Regression of Atherosclerosis Is Characterized by Broad Changes in the Plaque Macrophage Transcriptome

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Regression of Atherosclerosis: The Journey From the Liver to the Plaque and Back.

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miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

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Liraglutide Attenuates Preestablished Atherosclerosis in Apolipoprotein E–Deficient Mice via Regulation of Immune Cell Phenotypes and Proinflammatory Mediators

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Monocytes and macrophages in atherogenesis

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The Entry and Egress of Monocytes in Atherosclerosis: A Biochemical and Biomechanical Driven Process

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Plasma proteome profiling of atherosclerotic disease manifestations reveals elevated levels of the cytoskeletal protein vinculin

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Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression

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Role of AGEs in the progression and regression of atherosclerotic plaques

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Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

Ramsey, S., Vengrenyuk, Y., Menon, P., Podolsky, I., Feig, J. E., Aderem, A., Fisher, E., & Gold, E. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004828 · Cited by 36 · see citing works

The phenomenon of atherosclerosis reversal and regression: Lessons from animal models

Chistiakov, D. A., Myasoedova, V. A., Ревин, В. В., Orekhov, A. N., & Bobryshev, Y. V. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.01.013 · Cited by 40 · see citing works

Clinical significance of macrophage phenotypes in cardiovascular disease

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Use of Mouse Models in Atherosclerosis Research.

Getz, G., & Reardon, C. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2929-0_1 · Cited by 37 · see citing works

Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes

Swart, M., & Troeberg, L. (2018) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155418798770 · Cited by 33 · see citing works

Deletion of Myeloid GSK3α Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype

McAlpine, C. S., Huang, A., Emdin, A. L., Banko, N. S., Beriault, D. R., Shi, Y., & Werstuck, G. H. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305438 · Cited by 32 · see citing works

Cholesterol lowering depletes atherosclerotic lesions of smooth muscle cell-derived fibromyocytes and chondromyocytes

Carramolino, L., Albarrán-Juárez, J., Markov, A., Hernández‐SanMiguel, E., Sharysh, D., Cumbicus, V., Morales‐Cano, D., Labrador-Cantarero, V., Møller, P. L., Nogales, P., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00412-w · Cited by 31 · see citing works

Differential Gene Expression in Macrophages From Human Atherosclerotic Plaques Shows Convergence on Pathways Implicated by Genome-Wide Association Study Risk Variants

Chai, J. T., Ruparelia, N., Goel, A., Kyriakou, T., Biasiolli, L., Edgar, L., Handa, A. I., Farrall, M., Watkins, H. C., & Choudhury, R. P. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311209 · Cited by 30 · see citing works

Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis

Lee, J., & Choi, J. (2020) · Immune Network · doi:10.4110/in.2020.20.e22 · Cited by 30 · see citing works

Remote sensing tree classification with a multilayer perceptron

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10,12 Conjugated Linoleic Acid-Driven Weight Loss Is Protective against Atherosclerosis in Mice and Is Associated with Alternative Macrophage Enrichment in Perivascular Adipose Tissue

Kanter, J. E., Goodspeed, L., Wang, S., Kramer, F., Wietecha, T., Kjerulf, D. G., Subramanian, S., O’Brien, K. D., & den Hartigh, L. J. (2018) · Nutrients · doi:10.3390/nu10101416 · Cited by 28 · see citing works

Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation

Wu, C., Hussein, M. A., Shrestha, E., Leone, S., Aiyegbo, M. S., Lambert, W. M., Pourcet, B., Cardozo, T. J., Gustafson, J.-A., Fisher, E. A. A., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00985-14 · Cited by 26 · see citing works

High density lipoprotein and metabolic disease: Potential benefits of restoring its functional properties

Klančič, T., Woodward, L., Hofmann, S. M., & Fisher, E. A. A. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.03.001 · Cited by 26 · see citing works

Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K/Akt/NF-κB signalling pathway

Luo, L., Liang, H., & Liu, L. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.2010775 · Cited by 25 · see citing works

Genotype-Dependent Impairment of Hemoglobin Clearance Increases Oxidative and Inflammatory Response in Human Diabetic Atherosclerosis

Meerarani, P., Krishnan, P., Purushothaman, K., Baber, U., Tarricone, A. N., Pérez, J. S., Wiley, J. M., Kini, A. S., Sharma, S. K., Fuster, V., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.252122 · Cited by 23 · see citing works

The role of HDL in plaque stabilization and regression

Feig, J. E., Feig, J. L., & Dangas, G. (2016) · Coronary Artery Disease · doi:10.1097/mca.0000000000000408 · Cited by 24 · see citing works

Reshaping of the gastrointestinal microbiome alters atherosclerotic plaque inflammation resolution in mice

Garshick, M. S., Nikain, C. A., Tawil, M., Pena, S., Barrett, T. J., Wu, B. G., Gao, Z., Blaser, M. J., & Fisher, E. A. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-88479-y · Cited by 22 · see citing works

Recent Developments in the Role of Protein Tyrosine Phosphatase 1B (PTP1B) as a Regulator of Immune Cell Signalling in Health and Disease

Read, N., & Wilson, H. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137207 · Cited by 22 · see citing works

Moving from lipids to leukocytes: inflammation and immune cells in atherosclerosis

Annink, M. E., Kraaijenhof, J. M., Stroes, E. S. G., & Kroon, J. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1446758 · Cited by 21 · see citing works

The Semaphorin 3E/PlexinD1 Axis Regulates Macrophage Inflammation in Obesity

Schmidt, A. M., & Moore, K. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.011 · Cited by 21 · see citing works

Regression of atherosclerosis: lessons learned from genetically modified mouse models

Burke, A. C., & Huff, M. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000493 · Cited by 20 · see citing works

Unravelling the role of macrophages in cardiovascular inflammation through imaging: a state-of-the-art review

Parry, R., Majeed, K., Pixley, F. J., Hillis, G. S., Francis, R. J., & Schultz, C. J. (2022) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeac167 · Cited by 19 · see citing works

Statins, atherosclerosis regression and HDL: Insights from within the plaque

Feig, J. E., Feig, J. L., & Kini, A. S. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.036 · Cited by 19 · see citing works

Calcification and Inflammation in Atherosclerosis

Nakahara, T., Narula, J., & Strausś, H. W. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.11.014 · Cited by 19 · see citing works

Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice

Vurusaner, B., Thevkar-Nages, P., Kaur, R., Giannarelli, C., Garabedian, M. J., & Fisher, E. A. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-15349-6 · Cited by 18 · see citing works

Functional characterization of interleukin 4 and retinoic acid signaling crosstalk during alternative macrophage activation

Pinos, I., Yu, J., Pilli, N. R., Kane, M. A., & Amengual, J. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2023.159291 · Cited by 12 · see citing works

Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation

Lin, M., Zhao, L. B., Zhao, W., & WENG, J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1960 · Cited by 14 · see citing works

Mental health progress requires causal diagnostic nosology and scalable causal discovery

Saxe, G., Bickman, L., Ma, S., & Aliferis, C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.898789 · Cited by 13 · see citing works

From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review)

Li, T., Feng, W., Yan, W., & Wang, T. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13269 · Cited by 13 · see citing works

Insights into the role of the resolvin D2-GPR18 signaling axis in cardiovascular physiology and disease

Spite, M. R., & Fredman, G. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2022.12.005 · Cited by 13 · see citing works

Inflammation reprogramming and immunomodulation: Next-generation treatments for atherosclerosis

Choudhury, R. P., Hargreaves, R., Chai, J., & Fisher, E. A. A. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102288 · Cited by 12 · see citing works

The impact of the PCSK-9/VLDL-Receptor axis on inflammatory cell polarization

Barcena, M. L., Estepa, M., Marx, L., Breiter, A., Haritonow, N., & Stawowy, P. (2022) · Cytokine · doi:10.1016/j.cyto.2022.156077 · Cited by 12 · see citing works

Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apobtm2Sgy/Ldlrtm1Her/J mice

Thota, L. N., Ponnusamy, T., Philip, S., Lu, X., & Mundkur, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-04183-w · Cited by 12 · see citing works

Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism

Zhong, Z., Li, B., Li, C. R., Zhang, Q., Liu, Z. D., Zhang, P. F., Gu, X., Luo, H., Li, M., Luo, H. S., et al. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20144195 · Cited by 11 · see citing works

Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism

Helk, O., Dekeryte, R., Thompson, D., Kamli-Salino, S., Philip, S., Wilson, H. M., Mody, N., & Delibegović, M. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04598-2 · Cited by 9 · see citing works

Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis

Zhevlakova, I., Liu, H., Dudiki, T., Gao, D., Yakubenko, V. P., Tkachenko, S., Cherepanova, O. A., Podrez, E. A., & Byzova, T. V. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae223 · Cited by 7 · see citing works

Two-photon excited fluorescence (TPEF) may be useful to identify macrophage subsets based on their metabolic activity and cellular responses in atherosclerotic plaques

Borowczyk, C., Laroche‐Traineau, J., Brévier, J., Jacobin‐Valat, M., Marais, S., Gerbaud, É., Clofent‐Sanchez, G., & Ottonès, F. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.07.017 · Cited by 7 · see citing works

Understanding the role of alternative macrophage phenotypes in human atherosclerosis

Kawai, K., Vozenilek, A. E., Kawakami, R., Sato, Y., Ghosh, S., Virmani, R., & Finn, A. V. (2022) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2022.2111301 · Cited by 6 · see citing works

Obesity and atherosclerosis: the exosome link

Reiss, A. B., Glass, D. S., Voloshyna, I., Glass, A. D., Kasselman, L. J., & Leon, J. D. (2020) · Vessel Plus · doi:10.20517/2574-1209.2020.04 · Cited by 6 · see citing works

Potential beneficial effects of ixmyelocel-T in the treatment of atherosclerotic diseases

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Platelets impair the resolution of inflammation in atherosclerotic plaques in insulin-resistant mice after lipid lowering

Laskou, M., Delbare, S., Gildea, M., Weinstock, A., Virginio, V. D. M., Forest, M. L., Krautter, F., Donahoe, C., Amadori, L., Eberhardt, N., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.193593 · Cited by 4 · see citing works

The Macrophage Transcriptome

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Role of Autophagy in Atherogenesis

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Connecting Transcriptional and Functional Macrophage Heterogeneity in Atherosclerosis

Schlegel, M., Koelwyn, G. J., & Moore, K. J. (2019) · Circulation Research · doi:10.1161/circresaha.119.316168 · Cited by 2 · see citing works

Abstract 19264: Regression of Atherosclerosis is Characterized by Molecular Re-programming of the Transcriptome: Insights into the Identification of New Therapeutic Targets Against Cardiovascular Disease

Feig, J. E., Vengrenyuk, Y., Wu, C., Aliferis, C., Statnikov, A., Garabedian, M. J., Puig, Ó., & Fisher, E. A. A. (2012) · Circulation · doi:10.1161/circ.126.suppl_21.a19264

Abstract 1: Atherosclerosis Regression is Dependent Upon Newly Recruited Ly6c high Circulating Monocytes and Their STAT6-Mediated M2 Polarization

Rahman, K., Vengrenyuk, Y., Girgis, N. M., Rotllán, N., Liu, J. J., Moore, K. J., Loke, P., & Fisher, E. A. A. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.36.suppl_1.1

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

Rahman, K., Vengrenyuk, Y., Ramsey, S., Vila, N. R., Girgis, N., Liu, J.-H., Gusarova, V., Gromada, J., Weinstock, A., Moore, K., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci75005 · Cited by 311 · see citing works

Abstract 55: Recruitment of Ly6Chigh Monocytes is Required for the Enhancement of Anti-inflammatory (M2) Macrophage Phenotype in Atherosclerosis Regression in vivo

Vengrenyuk, Y., Girgis, N. M., Loke, P., & Fisher, E. A. A. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.33.suppl_1.a55

Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression

Peled, M., & Fisher, E. A. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00579 · Cited by 203 · see citing works