Relating neuronal firing patterns to functional differentiation of cerebral cortex.
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It has been empirically established that the cerebral cortical areas defined by Brodmann one hundred years ago solely on the basis of cellular organization are closely correlated to their function, such as sensation, association, and motion. Cytoarchitectonically distinct cortical areas have different densities and types of neurons. Thus, signaling patterns may also vary among cytoarchitectonically unique cortical areas. To examine how neuronal signaling patterns are related to innate cortical functions, we detected intrinsic features of cortical firing by devising a metric that efficiently isolates non-Poisson irregular characteristics, independent of spike rate fluctuations that are caused extrinsically by ever-changing behavioral conditions. Using the new metric, we analyzed spike trains from over 1,000 neurons in 15 cortical areas sampled by eight independent neurophysiological laboratories. Analysis of firing-pattern dissimilarities across cortical areas revealed a gradient of firing regularity that corresponded closely to the functional category of the cortical area; neuronal spiking patterns are regular in motor areas, random in the visual areas, and bursty in the prefrontal area. Thus, signaling patterns may play an important role in function-specific cerebral cortical computation.
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Similar ISI distributions were observed during in-vivo recordings in awake, behaving monkeys.
“Similar ISI distributions were observed during in-vivo recordings in awake, behaving monkeys [67].”
From Neural dynamics as sampling: a model for stochastic computation in recurrent networks of spiking neurons (2011) · cites this paper as [67]
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A characterization of the time-rescaled gamma process as a model for spike trains
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Self-citationSimple Cortical and Thalamic Neuron Models for Digital Arithmetic Circuit Implementation
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- Authors
- Shinomoto, S., Kim, H., Shimokawa, T., Matsuno, N., Funahashi, S., Shima, K., Fujita, I., Tamura, H., Doi, T., Kawano, K., Inaba, N., Fukushima, K., Kurkin, S., Kurata, K., Taira, M., Tsutsui, K.-I., Komatsu, H., Ogawa, T., Koida, K., Tanji, J., & Toyama, K.
- Affiliations
- Kyoto University (JP)
- Tohoku University (JP)
- The University of Osaka (JP)
- Hokkaido University (JP)
- Hirosaki University (JP)
- Nihon University (JP)
- National Institute for Physiological Sciences (JP)
- Brain Science Institute, Tamagawa University (JP)
- Advanced Telecommunications Research Institute International (JP)
- Corresponding author
- Shinomoto, Shigeru
- ORCID
- Venue
- PLoS Computational Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-07-10
- Volume
- 5
- Issue
- 7
- Pages
- e1000433
- ISSN
- 1553-734X (ISSN-L)
- 1553-7358
- PMC
- PMC2701610
- OpenAlex
- W1978668587
- Cited by
- 239
- References
- 77
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 10 · 2023: 13 · 2022: 15 · 2021: 19 · 2020: 17 · 2019: 15 · 2018: 15 · 2017: 12 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 17 · 2012: 14
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Computational Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (20020012)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- neuronal firing patterns, cerebral cortex, motor cortex, visual cortex, prefrontal cortex, Brodmann areas, cytoarchitecture
- MeSH terms
- Action Potentials, Animals, Haplorhini, Brain Mapping, Cerebral Cortex, Models, Neurological, Neurons, Regression Analysis, Cluster Analysis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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