Rhythms of Mammalian Body Temperature Can Sustain Peripheral Circadian Clocks
Open accessAbstract
Background Low-amplitude temperature oscillations can entrain the phase of circadian rhythms in several unicellular and multicellular organisms, including Neurospora and Drosophila. Because mammalian body temperature is subject to circadian variations of 1 degrees C-4 degrees C, we wished to determine whether these temperature cycles could serve as a Zeitgeber for circadian gene expression in peripheral cell types.Results In RAT1 fibroblasts cultured in vitro, circadian gene expression could be established by a square wave temperature rhythm with a (Delta)T of 4 degrees C (12 hr 37 degrees C/12 hr 33 degrees C). To examine whether natural body temperature rhythms can also affect circadian gene expression, we first measured core body temperature cycles in the peritoneal cavities of mice by radiotelemetry. We then reproduced these rhythms with high precision in the liquid medium of cultured fibroblasts for several days by means of a homemade computer-driven incubator. While these "in vivo" temperature rhythms were incapable of establishing circadian gene expression de novo, they could maintain previously induced rhythms for multiple days; by contrast, the rhythms of control cells kept at constant temperature rapidly dampened. Moreover, circadian oscillations of environmental temperature could reentrain circadian clocks in the livers of mice, probably via the changes they imposed upon both body temperature and feeding behavior. Interestingly, these changes in ambient temperature did not affect the phase of the central circadian pacemaker in the suprachiasmatic nucleus (SCN) of the hypothalamus.Conclusions We postulate that both endogenous and environmental temperature cycles can participate in the synchronization of peripheral clocks in mammals.
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Peripheral oscillators, including those in the brain such as the cerebral cortex, can be entrained by ambient temperature cycles.
“evidence has accumulated over the last decade to indicate that peripheral oscillators, including those in the brain (e.g., cerebral cortex), can be entrained by ambient temperature cycles [8, 9, 28].”
From Sleep, vigilance, and thermosensitivity (2012) · cites this paper as [8]
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- Authors
- Brown, S. A., Zumbrunn, G., Fleury-Olela, F., Preitner, N., & Schibler, U.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Schibler, Ueli
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 12
- Issue
- 18
- Pages
- 1574-1583
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2171909239
- Cited by
- 589
- References
- 40
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 23 · 2023: 40 · 2022: 24 · 2021: 45 · 2020: 31 · 2019: 26 · 2018: 21 · 2017: 31 · 2016: 30 · 2015: 28 · 2014: 26 · 2013: 39 · 2012: 24
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
- Keywords
- peripheral circadian clock, circadian gene expression, temperature entrainment, zeitgebers, feeding behavior, suprachiasmatic nucleus, core body temperature, fibroblasts, constant temperature
- MeSH terms
- Animals, Body Temperature, Cell Line, Circadian Rhythm, DNA-Binding Proteins, Fibroblasts, Liver, Mice, Inbred BALB C, Models, Biological, Suprachiasmatic Nucleus, Transcription Factors, Gene Expression, Mice, Rats
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