaudin R Berre S Cunha de Alencar B Decalf J Schindler M Gobert F-X Dynamics of HIV-containing compartments in macrophages reveal sequestration of virions and transient surface connections PLoS ONE 2013 8 e69450 10.1371/journal.pone.0069450 23922713 PMC3726685 · DOI
  78. [81]Cameron PU Freudenthal PS Barker JM Gezelter S Inaba K Steinman RM Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4 + T cells Science 1992 257 383 387 10.1126/science.1352913 1352913 · DOI
  79. [82]Hladik F McElrath MJ Setting the stage: host invasion by HIV Nat Rev Immunol 2008 8 447 457 10.1038/nri2302 18469831 PMC2587276 · DOI
  80. [83]Geijtenbeek TB Kwon DS Torensma R van Vliet SJ van Duijnhoven GC Middel J DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells Cell 2000 100 587 597 10.1016/S0092-8674(00)80694-7 10721995 · DOI · Paper page
  81. [85]Garcia E Pion M Pelchen-Matthews A Collinson L Arrighi J-F Blot G HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse: HIV-1 localization in human dendritic cells Traffic. 2005 6 488 501 10.1111/j.1600-0854.2005.00293.x 15882445 · DOI
  82. [86]Nobile C Petit C Moris A Skrabal K Abastado J-P Mammano F Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes J Virol 2005 79 5386 5399 10.1128/JVI.79.9.5386-5399.2005 15827153 PMC1082762 · DOI · Paper page
  83. [88]Puryear WB Akiyama H Geer SD Ramirez NP Yu X Reinhard BM Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on siglec-1/CD169 PLoS Pathog 2013 9 e1003291 10.1371/journal.ppat.1003291 23593001 PMC3623718 · DOI · Paper page
  84. [89]Akiyama H Ramirez N-GP Gudheti MV Gummuluru S CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies PLoS Pathog 2015 11 e1004751 10.1371/journal.ppat.1004751 25760631 PMC4356592 · DOI · Paper page
  85. [90]Hammonds JE Beeman N Ding L Takushi S Francis AC Wang J-J Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1 PLoS Pathog 2017 13 e1006181 10.1371/journal.ppat.1006181 28129379 PMC5298340 · DOI · Paper page
  86. [92]McDonald D Wu L Bohks SM KewalRamani VN Unutmaz D Hope TJ Recruitment of HIV and its receptors to dendritic cell-T cell junctions Science 2003 300 1295 1297 10.1126/science.1084238 12730499 · DOI · Paper page
  87. [93]Ménager MM Littman DR Actin Dynamics regulates dendritic cell-mediated transfer of HIV-1 to T cells Cell 2016 164 695 709 10.1016/j.cell.2015.12.036 26830877 PMC4752894 · DOI
  88. [94]Wiley RD Gummuluru S Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection Proc Natl Acad Sci 2006 103 738 743 10.1073/pnas.0507995103 16407131 PMC1334656 · DOI
  89. [96]See P Dutertre C-A Chen J Günther P McGovern N Irac SE Mapping the human DC lineage through the integration of high-dimensional techniques Science 2017 356 eaag3009 10.1126/science.aag3009 28473638 PMC7611082 · DOI
  90. [97]Silvin A Yu CI Lahaye X Imperatore F Brault J-B Cardinaud S Constitutive resistance to viral infection in human CD141+ dendritic cells Sci Immunol 2017 2 eaai8071 10.1126/sciimmunol.aai8071 28783704 PMC5749640 · DOI
  91. [100]Hashimoto M Bhuyan F Hiyoshi M Noyori O Nasser H Miyazaki M Potential role of the formation of tunneling nanotubes in HIV-1 spread in macrophages J Immunol 2016 196 1832 1841 10.4049/jimmunol.1500845 26773158 · DOI · Paper page
  92. [101]Kadiu I Gendelman HE Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network J Proteome Res 2011 10 3225 3238 10.1021/pr200262q 21563830 PMC3128463 · DOI
  93. [103]Nikolic DS Lehmann M Felts R Garcia E Blanchet FP Subramaniam S HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation Blood 2011 118 4841 4852 10.1182/blood-2010-09-305417 21562048 PMC3208294 · DOI
  94. [104]Aggarwal A Iemma TL Shih I Newsome TP McAllery S Cunningham AL Mobilization of HIV spread by diaphanous 2 dependent filopodia in infected dendritic cells PLoS Pathog 2012 8 e1002762 10.1371/journal.ppat.1002762 22685410 PMC3369929 · DOI · Paper page
  95. [105]Baxter AE Russell RA Duncan CJA Moore MD Willberg CB Pablos JL Macrophage infection via selective capture of HIV-1-infected CD4 + T cells Cell Host Microbe 2014 16 711 721 10.1016/j.chom.2014.10.010 25467409 PMC4271767 · DOI
  96. [106]Bracq L Xie M Lambelé M Vu L-T Matz J Schmitt A T cell-macrophage fusion triggers multinucleated giant cell formation for HIV-1 spreading J Virol 2017 91 e01237–17 10.1128/JVI.01237-17 PMC5709600 28978713 · DOI
  97. [107]Alfsen A Yu H Magérus-Chatinet A Schmitt A Bomsel M HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer MBoC. 2005 16 4267 4279 10.1091/mbc.e05-03-0192 PMC1196336 15975901 · DOI
  98. [108]Real F Sennepin A Ganor Y Schmitt A Bomsel M Live imaging of HIV-1 transfer across T cell virological synapse to epithelial cells that promotes stromal macrophage infection Cell Rep 2018 23 1794 1805 10.1016/j.celrep.2018.04.028 29742434 · DOI
  99. [109]Gupta P Balachandran R Ho M Enrico A Rinaldo C Cell-to-cell transmission of human immunodeficiency virus type 1 in the presence of azidothymidine and neutralizing antibody J Virol 1989 63 2361 2365 2704079 PMC250658
  100. [110]Durham ND Yewdall AW Chen P Lee R Zony C Robinson JE Neutralization resistance of virological synapse-mediated HIV-1 infection is regulated by the gp41 cytoplasmic tail J Virol 2012 86 7484 7495 10.1128/JVI.00230-12 22553332 PMC3416307 · DOI
  101. [111]Sánchez-Palomino S Massanella M Carrillo J García A García F González N A cell-to-cell HIV transfer assay identifies humoral responses with broad neutralization activity Vaccine. 2011 29 5250 5259 10.1016/j.vaccine.2011.05.016 21609746 · DOI
  102. [112]Purtscher M Trkola A Gruber G Buchacher A Predl R Steindl F A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1 AIDS Res Hum Retroviruses 1994 10 1651 1658 10.1089/aid.1994.10.1651 7888224 · DOI
  103. [113]Pantaleo G Demarest JF Vaccarezza M Graziosi C Bansal GP Koenig S Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission Eur J Immunol 1995 25 226 231 10.1002/eji.1830250137 7843235 · DOI
  104. [114]Massanella M Puigdomènech I Cabrera C Fernandez-Figueras MT Aucher A Gaibelet G Antigp41 antibodies fail to block early events of virological synapses but inhibit HIV spread between T cells AIDS. 2009 23 183 188 10.1097/QAD.0b013e32831ef1a3 19098487 · DOI
  105. [115]Abela IA Berlinger L Schanz M Reynell L Günthard HF Rusert P Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies PLoS Pathog 2012 8 e1002634 10.1371/journal.ppat.1002634 22496655 PMC3320602 · DOI
  106. [116]Malbec M Porrot F Rua R Horwitz J Klein F Halper-Stromberg A Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission J Exp Med 2013 210 2813 2821 10.1084/jem.20131244 24277152 PMC3865481 · DOI
  107. [117]Reh L Magnus C Schanz M Weber J Uhr T Rusert P Capacity of broadly neutralizing antibodies to inhibit HIV-1 cell-cell transmission is strain- and epitope-dependent PLoS Pathog 2015 11 e1004966 10.1371/journal.ppat.1004966 26158270 PMC4497647 · DOI
  108. [118]Gombos RB Kolodkin-Gal D Eslamizar L Owuor JO Mazzola E Gonzalez AM Inhibitory effect of individual or combinations of broadly neutralizing antibodies and antiviral reagents against cell-free and cell-to-cell HIV-1 transmission J Virol 2015 89 7813 7828 10.1128/JVI.00783-15 25995259 PMC4505680 · DOI
  109. [119]Li H Zony C Chen P Chen BK Reduced potency and incomplete neutralization of broadly neutralizing antibodies against cell-to-cell transmission of HIV-1 with transmitted founder Envs J Virol 2017 91 e02425–16 10.1128/JVI.02425-16 28148796 PMC5391450 · DOI
  110. [120]Martin N Welsch S Jolly C Briggs JAG Vaux D Sattentau QJ Virological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibition J Virol 2010 84 3516 3527 10.1128/JVI.02651-09 20089656 PMC2838118 · DOI · Paper page
  111. [121]Frankel SS Steinman RM Michael NL Kim SR Bhardwaj N Pope M Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to T cells J Virol 1998 72 9788 9794 9811714 PMC110490
  112. [122]Ganesh L Leung K Lore K Levin R Panet A Schwartz O Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies J Virol 2004 78 11980 11987 10.1128/JVI.78.21.11980-11987.2004 15479838 PMC523246 · DOI
  113. [123]van Montfort T Nabatov AA Geijtenbeek TBH Pollakis G Paxton WA Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4 + T lymphocytes J Immunol 2007 178 3177 3185 10.4049/jimmunol.178.5.3177 17312166 · DOI
  114. [124]Su B Xu K Lederle A Peressin M Biedma ME Laumond G Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes Blood 2012 120 3708 3717 10.1182/blood-2012-03-418913 22955927 · DOI
  115. [125]Su B Lederle A Laumond G Ducloy C Schmidt S Decoville T Broadly neutralizing antibody VRC01 prevents HIV-1 transmission from plasmacytoid dendritic cells to CD4 T lymphocytes J Virol 2014 88 10975 10981 10.1128/JVI.01748-14 24965460 PMC4178849 · DOI
  116. [126]Sagar M Akiyama H Etemad B Ramirez N Freitas I Gummuluru S Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection J Infect Dis 2012 205 1248 1257 10.1093/infdis/jis183 22396600 PMC3308909 · DOI
  117. [127]McCoy LE Groppelli E Blanchetot C de Haard H Verrips T Rutten L Neutralisation of HIV-1 cell-cell spread by human and llama antibodies Retrovirology. 2014 11 83 10.1186/s12977-014-0083-y 25700025 PMC4189184 · DOI
  118. [128]Koppensteiner H Banning C Schneider C Hohenberg H Schindler M Macrophage internal HIV-1 Is protected from neutralizing antibodies J Virol 2012 86 2826 2836 10.1128/JVI.05915-11 22205742 PMC3302290 · DOI
  119. [129]Cohen YZ Lorenzi JCC Seaman MS Nogueira L Schoofs T Krassnig L Neutralizing activity of broadly neutralizing anti-HIV-1 antibodies against clade B clinical isolates produced in peripheral blood mononuclear cells J Virol 2017 92 e01883–17 10.1128/JVI.01883-17 PMC5809738 29237833 · DOI
  120. [130]Fortin JF Cantin R Lamontagne G Tremblay M Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity J Virol 1997 71 3588 3596 9094631 PMC191506
  121. [131]Fortin J-F Cantin R Tremblay MJ T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1 J Virol 1998 72 2105 2112 9499066 PMC109505
  122. [132]Fortin J-F Cantin R Bergeron MG Tremblay MJ Interaction between virion-bound host intercellular adhesion molecule-1 and the high-affinity state of lymphocyte function-associated antigen-1 on target cells renders R5 and X4 isolates of human immunodeficiency virus type 1 more refractory to neutralization Virology 2000 268 493 503 10.1006/viro.2000.0190 10704357 · DOI
  123. [133]Chojnacki J Staudt T Glass B Bingen P Engelhardt J Anders M Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy Science 2012 338 524 528 10.1126/science.1226359 23112332 · DOI
  124. [134]Veillette M Desormeaux A Medjahed H Gharsallah N-E Coutu M Baalwa J Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity J Virol 2014 88 2633 2644 10.1128/JVI.03230-13 24352444 PMC3958102 · DOI
  125. [135]Bruel T Guivel-Benhassine F Lorin V Lortat-Jacob H Baleux F Bourdic K Lack of ADCC breadth of human nonneutralizing anti-HIV-1 antibodies J Virol 2017 91 e02440–16 10.1128/JVI.02440-16 28122982 PMC5375671 · DOI
  126. [136]Schwartz O Maréchal V Danos O Heard JM Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell J Virol 1995 69 4053 4059 7539505 PMC189139
  127. [137]Neil SJD Zang T Bieniasz PD Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu Nature 2008 451 425 430 10.1038/nature06553 18200009 · DOI
  128. [138]Lai RPJ Yan J Heeney J McClure MO Göttlinger H Luban J Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41 PLoS Pathog 2011 7 e1002442 10.1371/journal.ppat.1002442 22194689 PMC3240605 · DOI
  129. [139]Joyner AS Willis JR Crowe JE Aiken C Maturation-induced cloaking of neutralization epitopes on HIV-1 particles PLoS Pathog 2011 7 e1002234 10.1371/journal.ppat.1002234 21931551 PMC3169560 · DOI
  130. [140]Chen J Kovacs JM Peng H Rits-Volloch S Lu J Park D Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein Science 2015 349 191 195 10.1126/science.aaa9804 26113642 PMC4701381 · DOI
  131. [141]Durham ND Chen BK HIV-1 cell-free and cell-to-cell infections are differentially regulated by distinct determinants in the Env gp41 cytoplasmic tail J Virol 2015 89 9324 9337 10.1128/JVI.00655-15 26136566 PMC4542346 · DOI
  132. [142]Lu LL Suscovich TJ Fortune SM Alter G Beyond binding: antibody effector functions in infectious diseases Nat Rev Immunol 2017 18 46 61 10.1038/nri.2017.106 29063907 PMC6369690 · DOI
  133. [143]von Bredow B Arias JF Heyer LN Moldt B Le K Robinson JE Comparison of antibody-dependent cell-mediated cytotoxicity and virus neutralization by HIV-1 Env-specific monoclonal antibodies J Virol 2016 90 6127 6139 10.1128/JVI.00347-16 27122574 PMC4907221 · DOI
  134. [144]Lee WS Kent SJ Anti-HIV-1 antibody-dependent cellular cytotoxicity: is there more to antibodies than neutralization? Curr Opin HIV AIDS 2018 13 160 166 10.1097/COH.0000000000000439 29194123 · DOI
  135. [145]Richard J Prévost J Alsahafi N Ding S Finzi A Impact of HIV-1 envelope conformation on ADCC responses Trends Microbiol. 2018 26 4 253 265 10.1016/j.tim.2017.10.007 29162391 · DOI
  136. [146]Hessell AJ Hangartner L Hunter M Havenith CEG Beurskens FJ Bakker JM Fc receptor but not complement binding is important in antibody protection against HIV Nature 2007 449 101 104 10.1038/nature06106 17805298 · DOI
  137. [147]Bournazos S Klein F Pietzsch J Seaman MS Nussenzweig MC Ravetch JV Broadly neutralizing anti-HIV-1 antibodies require fc effector functions for in vivo activity Cell 2014 158 1243 1253 10.1016/j.cell.2014.08.023 25215485 PMC4167398 · DOI
  138. [148]Horwitz JA Halper-Stromberg A Mouquet H Gitlin AD Tretiakova A Eisenreich TR HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice Proc Natl Acad Sci 2013 110 16538 16543 10.1073/pnas.1315295110 24043801 PMC3799352 · DOI
  139. [149]Horwitz JA Bar-On Y Lu C-L Fera D Lockhart AAK Lorenzi JCC Non-neutralizing antibodies alter the course of HIV-1 infection in vivo Cell 2017 170 637–648 e10 PMC5554461 28757252
  140. [150]Prévost J Richard J Ding S Pacheco B Charlebois R Hahn BH Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals Virology 2018 515 38 45 10.1016/j.virol.2017.12.002 29248757 PMC5843759 · DOI
  141. [151]Ndirangu J Viljoen J Bland RM Danaviah S Thorne C Van de Perre P Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding PLoS ONE 2012 7 e51493 10.1371/journal.pone.0051493 23284701 PMC3532207 · DOI
  142. [152]Bernard-Stoecklin S Gommet C Corneau AB Guenounou S Torres C Dejucq-Rainsford N Semen CD4 + T cells and macrophages are productively infected at all stages of SIV infection in Macaques PLoS Pathog 2013 9 e1003810 10.1371/journal.ppat.1003810 24348253 PMC3861532 · DOI
  143. [153]Zhu T Wang N Carr A Nam DS Moor-Jankowski R Cooper DA Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission J Virol 1996 70 3098 3107 8627789 PMC190172
  144. [154]Sallé B Brochard P Bourry O Mannioui A Andrieu T Prevot S Infection of Macaques after vaginal exposure to cell-associated simian immunodeficiency virus J Infect Dis 2010 202 337 344 10.1086/653619 20569157 · DOI
  145. [155]Kolodkin-Gal D Hulot SL Korioth-Schmitz B Gombos RB Zheng Y Owuor J Efficiency of cell-free and cell-associated virus in mucosal transmission of human immunodeficiency virus type 1 and simian immunodeficiency virus J Virol 2013 87 13589 13597 10.1128/JVI.03108-12 24109227 PMC3838232 · DOI
  146. [156]Parsons MS Lloyd SB Lee WS Kristensen AB Amarasena T Center RJ Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infection Sci Transl Med 2017 9 eaaf1483 10.1126/scitranslmed.aaf1483 28794282 · DOI
  147. [157]Titanji BK Pillay D Jolly C Combination antiretroviral therapy and cell–cell spread of wild-type and drug-resistant human immunodeficiency virus-1 J Gen Virol 2017 98 821 834 10.1099/jgv.0.000728 28141491 PMC5657029 · DOI

Cited by

Sorted by citations

Authors
Dufloo, J., Bruel, T., & Schwartz, O.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Schwartz, Olivier
ORCID
Venue
Retrovirology
Publisher
Springer Science and Business Media LLC
Published
2018-07-28
Volume
15
Issue
1
Pages
51-51
ISSN
1742-4690 (ISSN-L)
DOI
10.1186/s12977-018-0434-1
PMC
PMC6064125
OpenAlex
W2883776741
Cited by
69
References
10
Citations by year
2026: 8 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 13 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 3
FWCI
1.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Retrovirology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • L'Oreal USA
  • Gilead Sciences
  • Sidaction
  • Agence Nationale de la Recherche (ANR-10-LABX-77, ANR-10-IHUB-0002, ANR-14-CE14-0015, ANR-14-CE14-0029, CE14-0029, ANR-10-LABX-0077, CE14-0015-01, ANR-10, ANR-10-LABX-0062)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords
HIV-1, cell-to-cell transmission, broadly neutralizing antibodies, virological synapse, viral envelope glycoprotein, nanotubes, filopodia, immune evasion, viral budding, antibody mechanism of action
MeSH terms
Animals, Humans, Macrophages, Models, Biological, Synapses, HIV Antibodies, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, env Gene Products, Human Immunodeficiency Virus, Immune Evasion, Antibodies, Neutralizing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review