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Cited by 1,347

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Serum MicroRNAs Are Promising Novel Biomarkers

Open access
Gilad, Shlomit, Meiri, Eti, Yogev, Yariv, Benjamin, Sima, Lebanony, Danit, Yerushalmi, Noga, Benjamin, Hila, Kushnir, Michal, Cholakh, Hila, Melamed, Nir, Bentwich, Zvi, Hod, Moshe, Goren, Yaron, Chajut, Ayelet·2008·PLoS ONE
DOI 10.1371/journal.pone.0003148
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Abstract

BACKGROUND: Circulating nucleic acids (CNAs) offer unique opportunities for early diagnosis of clinical conditions. Here we show that microRNAs, a family of small non-coding regulatory RNAs involved in human development and pathology, are present in bodily fluids and represent new effective biomarkers. METHODS AND RESULTS: After developing protocols for extracting and quantifying microRNAs in serum and other body fluids, the serum microRNA profiles of several healthy individuals were determined and found to be similar, validating the robustness of our methods. To address the possibility that the abundance of specific microRNAs might change during physiological or pathological conditions, serum microRNA levels in pregnant and non pregnant women were compared. In sera from pregnant women, microRNAs associated with human placenta were significantly elevated and their levels correlated with pregnancy stage. CONCLUSIONS AND SIGNIFICANCE: Considering the central role of microRNAs in development and disease, our results highlight the medically relevant potential of determining microRNA levels in serum and other body fluids. Thus, microRNAs are a new class of CNAs that promise to serve as useful clinical biomarkers.

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Metadata

Authors
Gilad, S., Meiri, E., Yogev, Y., Benjamin, S., Lebanony, D., Yerushalmi, N., Benjamin, H., Kushnir, M., Cholakh, H., Melamed, N., Bentwich, Z., Hod, M., Goren, Y., & Chajut, A.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2008-09-05
Volume
3
Issue
9
Pages
e3148
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0003148
OpenAlex
W2163482204
Cited by
1,347
References
1
FWCI
24.97
Type
journal article
Language
en
Open access
gold

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