The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children
Open accessAbstract
High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recent high-throughput sequencing analyses indicates that disturbances in composition and diversity of gut microbiome are associated with various disease conditions. However, microbiome-level studies on autism are limited and mostly focused on pathogenic bacteria. Therefore, here we aimed to define systemic changes in gut microbiome associated with autism and autism-related GI problems. We recruited 20 neurotypical and 20 autistic children accompanied by a survey of both autistic severity and GI symptoms. By pyrosequencing the V2/V3 regions in bacterial 16S rDNA from fecal DNA samples, we compared gut microbiomes of GI symptom-free neurotypical children with those of autistic children mostly presenting GI symptoms. Unexpectedly, the presence of autistic symptoms, rather than the severity of GI symptoms, was associated with less diverse gut microbiomes. Further, rigorous statistical tests with multiple testing corrections showed significantly lower abundances of the genera Prevotella, Coprococcus, and unclassified Veillonellaceae in autistic samples. These are intriguingly versatile carbohydrate-degrading and/or fermenting bacteria, suggesting a potential influence of unusual diet patterns observed in autistic children. However, multivariate analyses showed that autism-related changes in both overall diversity and individual genus abundances were correlated with the presence of autistic symptoms but not with their diet patterns. Taken together, autism and accompanying GI symptoms were characterized by distinct and less diverse gut microbial compositions with lower levels of Prevotella, Coprococcus, and unclassified Veillonellaceae.
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In the citing paper
“Cross-sectional studies comparing the gut microbiota composition between healthy and ASD individuals have revealed an altered microbiota profile in patients with ASD, with several studies reporting increased levels of Clostridium and Lactobacillus along with elevated levels of SCFAs, including propionic and butyric acid (Wang et al., 2012, 2013; De Angelis et al., 2013; Kang et al., 2013).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Kang et al., 2013
In the citing paper
“Nevertheless, reduced bacterial diversity and increased biomass were reported in individuals with ASD [228,230].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“The most important may be reduced amounts of Prevotella, Corprococcus, and Veilonellaceae (participating in carbohydrate ingestion and fermentation), Bacteroidetes, Actinobacteria, Proteobacteria [228]”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“In the case of impaired BBB, which can be observed in certain (but not all) autistic subjects [37,254], LPS or SCFAs may cause brain inflammation and thus, further facilitate access to the brain for harmful substances, like heavy metals, that can accumulate there [228,246,255].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“The last three studies indicated decreases; however, the studies came from one laboratory [39–41].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“Instead, these seven studies showed either a non-significant result in relative abundance [41, 48, 50, 52] or a lower relative abundance in children classified as ASD versus SIB or HC [31, 39, 42].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“No specific findings were identified in the Verrucomicrobia phylum [31, 33, 36, 39, 48] and in the Verrucomicrobiaceae family [31, 37, 39, 41, 52].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“This study did not replicate previously reported differences in the relative abundances of bacterial categories, including the Bacteroidetes phylum [12–14], the Sutterella genus [7,8,10] and the Prevotella genus [11] between ASD and unrelated control children.”
From Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection (2015) · cites this paper as [11]
In the citing paper
“Of note, previous studies [6–8,12,14], with the exception of one study [13], failed to detect differences in microbial composition between ASD and NT siblings [11].”
From Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection (2015) · cites this paper as [11]
In the citing paper
“Stool-based microbiome characterization in several cohorts identified specific genera that differed in ASD vs control subjects, but most previous studies conducted their analysis at higher taxonomic levels, with little published data at the genus or species (ie, OTU) level.22, 25, 26, 27”
From Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder (2017) · cites this paper as [25]
In the citing paper
“Stool-based microbiome characterization in several cohorts identified specific genera that differed in ASD vs control subjects, but most previous studies conducted their analysis at higher taxonomic levels, with little published data at the genus or species (ie, OTU) level.22, 25, 26, 27”
From Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder (2017) · cites this paper as [25]
In the citing paper
“Indeed, some studies have revealed significant reductions in the relative abundance of Prevotella, Coprococcus, Enterococcus, Lactobacillus, Streptococcus, Lactococcus, Staphylococcus, Ruminococcus, and Bifidobacterium species in children with ASD compared with healthy controls [36,128,143].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Several studies on ASD have showed changes in the composition of the microbiota, particularly in the relative abundance of the mains gut bacterial phyla [36,37,143,144].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“In the scientific literature, some studies highlight a higher abundance of Clostridia and Desulfovibrio bacteria and a lower ratio of Bacteroidetes to Firmicutes in ASD [37,39,143,145].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Others studies observed, in ASD children, high abundance of: Akkermansia muciniphilia, [36,143,148] Desulfovibrio, [37] and Faecalibacterium prausnitzii [36].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Of the nine studies compared α-diversity, three studies demonstrated that α-diversity has a significant reduction in ASD patients16,19,22.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Two sequencing studies reported that the abundance of Akkermansia was elevated in ASD patients22,23. Inconsistently, one qPCR study30 indicated that lower amount of Akkermansia muciniphila was found in feces of ASD patients than HCs.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Among them, three studies18,19,22 indicated the functional modules of gut microbiota in ASD patients were substantially different from that in HCs (Fig. 2).”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In two studies of Kang et al. (Figs. 2b, c)19,22, the pathways of “Cell Motility”, “Cellular Processes” and “Bacterial motility proteins” had consistent significant discriminative power in HCs. In addition, “Bacterial chemotaxis” and “Flagellar assembly” were also noted.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“It should be noted that pathways of “Huntingtons disease” and “Amyotrophic lateral sclerosis (ALS)” under Neurodegenerative Diseases category as well as “Glutamatergic synapse” under Nervous System category were also increased in ASD patients.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In ASD patients, the functional modules of metabolism were higher than that in HCs, such as “Oxidative phosphorylation” under Energy Metabolism category and “Glycine, serine and threonine metabolism” under Amino Acid Metabolism.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Whereas, in ASD patients, the most enhanced functional module of microbiota was metabolism, including amino acid metabolism, lipid metabolism, carbohydrate metabolism, energy metabolism, cofactors and vitamins metabolism and tetracycline biosynthesis.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Akkermansia and Ruminococcus are mucin-degrading bacterium and associated with the gut permeability59,60.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [59]
In the citing paper
“Moreover, some functional modules involved in neurodegenerative diseases in human, such as Huntington disease and ALS were also raised in ASD patients.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Functions of xenobiotics degradation such as toluene, aminobenzoate, polycyclic aromatic hydrocarbon, and bisphenol were also enhanced.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In two accordant studies19,22, functional modules of microbiota in HCs mostly involved in cell motility, cellular processes, bacterial motility proteins, bacterial chemotaxis, and flagellar assembly, which indicated the basic physiological maintenance under normal condition.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In addition, GI microbial dysbiosis, an imbalance in the organisms that make up the gut microbiota, has been documented in multiple studies of children with ASD [5, 7–14].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [13]
In the citing paper
“However, other studies have shown that Akkermansia levels are higher in children with ASD compared to typically developing children, although species-level composition was not examined [13].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [13]
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Citations
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Classification and Regression by randomForest
Liaw, A. I., & Wiener, M. C. (2007) · Cited by 18,594
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
Kaper, J. B., Nataro, J. P., & Mobley, H. L. T. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro818 · Cited by 5,583
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Conservation evaluation and phylogenetic diversity
Faith, D. (1992) · Biological Conservation · doi:10.1016/0006-3207(92)91201-3 · Cited by 5,495
The Ribosomal Database Project: improved alignments and new tools for rRNA analysis
Cole, J. R., Wang, Q., Cardenas, E., Fish, J., Chai, B., Farris, R. J., Kulam-Syed-Mohideen, A. S., McGarrell, D. M., Marsh, T. L., Garrity, G. M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn879 · Cited by 4,873
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR ampliconsPreprint
Haas, B. J., Gevers, D., Earl, A. M., Feldgarden, M., Ward, D. V., Giannoukos, G., Ciulla, D., Tabbaa, D., Highlander, S. K., Sodergren, E. J., et al. (2011) · Genome Research · doi:10.1101/gr.112730.110 · Cited by 3,527
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952
Dethlefsen, L., & Relman, D. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000087107 · Cited by 2,421
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361
Identification and Evaluation of Children With Autism Spectrum Disorders
Johnson, C. P., Myers, S. M., & and the Council on Children With Disabilities (2007) · Pediatrics · doi:10.1542/peds.2007-2361 · Cited by 2,011
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
Hallmayer, J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.76 · Cited by 1,970
Prevalence of Autism Spectrum Disorders in a Total Population Sample
Kim, Y. S., Leventhal, B. L., Koh, Y.-J., Fombonne, E., Laska, E., Lim, E.-C., Cheon, K.-A., Kim, S.-J., Kim, Y.-K., Lee, H., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10101532 · Cited by 1,524
The microbiology of butyrate formation in the human colon
Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S., & Flint, H. J. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11467.x · Cited by 1,320
The indigenous gastrointestinal microflora
Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153 · cited 1×
“Up to 10(14) bacteria in human intestine balance the immune system, help digestion, produce vitamins, and promote GI motility [5].”
BackgroundAdams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076
Self-citationStecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041
Pyrosequencing study of fecal microflora of autistic and control children
Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977
Xenobiotics shape the physiology and gene expression of the active human gut microbiome
Maurice, C. F., Haiser, H. J., & Turnbaugh, P. J. (2013) · Cell · doi:10.1016/j.cell.2012.10.052 · Cited by 811
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784
Shifting the balance: antibiotic effects on host–microbiota mutualism
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747
Duncan, S. H., Barcenilla, A., Stewart, C. S., Pryde, S. E., & Flint, H. J. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.10.5186-5190.2002 · Cited by 743
Sharp, W. G., Berry, R. C., McCracken, C., Nuhu, N. N., Marvel, E., Saulnier, C. A., Klin, A., Jones, W., & Jaquess, D. L. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1771-5 · Cited by 643
Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain
Simopoulos, A. P. (2011) · Molecular Neurobiology · doi:10.1007/s12035-010-8162-0 · Cited by 627
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612
Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children
Song, Y., Liu, C., & Finegold, S. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6459-6465.2004 · Cited by 556
Williams, B. L., Hornig, M., Buie, T., Bauman, M. L., Cho Paik, M., Wick, I., Bennett, A., Jabado, O., Hirschberg, D. L., & Lipkin, W. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024585 · Cited by 492
Gastrointestinal abnormalities in children with autistic disorder
Horváth, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C. B., & Tildón, J. T. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70052-1 · Cited by 489
Williams, B. L., Hornig, M., Parekh, T., & Lipkin, W. I. (2012) · mBio · doi:10.1128/mbio.00261-11 · Cited by 378
MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365
Dieterle, F., Perentes, E., Cordier, A., Roth, D. R., Verdes, P. S., Grenet, O., Pantano, S., Moulin, P., Wahl, D. R., Mahl, A., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1622 · Cited by 338
Preserving the Information Content of Species: Genetic Diversity, Phylogeny, and Conservation Worth
Crozier, R. H. (1997) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.ecolsys.28.1.243 · Cited by 319
Biomarkers in acute myocardial infarction
Chan, D., & Ng, L. L. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-34 · Cited by 297
Gut microbiota: Changes throughout the lifespan from infancy to elderly
O’Toole, P. W., & Claesson, M. J. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.11.010 · Cited by 287
Hooda, S., Boler, B. M. V., Serao, M. C. R., Brulc, J. M., Staeger, M. A., Boileau, T. W., Dowd, S. E., Fahey, G. C., & Swanson, K. S. (2012) · The Journal of Nutrition · doi:10.3945/jn.112.158766 · Cited by 272
Yap, I. K. S., Li, J. V., Saric, J., Martin, F., Davies, H., Wang, Y., Wilson, I. D., Nicholson, J. K., Utzinger, J., Marchesi, J. R., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr700864x · Cited by 235
Selmer, T., & Andrei, P. I. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02001.x · Cited by 214
Huws, S., Kim, E. J., Lee, M. R. F., Scott, M. B., Tweed, J. K. S., Pinloche, E., Wallace, R. J., & Scollan, N. D. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02452.x · Cited by 212
Mercury, lead, and zinc in baby teeth of children with autism versus controls
Adams, J. B., Romdalvik, J., Ramanujam, V. M. S., & Legator, M. S. (2007) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/15287390601172080 · Cited by 211
Self-citationDesulfovibrio species are potentially important in regressive autism
Finegold, S. M. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.04.032 · Cited by 197
Daly, K., PROUDMAN, C. J., Duncan, S. H., Flint, H. J., Dyer, J., & Shirazi‐Beechey, S. P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003825 · Cited by 194
Glutathione in blood of patients with Friedreich's ataxia
Piemonte, F., Pastore, A., Tozzi, G., Tagliacozzi, D., Santorelli, F. M., Carrozzo, R., Casali, C., Damiano, M. G., Federici, G., & Bertini, E. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00922.x · Cited by 174
Early medical history of children with autism spectrum disorders
NIEHUS, R., & LORD, C. (2006) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200604002-00010 · Cited by 152
Bifidobacterium exopolysaccharides fermented by human microbiota
Salazar, N., Fernández, M., Hernández-Barranco, A., Ruas-Madiedo, P., & Reyes-Gavilán, C. D. L. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00325-08 · Cited by 134
Hashizume, K., Tsukahara, T., Yamada, K., Koyama, H., & Ushida, K. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3187 · Cited by 130
Li, G., Park, S., Kang, D., Krajmalnik‐Brown, R., & Rittmann, B. E. (2011) · Environmental Science & Technology · doi:10.1021/es2016523 · Cited by 125
Self-citationSun, Y., Wolcott, R. D., & Dowd, S. E. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-089-8_9 · Cited by 104
Schneider, C. K., Melmed, R. D., Barstow, L. E., Enriquez, F. J., Ranger‐Moore, J., & Ostrem, J. A. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0141-y · Cited by 96
A permutation test for inference in logistic regression with small‐ and moderate‐sized data sets
Potter, D. M. (2004) · Statistics in Medicine · doi:10.1002/sim.1931 · Cited by 91
Altered glutathione homeostasis in animals prenatally exposed to lipopolysaccharide
ZHU, Y., CARVEY, P., & LING, Z. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2006.12.013 · Cited by 85
Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study.
Lonsdale, D., Shamberger, R. J., & AUDHYA, T. K. (2002) · PubMed · Cited by 85
Ziv‐El, M., Delgado, A. G., Yao, Y., Kang, D., Nelson, K. G., Halden, R. U., & Krajmalnik‐Brown, R. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3388-y · Cited by 68
Self-citationMercury in first-cut baby hair of children with autismversustypically-developing children
Adams, J. B., Romdalvik, J., Levine, K. E., & Hu, L.-W. (2008) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772240701699294 · Cited by 57
Self-citationComplete genome sequence of Veillonella parvula type strain (Te3T)
Gronow, S., Welnitz, S., Lapidus, A. L., Nolan, M., Ivanova, N., del Rio, T. G., Copeland, A., Chen, F., Tice, H. N., Pitluck, S., et al. (2010) · Standards in Genomic Sciences · doi:10.4056/sigs.521107 · Cited by 47
Minami, T., Oda, K., Gima, N., & Yamazaki, H. (2007) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2007.08.004 · Cited by 14
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1 of the 71 references couldn’t be matched to a known paper.
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The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible
McMurdie, P. J., & Holmes, S. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003531 · Cited by 3,034
Current understanding of the human microbiome
Gilbert, J. A., Blaser, M. J., Caporaso, J. G., Jansson, J. K., Lynch, S. V., & Knight, R. (2018) · Nature Medicine · doi:10.1038/nm.4517 · Cited by 2,609
Gut microbiota are related to Parkinson's disease and clinical phenotype
Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968
Metadata
- Authors
- Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R.
- Affiliations
- Arizona State University (US)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-07-03
- Volume
- 8
- Issue
- 7
- Pages
- e68322
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3700858
- OpenAlex
- W2149756110
- Cited by
- 976
- References
- 71
- Citations by year
- 2026: 36 · 2025: 75 · 2024: 65 · 2023: 94 · 2022: 83 · 2021: 114 · 2020: 85 · 2019: 100 · 2018: 94 · 2017: 53 · 2016: 74 · 2015: 49 · 2014: 39 · 2013: 14
- FWCI
- 26.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Arizona State University Library Digital Repository (Arizona State University) (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Autism Research Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- autism spectrum disorder, gut microbiota, gastrointestinal symptoms, Prevotella, Coprococcus, Veillonellaceae, microbial diversity, autism severity, diet patterns, fecal microbiota, children
- MeSH terms
- Adolescent, Autistic Disorder, Child, Child, Preschool, Female, Gastrointestinal Diseases, Humans, Male, Phylogeny, ROC Curve, Incidence, Cluster Analysis, Bacteroidaceae Infections, Prevotella, Gastrointestinal Tract, Biodiversity, Metagenome, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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