Interleukin‐13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype
Open accessAbstract
Atherosclerotic lesions are characterized by the accumulation of oxidized LDL (OxLDL) and the infiltration of macrophages and T cells. Cytokine expression in the microenvironment of evolving lesions can profoundly contribute to plaque development. While the pro-atherogenic effect of T helper (Th) 1 cytokines, such as IFN-γ, is well established, the role of Th2 cytokines is less clear. Therefore, we characterized the role of the Th2 cytokine interleukin (IL)-13 in murine atherosclerosis. Here, we report that IL-13 administration favourably modulated the morphology of already established atherosclerotic lesions by increasing lesional collagen content and reducing vascular cell adhesion molecule-1 (VCAM-1)-dependent monocyte recruitment, resulting in decreased plaque macrophage content. This was accompanied by the induction of alternatively activated (M2) macrophages, which exhibited increased clearance of OxLDL compared to IFN-γ-activated (M1) macrophages in vitro. Importantly, deficiency of IL-13 results in accelerated atherosclerosis in LDLR(-/-) mice without affecting plasma cholesterol levels. Thus, IL-13 protects from atherosclerosis and promotes a favourable plaque morphology, in part through the induction of alternatively activated macrophages.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Low levels of IL-13 contributed to the reduced ABCA1 expression in FXS astrocytes.
“It is possible that low levels of IL-13 contributed to the reduced ABCA1 expression in FXS astrocytes35.”
From An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis (2023) · cites this paper as [35]
The Results section reports higher ABCA1 expression in IL-13-stimulated macrophage foam cells and in lesions of IL-13-treated mice (Fig. 5C–F). That supports the proposed IL-13–ABCA1 link, but the paper does not establish that low IL-13 contributes to reduced ABCA1 expression in FXS astrocytes. (LLM, conf=0.84)
Experimental — accuracy not yet measuredReduced ABCA1 expression associated with reduced secretion of IL-13 and IL-10, which are implicated in ABCA1 regulation.
“Reduced ABCA1 expression associated with reduced secretion of IL-13 and IL-10, which are implicated in ABCA1 regulation (Cardilo-Reis et al., 2012; Ma et al., 2012).”
From Astrocytes in fragile X syndrome (2024) · cites this paper as Cardilo-Reis et al., 2012
The Results (pages not supplied) show that IL-13 stimulation increased ABCA1 expression in macrophage foam cells, while IL-13-deficient mice had reduced splenocyte production of IL-13 and IL-10. They do not establish that reduced ABCA1 expression was associated with those reductions in cytokine secretion, or that IL-10 regulates ABCA1. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe low level of IL-13 (54.3% of control) could contribute to the reduced ABCA1 expression in FXS astrocytes.
“Since there is evidence that IL-13 stimulates ABCA1 expression35, its low level (54.3% of control) could contribute to the reduced ABCA1 expression in FXS astrocytes.”
From An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis (2023) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works
Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495 · see citing works
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344 · see citing works
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197 · see citing works
The immune system in atherosclerosis
Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,331 · see citing works
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Grünig, G., Warnock, M. L., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M., et al. (1998) · Science · doi:10.1126/science.282.5397.2261 · Cited by 1,837 · see citing works
Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
Cybulsky, M. I., & Gimbrone, M. A. (1991) · Science · doi:10.1126/science.1990440 · Cited by 1,710 · see citing works
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Tedgui, A., & Mallat, Z. (2006) · Physiological Reviews · doi:10.1152/physrev.00024.2005 · Cited by 1,701 · see citing works
Delves, P. J., & Roitt, I. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007063430107 · Cited by 1,666 · see citing works
Acquisition of lymphokine-producing phenotype by CD4+ T cells
Seder, R. A., & Paul, W. E. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.003223 · Cited by 1,557 · see citing works
Bouhlel, M. A., Derudas, B., Rigamonti, E., Dièvart, R., Brozek, J., Haulon, S., Zawadzki, C., Jude, B., Torpier, G., Marx, N., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.010 · Cited by 1,325 · see citing works
Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
Cybulsky, M. I., Iiyama, K., Li, H., Zhu, S.-N., Chen, M., Iiyama, M., DAVIS, V. M., Gutierrez-Ramos, J.-C., Connelly, P. W., & Milstone, D. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11871 · Cited by 1,218 · see citing works
Fichtner‐Feigl, S., Strober, W., Kawakami, K., Puri, R. K., & Kitani, A. (2005) · Nature Medicine · doi:10.1038/nm1332 · Cited by 891 · see citing works
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.
Gupta, S. K. S., Pablo, A. M., Jiang, X., Wang, N., Tall, A. R., & Schindler, C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119465 · Cited by 863 · see citing works
Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
Huang, J. T., Welch, J. S., Ricote, M., Binder, C. J., Willson, T. M., Kelly, C., Witztum, J. L., Funk, C. D., Conrad, D. J., & Glass, C. K. (1999) · Nature · doi:10.1038/22572 · Cited by 854 · see citing works
Self-citationProtective Role of Interleukin-10 in Atherosclerosis
Mallat, Z., Besnard, S., Duriez, M., Deleuze, V., Emmanuel, F., Bureau, M. F., Soubrier, F., Esposito, B., Duez, H., Fiévet, C., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.8.e17 · Cited by 830 · see citing works
Combadière, C., Potteaux, S., Rodero, M., Simon, T., Pézard, A., Esposito, B., Merval, R., Proudfoot, A., Tedgui, A., & Mallat, Z. (2008) · Circulation · doi:10.1161/circulationaha.107.745091 · Cited by 714 · see citing works
Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis
Drechsler, M., Megens, R. T. A., van Zandvoort, M., Weber, C., & Soehnlein, O. (2010) · Circulation · doi:10.1161/circulationaha.110.961714 · Cited by 698 · see citing works
Self-citationRayner, K. J., Sheedy, F. J., Esau, C. C., Hussain, F. N., Temel, R. E., Parathath, S., van Gils, J. M., Rayner, A. J., Chang, A. N., Suarez, Y., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57275 · Cited by 690 · cited 1× · see citing works
“In this regard it is important to point out that Fisher and colleagues recently reported that regression of atherosclerotic lesions is associated with the up-regulation of markers of alternative macrophage activation (M2) (Feig et al, 2011a,b; Rayner et al, 2011).”
Innate and acquired immunity in atherogenesis
Binder, C. J., Chang, M.-K., Shaw, P. X., Miller, Y. I., Hartvigsen, K., Dewan, A. K., & Witztum, J. L. (2002) · Nature Medicine · doi:10.1038/nm1102-1218 · Cited by 642 · see citing works
Self-citationRecent Advances on the Role of Cytokines in Atherosclerosis
Ait‐Oufella, H., Taleb, S., Mallat, Z., & Tedgui, A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207415 · Cited by 578 · see citing works
Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System
LaPorte, S. L., Juo, Z. S., Václavíková, J., Colf, L. A., Qi, X., Heller, N. M., Keegan, A. D., & García, K. C. (2008) · Cell · doi:10.1016/j.cell.2007.12.030 · Cited by 519 · see citing works
Macrophage plasticity in experimental atherosclerosis
Khallou-Laschet, J., Varthaman, A., Fornasa, G., Compain, C., Gaston, A.-T., Clement, M., Dussiot, M., Levillain, O., Graff-Dubois, S., Nicoletti, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008852 · Cited by 517 · see citing works
Khan, B. V., Parthasarathy, S., Alexander, R. W., & Medford, R. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117776 · Cited by 463 · see citing works
Oxidized Low-Density Lipoprotein and Atherosclerosis
Steinberg, D. H., & Witztum, J. L. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179697 · Cited by 460 · see citing works
Binder, C. J., Hartvigsen, K., Chang, M.-K., Miller, M., Broide, D. H., Palinski, W., Curtiss, L. K., Corr, M., & Witztum, J. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20479 · Cited by 451 · see citing works
Self-citationDavenport, P., & Tipping, P. G. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63471-2 · Cited by 442 · see citing works
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity
Liang, H.-E., Reinhardt, R. L., Bando, J. K., Sullivan, B. M., Ho, I., & Locksley, R. M. (2011) · Nature Immunology · doi:10.1038/ni.2182 · Cited by 434 · see citing works
Interleukin-4 and Interleukin-13 Signaling Connections Maps
Kelly-Welch, A. E., Hanson, E. M., Boothby, M. R., & Keegan, A. D. (2003) · Science · doi:10.1126/science.1085458 · Cited by 417 · see citing works
IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells.
Bochner, B. S., Klunk, D. A., Sterbinsky, S. A., Coffman, R. L., & Schleimer, R. P. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.2.799 · Cited by 412 · see citing works
Interleukin-10 Blocks Atherosclerotic Events In Vitro and In Vivo
Oslund, L. J. P., Hedrick, C. C., Olvera, T., Hagenbaugh, A., Territo, M., Berliner, J. A., & Fyfe, A. I. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.12.2847 · Cited by 396 · see citing works
Interferon-γ elicits arteriosclerosis in the absence of leukocytes
Tellides, G., Tereb, D. A., Kirkiles-Smith, N. C., Kim, R. W., Wilson, J. H., Schechner, J. S., Lorber, M. I., & Pober, J. S. (2000) · Nature · doi:10.1038/35003221 · Cited by 391 · see citing works
Chinetti-Gbaguidi, G., Baron, M., Bouhlel, M. A., Vanhoutte, J., Copin, C., Sebti, Y., Derudas, B., Mayi, T., Bories, G., Tailleux, A., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.233775 · Cited by 387 · see citing works
A distinct role for interleukin-13 in Th2-cell-mediated immune responses
McKenzie, G. J., Bancroft, A. J., Grencis, R. K., & McKenzie, A. N. J. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70134-4 · Cited by 385 · see citing works
Impaired Development of Th2 Cells in IL-13-Deficient Mice
McKenzie, G. J., Emson, C. L., Bell, S. E., Anderson, S. M., Fallon, P. G., Zurawski, G., Murray, R., Grencis, R. K., & McKenzie, A. N. J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80625-1 · Cited by 381 · see citing works
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease
Swirski, F. K., Pittet, M. J., Kircher, M. F., Aikawa, E., Jaffer, F. A., Libby, P., & Weissleder, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604260103 · Cited by 367 · see citing works
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses
Buono, C., Binder, C. J., Stavrakis, G., Witztum, J. L., Glimcher, L. H., & Lichtman, A. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409015102 · Cited by 359 · see citing works
Self-citationMonocyte trafficking in acute and chronic inflammation
Ingersoll, M. A., Platt, A. M., Potteaux, S., & Randolph, G. J. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.001 · Cited by 348 · see citing works
Potteaux, S., Gautier, E. L., Hutchison, S. B., van Rooijen, N., Rader, D. J., Thomas, M. J., Sorci‐Thomas, M. G., & Randolph, G. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43802 · Cited by 335 · see citing works
Interleukin-4 and lnterleukin-13: Their Similarities and Discrepancies
Chomarat, P., & Banchereau, J. (1998) · International Reviews of Immunology · doi:10.3109/08830189809084486 · Cited by 331 · see citing works
Feig, J. E., Rong, J. X., Shamir, R., Sanson, M., Vengrenyuk, Y., Liu, J., Rayner, K. J., Moore, K. J., Garabedian, M. J., & Fisher, E. A. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016086108 · Cited by 313 · see citing works
Buono, C., Come, C. E., Stavrakis, G., Maguire, G. F., Connelly, P. W., & Lichtman, A. H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000059419.11002.6e · Cited by 288 · see citing works
A Critical Role for IL-13 in Resistance to Intestinal Nematode Infection
Bancroft, A. J., McKenzie, A. N. J., & Grencis, R. K. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3453 · Cited by 287 · see citing works
King, V. L., Szilvassy, S. J., & Daugherty, A. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0302.104905 · Cited by 265 · see citing works
Feig, J. E., Parathath, S., Rong, J. X., Mick, S. L., Vengrenyuk, Y., Grauer, L., Young, S. G., & Fisher, E. A. A. (2011) · Circulation · doi:10.1161/circulationaha.110.984146 · Cited by 236 · see citing works
Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts
Oriente, A., Fedarko, N. S., Pacocha, S. E., Huang, S.-K., Lichtenstein, L. M., & Essayan, D. M. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35380-7 · Cited by 230 · see citing works
Dansky, H. M., Barlow, C. B., Lominska, C. E., Sikes, J. L., Kao, C., Weinsaft, J. W., Cybulsky, M. I., & Smith, J. D. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.096625 · Cited by 219 · see citing works
Chiaramonte, M. G., Schopf, L. R., Neben, T. Y., Cheever, A. W., Donaldson, D. D., & Wynn, T. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.2.920 · Cited by 216 · see citing works
Gautier, E. L., Jakubzick, C., & Randolph, G. J. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.180505 · Cited by 216 · see citing works
Rong, J. X., Li, J., Reis, E. D., Choudhury, R. P., Dansky, H. M., Elmalem, V. I., Fallon, J. T., Breslow, J. L., & Fisher, E. A. A. (2001) · Circulation · doi:10.1161/hc4501.098952 · Cited by 204 · see citing works
Rapid regression of atherosclerosis: insights from the clinical and experimental literature
Williams, K. J., Feig, J. E., & Fisher, E. A. A. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1086 · Cited by 188 · see citing works
Insights into the initiation of type 2 immune responses
Oliphant, C. J., Barlow, J. L., & McKenzie, A. N. J. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03499.x · Cited by 172 · see citing works
Kumar, R. K., Herbert, C. A., Yang, M., Koskinen, A. M. L., McKenzie, A. N. J., & Foster, P. S. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2002.01420.x · Cited by 169 · see citing works
Kuperman, D. A., & Schleimer, R. P. (2008) · Current Molecular Medicine · doi:10.2174/156652408785161032 · Cited by 153 · see citing works
King, V. L., Cassis, L. A., & Daugherty, A. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060857 · Cited by 134 · see citing works
Woltmann, G., McNulty, C. A., Dewson, G., Symon, F. A., & Wardlaw, A. J. (2000) · Blood · doi:10.1182/blood.v95.10.3146 · Cited by 132 · see citing works
Panousis, C. G., & Zuckerman, S. H. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1565 · Cited by 131 · see citing works
Reis, E. D., Li, J., Fayad, Z. A., Rong, J. X., Hansoty, D. K., Aguinaldo, J.-G., Fallon, J. T., & Fisher, E. A. A. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.115963 · Cited by 129 · see citing works
Peters, W., & Charo, I. F. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00011 · Cited by 122 · see citing works
Feig, J. E., Vengrenyuk, Y., Reiser, V., Wu, C., Statnikov, A., Aliferis, C. F., Garabedian, M. J., Fisher, E. A., & Puig, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039790 · Cited by 118 · see citing works
Hadri, K. E., Mahmood, D. F. D., Couchie, D., Jguirim-Souissi, I., Genze, F., Diderot, V., Syrovets, T., Lunov, O., Simmet, T., & Rouis, M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.249334 · Cited by 115 · see citing works
IL‐13 induces expression of CD36 in human monocytes through PPARγ activation
Berry, A., Balard, P., Coste, A., Olagnier, D. P., Lagane, C., Authier, H., Benoit‐Vical, F., Lepert, J., Séguéla, J. P., Magnaval, J., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200636625 · Cited by 83 · see citing works
Nuocytes: expanding the innate cell repertoire in type-2 immunity
Barlow, J. L., & McKenzie, A. N. J. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0311160 · Cited by 69 · see citing works
Macrophage Heterogeneity: Relevance and Functional Implications in Atherosclerosis
Stöger, J. L., Goossens, P., & de Winther, M. P. J. (2010) · Current Vascular Pharmacology · doi:10.2174/157016110790886983 · Cited by 54 · see citing works
Engel, D. A., Beckers, L., Wijnands, E., Seijkens, T. T. P., Lievens, D., Drechsler, M. D., Gerdes, N., Soehnlein, O., Daemen, M. J. A. P., Stan, R. V., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-183350 · Cited by 49 · see citing works
Self-citationRey, A., M’Rini, C., Sozzani, P., Lamboeuf, Y., Béraud, M., Caput, D., Ferrara, P., & Pipy, B. (1998) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(98)00080-0 · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Macrophages in atherosclerosis: a dynamic balance
Moore, K. J., Sheedy, F. J., & Fisher, E. A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3520 · Cited by 2,559 · see citing works
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Huang, S. C., Everts, B., Ivanova, Y., O’Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W. L., Love-Gregory, L. D., Lam, W. Y., O’Neill, C. M., et al. (2014) · Nature Immunology · doi:10.1038/ni.2956 · Cited by 1,215 · see citing works
Macrophage Phenotype and Function in Different Stages of Atherosclerosis
Tabas, I., & Bornfeldt, K. E. (2016) · Circulation Research · doi:10.1161/circresaha.115.306256 · Cited by 1,121 · see citing works
The immunology of atherosclerosis
Gisterå, A., & Hansson, G. K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.51 · Cited by 982 · see citing works
T cell subsets and functions in atherosclerosis
Saigusa, R., Winkels, H., & Ley, K. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0352-5 · Cited by 742 · see citing works
Macrophages in Atherosclerosis Regression
Barrett, T. J. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312802 · Cited by 633 · see citing works
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Roy, P., Orecchioni, M., & Ley, K. F. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00584-1 · Cited by 584 · see citing works
Regulation of macrophage immunometabolism in atherosclerosis
Koelwyn, G. J., Corr, E. M., Erbay, E., & Moore, K. J. (2018) · Nature Immunology · doi:10.1038/s41590-018-0113-3 · Cited by 557 · see citing works
Inflammation and its Resolution as Determinants of Acute Coronary Syndromes
Libby, P., Tabas, I. A., Fredman, G., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302699 · Cited by 523 · see citing works
Inflammatory processes in cardiovascular disease: a route to targeted therapies
Ruparelia, N., Chai, J. T., Fisher, E. A., & Choudhury, R. P. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.185 · Cited by 477 · see citing works
Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Ramji, D. P., & Davies, T. S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.04.003 · Cited by 469 · see citing works
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution
Proto, J. D., Doran, A. C., Gusarova, G., Yurdagul, A., Sozen, E., Subramanian, M., Islam, M. N., Rymond, C. C., Du, J., Hook, J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.015 · Cited by 441 · see citing works
Molecular Biology of Atherosclerosis
Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works
Tailoring Materials for Modulation of Macrophage Fate
Li, J., Jiang, X., Li, H., Gelinsky, M., & Gu, Z. (2021) · Advanced Materials · doi:10.1002/adma.202004172 · Cited by 402 · see citing works
Ouimet, M., Ediriweera, H. N., Gundra, U. M., Sheedy, F. J., Ramkhelawon, B., Hutchison, S. B., Rinehold, K., van Solingen, C., Fullerton, M. D., Cecchini, K., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81676 · Cited by 394 · see citing works
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas
Zernecke, A., Winkels, H., Cochain, C., Williams, J. W., Wolf, D., Soehnlein, O., Robbins, C. S., Monaco, C. G., Park, I., McNamara, C. A., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316903 · Cited by 373 · see citing works
Self-citationMacrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
Chen, R., Zhang, H., Tang, B., Luo, Y., Yang, Y., Zhong, X., Chen, S., Xu, X., Huang, S., & Liu, C. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01840-1 · Cited by 387 · see citing works
Erratum: Inflammatory processes in cardiovascular disease: a route to targeted therapies
Ruparelia, N., Chai, J. T., Fisher, E. A. A., & Choudhury, R. P. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.33 · Cited by 363 · see citing works
Rahman, K., Vengrenyuk, Y., Ramsey, S., Vila, N. R., Girgis, N., Liu, J.-H., Gusarova, V., Gromada, J., Weinstock, A., Moore, K., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci75005 · Cited by 311 · see citing works
Atherosclerotic Plaque Destabilization
Silvestre-Roig, C., de Winther, M. P. J., Weber, C., Daemen, M. J. A. P., Lutgens, E., & Soehnlein, O. (2014) · Circulation Research · doi:10.1161/circresaha.114.302355 · Cited by 334 · see citing works
Self-citationThe role of cytokines in the development of atherosclerosis
Fatkhullina, A. R., Peshkova, I. O., & Koltsova, E. K. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916110134 · Cited by 322 · see citing works
Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
Geeraerts, X., Bolli, E., Fendt, S., & Ginderachter, J. A. V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00289 · Cited by 315 · see citing works
Inflammation and immune system interactions in atherosclerosis
Legein, B., Temmerman, L., Biessen, E. A. L., & Lutgens, E. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1289-1 · Cited by 292 · see citing works
Chen, L., Yang, W., Guo, Y., Chen, W., Zheng, P., Zeng, J., & Wu-song, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185406 · Cited by 273 · see citing works
Njock, M., Cheng, H. S., Dang, L. T. H., Nazari-Jahantigh, M., Lau, A. C., Boudreau, É., Roufaiel, M., Cybulsky, M. I., Schober, A., & Fish, J. E. (2015) · Blood · doi:10.1182/blood-2014-11-611046 · Cited by 270 · see citing works
Adaptive Response of T and B Cells in Atherosclerosis
Ketelhuth, D. F. J., & Hansson, G. K. (2016) · Circulation Research · doi:10.1161/circresaha.115.306427 · Cited by 269 · see citing works
Schaftenaar, F. H., Frodermann, V., Kuiper, J., & Lutgens, E. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000302 · Cited by 268 · see citing works
Atherosclerosis – A matter of unresolved inflammation
Viola, J. R., & Soehnlein, O. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.013 · Cited by 227 · see citing works
Self-citationMacrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis
Moore, K. J., Koplev, S., Fisher, E. A. A., Tabas, I. A., Björkegren, J., Doran, A. C., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2147 · Cited by 221 · see citing works
Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression
Peled, M., & Fisher, E. A. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00579 · Cited by 203 · see citing works
Adaptive (T and B Cells) Immunity and Control by Dendritic Cells in Atherosclerosis
Ait‐Oufella, H., Sage, A. P., Mallat, Z., & Tedgui, A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302761 · Cited by 201 · see citing works
Adaptive immunity in atherogenesis: new insights and therapeutic approaches
Lichtman, A. H., Binder, C. J., Tsimikas, S., & Witztum, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci63108 · Cited by 198 · see citing works
Self-citationJin, X., Yao, T., Zhou, Z., Zhu, J., Zhang, S., Hu, W., & Shen, C. (2015) · BioMed Research International · doi:10.1155/2015/732450 · Cited by 173 · see citing works
Metabolic influence on macrophage polarization and pathogenesis
Thapa, B., & Lee, K. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.6.140 · Cited by 173 · see citing works
Sex Differences in Inflammation during Atherosclerosis
Fairweather, D. (2014) · Clinical Medicine Insights Cardiology · doi:10.4137/cmc.s17068 · Cited by 172 · see citing works
High-Density Lipoprotein and Atherosclerosis Regression
Feig, J. E., Hewing, B., Smith, J. D., Hazen, S. L., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.300760 · Cited by 169 · see citing works
Macrophages in vascular inflammation and atherosclerosis
Cochain, C., & Zernecke, A. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1941-y · Cited by 164 · see citing works
Macrophage Plasticity and Atherosclerosis Therapy
Lin, P. C., Ji, H., Li, Y., & Guo, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.679797 · Cited by 166 · see citing works
Somatic Mutations and Clonal Hematopoiesis
Fuster, J. J., & Walsh, K. (2018) · Circulation Research · doi:10.1161/circresaha.117.312115 · Cited by 163 · see citing works
The Role of Macrophages in the Pathogenesis of Atherosclerosis
Blagov, A. V., Markin, A. M., Bogatyreva, A. I., Tolstik, T. V., Sukhorukov, V. N., & Orekhov, A. N. (2023) · Cells · doi:10.3390/cells12040522 · Cited by 161 · see citing works
He, T.-B., Huang, Y., Yang, L., Liu, T., Gong, W., Wang, X., Sheng, J., & Hu, J. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.11.038 · Cited by 157 · see citing works
M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment
Bi, Y., Chen, J., Hu, F., Liu, J., Li, M., & Zhao, L. (2019) · Neural Plasticity · doi:10.1155/2019/6724903 · Cited by 153 · see citing works
Immunobiology of Atherosclerosis: A Complex Net of Interactions
Herrero‐Fernández, B., Gómez-Bris, R., Somovilla-Crespo, B., & González, J. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215293 · Cited by 152 · see citing works
Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice
MacKinnon, A. C., Liu, X., Hadoke, P. W. F., Miller, M. R., Newby, D. E., & Sethi, T. (2013) · Glycobiology · doi:10.1093/glycob/cwt006 · Cited by 147 · see citing works
Cochain, C., Koch, M., Chaudhari, S. M., Busch, M., Pelisek, J., Boon, L., & Zernecke, A. (2015) · Circulation Research · doi:10.1161/circresaha.117.304611 · Cited by 139 · see citing works
He, S., Wu, C., Xiao, J., Li, D., Sun, Z., & Li, M. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12648 · Cited by 133 · see citing works
Kołosowska, N., Keuters, M. H., Wojciechowski, S., Keksa-Goldsteine, V., Laine, M. T., Malm, T., Goldsteins, G., Koıstınaho, J., & Dhungana, H. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00761-0 · Cited by 133 · see citing works
Freemerman, A. J., Zhao, L., Pingili, A. K., Teng, B., Cozzo, A. J., Fuller, A. M., Johnson, A., Milner, J. J., Lim, M. F., Galanko, J. A., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800002 · Cited by 132 · see citing works
Conflicting vascular and metabolic impact of the IL-33/sST2 axis
Altara, R., Ghali, R., Mallat, Z., Cataliotti, A., Booz, G. W., & Zouein, F. A. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy166 · Cited by 132 · see citing works
Inflammation: A Novel Therapeutic Target/Direction in Atherosclerosis
Li, B., Li, W., Li, X., & Zhou, H. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612822666161230142931 · Cited by 130 · see citing works
Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential
Spitz, C., Winkels, H., Bürger, C., Weber, C., Lutgens, E., Hansson, G. K., & Gerdes, N. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2080-2 · Cited by 130 · see citing works
Self-citationCytokines: Roles in Atherosclerosis Disease Progression and Potential Therapeutic Targets
Moss, J. W. E., & Ramji, D. P. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0072 · Cited by 126 · see citing works
Dykstra, J. A., Facile, T. R., Patrick, R. J., Francis, K. R., Milanovich, S. J., Weimer, J. M., & Kota, D. J. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0337 · Cited by 124 · see citing works
Cochain, C., Chaudhari, S. M., Koch, M., Wiendl, H., Eckstein, H., & Zernecke, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093280 · Cited by 119 · see citing works
Type-2 innate lymphoid cells control the development of atherosclerosis in mice
Newland, S. A., Mohanta, S. K., Clément, M., Taleb, S., Walker, J. A., Nus, M., Sage, A. P., Yin, C., Hu, D., Kitt, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15781 · Cited by 119 · see citing works
Self-citationSanson, M., Distel, E., & Fisher, E. A. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074676 · Cited by 112 · see citing works
Roles of Macrophages in Atherogenesis
Farahi, L., Sinha, S. K., & Lusis, A. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.785220 · Cited by 112 · see citing works
Malondialdehyde Epitopes as Targets of Immunity and the Implications for Atherosclerosis
Papac-Miličević, N., Busch, C. J., & Binder, C. J. (2016) · Advances in immunology · doi:10.1016/bs.ai.2016.02.001 · Cited by 109 · see citing works
Self-citationGinsenoside Rb1 enhances atherosclerotic plaque stability by skewing macrophages to the M2 phenotype
Zhang, X., Liu, M., Qiao, L., Zhang, X., Liu, X., Dong, M., Dai, H., Ni, M., Luan, X., Guan, J., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13329 · Cited by 107 · see citing works
Anti-atherosclerotic therapies: Milestones, challenges, and emerging innovations
Hetherington, I., & Totary-Jain, H. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.08.024 · Cited by 116 · see citing works
Scott, T., Lewis, C., Zhu, M., Wang, C., Samuel, C. S., Drummond, G. R., & Kemp‐Harper, B. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-46237-2 · Cited by 106 · see citing works
Ding, Y., Qian, L.-Y., Pang, J., Lin, J., Xu, Q., Wang, L., Huang, D., & Zou, H. (2017) · Oncotarget · doi:10.18632/oncotarget.18346 · Cited by 103 · see citing works
Atherosclerosis: orchestrating cells and biomolecules involved in its activation and inhibition
Munjal, A. K., & Khandia, R. (2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.11.002 · Cited by 100 · see citing works
Kang, H., Kim, S., Wong, D. S. H., Jung, H. J., Lin, S., Zou, K., Li, R., Li, G., Dravid, V. P., & Bian, L. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03405 · Cited by 94 · see citing works
Cytokines and MicroRNA in Coronary Artery Disease
Mirzaei, H., Ferns, G. A., Avan, A., & Mobarhan, M. G. (2017) · Advances in clinical chemistry · doi:10.1016/bs.acc.2017.06.004 · Cited by 91 · see citing works
Lymphocyte Migration Into Atherosclerotic Plaque
Li, J., & Ley, K. F. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303227 · Cited by 85 · see citing works
The Impact of Cytokines in Coronary Atherosclerotic Plaque: Current Therapeutic Approaches
Tsioufis, P., Theofilis, P., Tsioufis, K. P., & Tousoulis, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415937 · Cited by 84 · see citing works
Cobo, I., Tanaka, T. N., Glass, C. K., & Yeang, C. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000688 · Cited by 84 · see citing works
Yoshihara, T., Shimada, K., Fukao, K., Sai, E., Sato-Okabayashi, Y., Matsumori, R., Shiozawa, T., Shahi, H. A., Miyazaki, T., Tada, N., et al. (2015) · Circulation Journal · doi:10.1253/circj.cj-14-0471 · Cited by 80 · see citing works
Braddock, M., Hanania, N. A., Sharafkhaneh, A., Colice, G., & Carlsson, M. (2018) · Drug Safety · doi:10.1007/s40264-017-0636-9 · Cited by 78 · see citing works
miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages
Nguyen, M.-A., Hoang, H., Rasheed, A., Duchez, A., Wyatt, H., Cottee, M. L., Graber, T. E., Susser, L., Robichaud, S., Berber, I., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.319120 · Cited by 76 · see citing works
Hristodorov, D., Mladenov, R., von Felbert, V., Huhn, M., Fischer, R., Barth, S., & Thepen, T. (2015) · mAbs · doi:10.1080/19420862.2015.1066950 · Cited by 67 · see citing works
Gruber, S., Hendrikx, T., Tsiantoulas, D., Ozsvár-Kozma, M., Göderle, L., Mallat, Z., Witztum, J. L., Shiri‐Sverdlov, R., Nitschke, L., & Binder, C. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.027 · Cited by 75 · see citing works
Self-citationAziz, M., Cui, K., Das, M., Brown, K. E., Ardell, C. L., Febbraio, M., Pluskota, E., Han, J., Wu, H., Ballantyne, C. M., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602175 · Cited by 71 · see citing works
Discovering Inflammation in Atherosclerosis: Insights from Pathogenic Pathways to Clinical Practice
Madaudo, C., Coppola, G., Parlati, A. L. M., & Corrado, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116016 · Cited by 70 · see citing works
Innate and adaptive immunity in atherosclerosis
Miteva, K., Madonna, R., Caterina, R. D., & Linthout, S. V. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.04.006 · Cited by 70 · see citing works
Winkels, H., & Wolf, D. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.312137 · Cited by 69 · see citing works
Kusters, D. H. M., Chatrou, M. L. L., Willems, B. A. G., Saint‐Hubert, M. D., Bauwens, M., van der Vorst, E. P. C., Bena, S., Biessen, E. A. L., Perretti, M., Schurgers, L. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130484 · Cited by 70 · see citing works
Immunomodulation Strategies for the Successful Regeneration of a Tissue‐Engineered Vascular Graft
Zhang, F., & King, M. W. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200045 · Cited by 67 · see citing works
Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.05.010 · Cited by 65 · see citing works
Macrophage Plasticity and Function in the Eye and Heart
Wang, Z., Koenig, A. L., Lavine, K. J., & Apte, R. S. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.07.002 · Cited by 63 · see citing works
Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice
Babaev, V. R., Hebron, K. E., Wiese, C. B., Toth, C. L., Ding, L., Zhang, Y., May, J. M., Fazio, S., Vickers, K. C., & Linton, M. F. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m050633 · Cited by 63 · see citing works
MicroRNA regulation of macrophages in human pathologies
Wei, Y., & Schober, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2254-6 · Cited by 63 · see citing works
Marco, E. D., Gray, S. P., & Jandeleit-Dahm, K. A. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00068 · Cited by 62 · see citing works
Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis
Rojas, J., Salazar, J. J., Martínez, M. S., Palmar, J., Bautista, J., Chávez-Castillo, M., Gómez, A., & Bermúdez, V. (2015) · Scientifica · doi:10.1155/2015/851252 · Cited by 63 · see citing works
The why and how of adaptive immune responses in ischemic cardiovascular disease
Mallat, Z., & Binder, C. J. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00049-1 · Cited by 61 · see citing works
Self-citationImmune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis
Foks, A. C., & Kuiper, J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13802 · Cited by 59 · see citing works
Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis
Weinstock, A., Rahman, K., Yaacov, O., Nishi, H., Menon, P., Nikain, C. A., Garabedian, M. L., Pena, S., Akbar, N., Sansbury, B. E., et al. (2021) · eLife · doi:10.7554/elife.67932 · Cited by 57 · see citing works
The impact of type 2 immunity and allergic diseases in atherosclerosis
Fernández‐Gallego, N., Castillo‐González, R., Méndez‐Barbero, N., López‐Sanz, C., Obeso, D., Villaseñor, A., Escribese, M. M., López‐Melgar, B., Salamanca, J., Benedicto‐Buendía, A., et al. (2022) · Allergy · doi:10.1111/all.15426 · Cited by 59 · see citing works
Regression of Atherosclerosis: The Journey From the Liver to the Plaque and Back.
Fisher, E. (2016) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.301926 · Cited by 55 · see citing works
Serum Biomarkers in Head and Neck Squamous Cell Cancer
Kaskas, N. M., Moore‐Medlin, T., McClure, G. B., Ekshyyan, O. Y., Vanchiere, J. A., & Nathan, C. O. (2014) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2013.5688 · Cited by 55 · see citing works
Nagenborg, J., Goossens, P., Biessen, E. A. L., & Donners, M. M. P. C. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.10.005 · Cited by 50 · see citing works
T Cells in Atherosclerosis: Key Players in the Pathogenesis of Vascular Disease
Hinkley, H., Counts, D. A., VonCanon, E., & Lacy, M. (2023) · Cells · doi:10.3390/cells12172152 · Cited by 53 · see citing works
Tan, J., Liang, Y., Zhou, Y., He, Q., Tong, J., Deng, Y., Guo, W., Liang, K., Tang, J., Shi, W., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.318974 · Cited by 55 · see citing works
I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis
von Moltke, J., & Locksley, R. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.09.009 · Cited by 57 · see citing works
Darkhal, P., Gao, M., Ma, Y., & Liu, D. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.52 · Cited by 53 · see citing works
Immune-mediated mechanisms of atherosclerosis and implications for the clinic
Nus, M., & Mallat, Z. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1195686 · Cited by 44 · see citing works
Mechanistic Insight into PPARγ and Tregs in Atherosclerotic Immune Inflammation
Gao, Z., Xu, X.-R., Li, Y., Sun, K.-H., Yang, M.-F., Zhang, Q., Wang, S., Lin, Y., Lou, L., Wu, A., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.750078 · Cited by 52 · see citing works
Macrophages and T cells in atherosclerosis: a translational perspective
Bartlett, B., Ludewick, H. P., Misra, A., Lee, S., & Dwivedi, G. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00206.2019 · Cited by 54 · see citing works
- Authors
- Cardilo‐Reis, L., Gruber, S., Schreier, S. M., Drechsler, M., Papac‐Milicevic, N., Weber, C., Wagner, O., Stangl, H., Soehnlein, O., & Binder, C. J.
- Affiliations
- Austrian Academy of Sciences (AT)
- University of Vienna (AT)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Binder, Christoph J.
- Venue
- EMBO Molecular Medicine
- Published
- 2012-10-01
- Volume
- 4
- Issue
- 10
- Pages
- 1072-1086
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC3491837
- OpenAlex
- W2169929180
- Cited by
- 292
- References
- 68
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 21 · 2023: 21 · 2022: 32 · 2021: 21 · 2020: 16 · 2019: 20 · 2018: 20 · 2017: 26 · 2016: 21 · 2015: 24 · 2014: 22 · 2013: 17
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- EMBO Molecular Medicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Funded Access
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- IL-13, atherosclerosis, plaque composition, macrophage polarization, M2 macrophages, M1 macrophages, Th2 cytokines, VCAM-1, monocyte recruitment, collagen deposition, Ldlr-deficient mice, atherosclerotic plaque morphology
- MeSH terms
- Animals, Cholesterol, Disease Models, Animal, Female, Lipoproteins, LDL, Macrophage Activation, Macrophages, Male, Interleukin-13, Atherosclerosis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
