Common and distinct neural substrates for pragmatic, semantic, and syntactic processing of spoken sentences: an fMRI study

Kuperberg, G. R.; McGuire, P. K.; Bullmore, E. T.; Brammer, M. J.; Rabe-Hesketh, S.; Wright, I. C.; Lythgoe, D. J.; Williams, S. C. R.; David, A. S.

doi:10.1162/089892900562138

Cited by 305Neurobiology of Language and BilingualismLanguage Development and DisordersReading and Literacy Development

Common and distinct neural substrates for pragmatic, semantic, and syntactic processing of spoken sentences: an fMRI study

Kuperberg, G. R., McGuire, P. K., Bullmore, E. T., Brammer, M. J., Rabe-Hesketh, S., Wright, I. C., Lythgoe, D. J., Williams, S. C. R. +1 more·2000·Journal of Cognitive Neuroscience

DOI 10.1162/089892900562138

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Abstract

Extracting meaning from speech requires the use of pragmatic, semantic, and syntactic information. A central question is: Does the processing of these different types of linguistic information have common or distinct neuroanatomical substrates? We addressed this issue using functional magnetic resonance imaging (fMRI) to measure neural activity when subjects listened to spoken normal sentences contrasted with sentences that had either (A) pragmatical, (B) semantic (selection restriction), or (C) syntactic (subcategorical) violations sentences. All three contrasts revealed robust activation of the left-inferior-temporal/fusiform gyrus. Activity in this area was also observed in a combined analysis of all three experiments, suggesting that it was modulated by all three types of linguistic violation. Planned statistical comparisons between the three experiments revealed (1) a greater difference between conditions in activation of the left-superior-temporal gyrus for the pragmatic experiment than the semantic/syntactic experiments; (2) a greater difference between conditions in activation of the right-superior and middle-temporal gyrus in the semantic experiment than in the syntactic experiment; and (3) no regions activated to a greater degree in the syntactic experiment than in the semantic experiment. These data show that, while left- and right-superior-temporal regions may be differentially involved in processing pragmatic and lexico-semantic information within sentences, the left-inferior-temporal/fusiform gyrus is involved in processing all three types of linguistic information. We suggest that this region may play a key role in using pragmatic, semantic (selection restriction), and subcategorical information to construct a higher representation of meaning of sentences.

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Other studies did not show such a clear cut dissociation between semantic and syntactic processing.
“However, other studies did not show such a clear cut dissociation between semantic and syntactic processing (Kuperberg et al., 2000; Tyler et al., 2001).”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Kuperberg et al., 2000

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Authors: Kuperberg, G. R., McGuire, P. K., Bullmore, E. T., Brammer, M. J., Rabe-Hesketh, S., Wright, I. C., Lythgoe, D. J., Williams, S. C. R., & David, A. S.
Affiliations: Institute of Psychiatry, London
University of Cambridge (GB)
ORCID: Kuperberg, G. R.
McGuire, P. K.
Bullmore, E. T.
Wright, I. C.
Lythgoe, D. J.
Williams, S. C. R.
David, A. S.
Venue: Journal of Cognitive Neuroscience
Publisher: MIT Press
Published: 2000-03-01
Volume: 12
Issue: 2
Pages: 321-341
ISSN: 0898-929X (ISSN-L)
1530-8898
DOI: 10.1162/089892900562138
OpenAlex: W2118992292
Cited by: 305
References: 110
Citations by year: 2026: 4 · 2025: 2 · 2024: 14 · 2023: 10 · 2022: 3 · 2021: 9 · 2020: 7 · 2019: 10 · 2018: 5 · 2017: 14 · 2016: 10 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 19
FWCI: 7.70
Type: journal article
Language: en
Open access: closed
Locations: Journal of Cognitive Neuroscience (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
Keywords: pragmatic processing, semantic processing, syntactic processing, spoken sentence comprehension, neural correlates, selection restrictions, subcategorization, fusiform gyrus, superior temporal gyrus, temporal lobe
MeSH terms: Brain, Brain Mapping, Cognition, Humans, Linguistics, Magnetic Resonance Imaging, Male, Semantics, Speech, Reproducibility of Results

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Common and distinct neural substrates for pragmatic, semantic, and syntactic processing of spoken sentences: an fMRI study

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