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Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins
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“Interestingly, contrary to previous expectations, most mtDNA mutations in adult or aged cells appear to be caused by replication errors early in life, rather than by oxidative damage.”
From The Hallmarks of Aging (2013) · cites this paper as Ameur et al., 2011
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“These mutations may undergo polyclonal expansion and cause respiratory chain dysfunction in different tissues (Ameur et al., 2011).”
From The Hallmarks of Aging (2013) · cites this paper as Ameur et al., 2011
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Cites
Premature ageing in mice expressing defective mitochondrial DNA polymerase
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Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
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Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246
Parkinson’s disease as a result of aging
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Metadata
- Authors
- Ameur, A., Stewart, J. B., Freyer, C., Hagström, E., Ingman, M., Larsson, N.-G., & Gyllensten, U.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-03-24
- Volume
- 7
- Issue
- 3
- Pages
- e1002028
- ISSN
- 1553-7404
- PMC
- PMC3063763
- Cited by
- 187
- References
- 2
- Language
- en
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