The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Availability of glucose becomes limited during various stress conditions, such as brain ageing.
“However, availability of glucose becomes limited during various stress conditions, such as brain ageing34–39.”
From Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel (2025) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366
The energetics of CNS white matter
Harris, J. J., & Attwell, D. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3430-11.2012 · Cited by 505
Minireview: translational animal models of human menopause: challenges and emerging opportunities
Diaz Brinton, R. (2012) · Endocrinology · doi:10.1210/en.2012-1340 · Cited by 272
Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex
CHENG, C. M., COHEN, M., WANG, J., & BONDY, C. A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0398com · Cited by 115
Flagged first, then by citations
Research works printed but not linked: 53
- J Nilsen, 2007, Estradiol in vivo regulation of brain mitochondrial proteome, The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 27, 14069, 10.1523/JNEUROSCI.4391-07.2007 · DOI
- J Yao, 2010, Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence, Biochimica et Biophysica Acta, 1800, 1121, 10.1016/j.bbagen.2010.06.002 · DOI
- Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, et al. (2011) Ovarian hormone loss induces bioenergetic deficits and mitochondrial beta-amyloid. Neurobiology of Aging. · DOI
- J Yao, 2009, Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease, Proceedings of the National Academy of Sciences of the United States of America, 106, 14670, 10.1073/pnas.0903563106 · DOI · Paper page
- NL Rasgon, 2005, Estrogen use and brain metabolic change in postmenopausal women, Neurobiology of Aging, 26, 229, 10.1016/j.neurobiolaging.2004.03.003 · DOI
- Weber MT, Maki PM, McDermott MP (2013) Cognition and mood in perimenopause: A systematic review and meta-analysis. J Steroid Biochem Mol Biol. [Epub ahead of print] · DOI
- MT Weber, 2013, Cognition in perimenopause: the effect of transition stage, Menopause, 20, 511, 10.1097/gme.0b013e31827655e5 · DOI
- S Hoyer, 1991, Abnormalities of glucose metabolism in Alzheimer's disease, Annals of the New York Academy of Sciences, 640, 53, 10.1111/j.1749-6632.1991.tb00190.x · DOI
- L Mosconi, 2005, Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD, European Journal of Nuclear Medicine and Molecular Imaging, 32, 486, 10.1007/s00259-005-1762-7 · DOI
- L Mosconi, 2009, FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease, European Journal of Nuclear Medicine and Molecular Imaging, 36, 811, 10.1007/s00259-008-1039-z · DOI · Paper page
- L Mosconi, 2006, Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease, Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 47, 1778
- EM Reiman, 2004, Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia, Proceedings of the National Academy of Sciences of the United States of America, 101, 284, 10.1073/pnas.2635903100 · DOI · Paper page
- L Mosconi, 2007, Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism, Proceedings of the National Academy of Sciences of the United States of America, 104, 19067, 10.1073/pnas.0705036104 · DOI · Paper page
- Brinton RD (2010) Neuroendocrinology of aging. In: Fillit H RK, Woodhouse K, eds, editor. Brocklehurst's Textbook of Geriatric Medicine and Gerontology. 7th edition ed. Philadelphia: Saunders Elsevier. pp. 163–169. · DOI
- CE Finch, 1984, Ovarian and steroidal influences on neuroendocrine aging processes in female rodents, Endocr Rev, 5, 467, 10.1210/edrv-5-4-467 · DOI
- TA Van Kempen, 2011, Accelerated ovarian failure: a novel, chemically induced animal model of menopause, Brain Research, 1379, 176, 10.1016/j.brainres.2010.12.064 · DOI
- JF Nelson, 1982, A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology, Biol Reprod, 27, 327, 10.1095/biolreprod27.2.327 · DOI
- RD Brinton, 2008, The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications, Trends in Neurosciences, 31, 529, 10.1016/j.tins.2008.07.003 · DOI
- J Nilsen, 2003, Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression, Proceedings of the National Academy of Sciences of the United States of America, 100, 2842, 10.1073/pnas.0438041100 · DOI
- SJ Vannucci, 1998, Glucose transporter expression in brain: relationship to cerebral glucose utilization, Developmental Neuroscience, 20, 369, 10.1159/000017333 · DOI
- IA Simpson, 2007, Supply and demand in cerebral energy metabolism: the role of nutrient transporters, Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 27, 1766, 10.1038/sj.jcbfm.9600521 · DOI · Paper page
- SU Devaskar, 1992, The mammalian glucose transporters, Pediatr Res, 31, 1, 10.1203/00006450-199201000-00001 · DOI
- EK Pauwels, 2000, Positron-emission tomography with [18F]fluorodeoxyglucose. Part I. Biochemical uptake mechanism and its implication for clinical studies, Journal of Cancer Research and Clinical Oncology, 126, 549, 10.1007/PL00008465 · DOI
- JE Wilson, 1995, Hexokinases, Reviews of Physiology, Biochemistry and Pharmacology, 126, 65, 10.1007/BFb0049776 · DOI
- LG Korotchkina, 2006, Characterization of testis-specific isoenzyme of human pyruvate dehydrogenase, The Journal of Biological Chemistry, 281, 9688, 10.1074/jbc.M511481200 · DOI
- L Pellerin, 2003, Lactate as a pivotal element in neuron-glia metabolic cooperation, Neurochemistry International, 43, 331, 10.1016/S0197-0186(03)00020-2 · DOI
- L Pellerin, 1998, Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain, Proceedings of the National Academy of Sciences of the United States of America, 95, 3990, 10.1073/pnas.95.7.3990 · DOI
- J Yao, 2011, Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions, Molecular Aspects of Medicine, 32, 247, 10.1016/j.mam.2011.10.005 · DOI
- K Pierre, 2005, Monocarboxylate transporters in the central nervous system: distribution, regulation and function, Journal of Neurochemistry, 94, 1, 10.1111/j.1471-4159.2005.03168.x · DOI · Paper page
- A Aubert, 2005, Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation, Proceedings of the National Academy of Sciences of the United States of America, 102, 16448, 10.1073/pnas.0505427102 · DOI
- P Fattoretti, 2001, Quantitative immunohistochemistry of glucose transport protein (Glut3) expression in the rat hippocampus during aging, J Histochem Cytochem, 49, 671, 10.1177/002215540104900518 · DOI · Paper page
- JM Ferreira, 2011, Activity-dependent regulation of surface glucose transporter-3, The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 31, 1991, 10.1523/JNEUROSCI.1850-09.2011 · DOI · Paper page
- SJ Vannucci, 2003, Developmental switch in brain nutrient transporter expression in the rat, Am J Physiol Endocrinol Metab, 285, E1127, 10.1152/ajpendo.00187.2003 · DOI
- S Yu, 1998, The 45 kDa form of glucose transporter 1 (GLUT1) is localized in oligodendrocyte and astrocyte but not in microglia in the rat brain, Brain Research, 797, 65, 10.1016/S0006-8993(98)00372-2 · DOI
- JE Rinholm, 2011, Regulation of oligodendrocyte development and myelination by glucose and lactate, J Neurosci, 31, 538, 10.1523/JNEUROSCI.3516-10.2011 · DOI · Paper page
- LI Sanchez-Abarca, 2001, Oligodendrocytes use lactate as a source of energy and as a precursor of lipids, Glia, 36, 321, 10.1002/glia.1119 · DOI · Paper page
- WB Rowe, 2007, Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats, J Neurosci, 27, 3098, 10.1523/JNEUROSCI.4163-06.2007 · DOI
- RN Kalaria, 1989, Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease, J Neurochem, 53, 1083, 10.1111/j.1471-4159.1989.tb07399.x · DOI · Paper page
- M Merlini, 2011, Vascular beta-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAbeta mice, Acta Neuropathol, 122, 293, 10.1007/s00401-011-0834-y · DOI · Paper page
- F Ding, 2013, Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's, PloS One, 8, e59825, 10.1371/journal.pone.0059825 · DOI
- L Leybaert, 2005, Neurobarrier coupling in the brain: a partner of neurovascular and neurometabolic coupling, J Cereb Blood Flow Metab, 25, 2, 10.1038/sj.jcbfm.9600001 · DOI
- H Lund-Andersen, 1979, Transport of glucose from blood to brain, Physiol Rev, 59, 305, 10.1152/physrev.1979.59.2.305 · DOI
- AA Qutub, 2005, Glucose transport to the brain: a systems model, Brain Res Brain Res Rev, 49, 595, 10.1016/j.brainresrev.2005.03.002 · DOI
- LM Saraiva, 2010, Amyloid-beta triggers the release of neuronal hexokinase 1 from mitochondria, PloS One, 5, e15230, 10.1371/journal.pone.0015230 · DOI · Paper page
- RA Hawkins, 1971, Ketone-body utilization by adult and suckling rat brain in vivo, The Biochemical Journal, 122, 13, 10.1042/bj1220013 · DOI
- ME Morris, 2008, Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid, AAPS J, 10, 311, 10.1208/s12248-008-9035-6 · DOI
- JL Chou, 2011, Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease, Journal of Proteomics, 74, 466, 10.1016/j.jprot.2010.12.012 · DOI
- J Edmond, 1987, Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture, J Neurosci Res, 18, 551, 10.1002/jnr.490180407 · DOI
- I Kadish, 2009, Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment, J Neurosci, 29, 1805, 10.1523/JNEUROSCI.4599-08.2009 · DOI
- RD Brinton, 2009, Estrogen-induced plasticity from cells to circuits: predictions for cognitive function, Trends Pharmacol Sci, 30, 212, 10.1016/j.tips.2008.12.006 · DOI
- K Moorthy, 2004, Effect of estradiol and progesterone treatment on carbohydrate metabolizing enzymes in tissues of aging female rats, Biogerontology, 5, 249, 10.1023/B:BGEN.0000038026.89337.02 · DOI
- A Del Sole, 2008, Individual cerebral metabolic deficits in Alzheimer's disease and amnestic mild cognitive impairment: an FDG PET study, Eur J Nucl Med Mol Imaging, 35, 1357, 10.1007/s00259-008-0773-6 · DOI
- L Mosconi, 2008, Hippocampal hypometabolism predicts cognitive decline from normal aging, Neurobiology of Aging, 29, 676, 10.1016/j.neurobiolaging.2006.12.008 · DOI · Paper page
Cited by
Sorted by citations
Understanding the impact of sex and gender in Alzheimer’s disease: A call to action
Nebel, R. A., Aggarwal, N. T., Barnes, L. L., Gallagher, A., Goldstein, J. M., Kantarci, K., Mallampalli, M. P., Mormino, E. C., Scott, L., Yu, W. H., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.04.008 · Cited by 839
Brain metabolism in health, aging, and neurodegeneration
Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752
Age, APOE and sex: triad of risk of Alzheimer’s disease.
Riedel, B. C., Thompson, P. M., & Brinton, R. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.012 · Cited by 627
Self-citationD’Amato, A., Di Cesare Mannelli, L., Lucarini, E., Man, A. L., Le Gall, G., Branca, J. J. V., Ghelardini, C., Amedei, A., Bertelli, E., Regoli, M., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00914-w · Cited by 269
Female Sex and Alzheimer's Risk: The Menopause Connection
Scheyer, O., Rahman, A., Hristov, H., Berkowitz, C., Isaacson, R. S., Diaz Brinton, R., & Mosconi, L. (2018) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2018.34 · Cited by 268
Wu, L., Zhang, X., & Zhao, L. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.2262-17.2018 · Cited by 185
Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine
Lynch, M. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.868448 · Cited by 146
Hernandez, A. R., Hernandez, C. M., Campos, K., Truckenbrod, L., Federico, Q., Moon, B., McQuail, J. A., Maurer, A. P., Bizon, J. L., & Burke, S. N. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00391 · Cited by 111
Pawlosky, R. J., Kemper, M. F., Kashiwaya, Y., King, M. T., Mattson, M. P., & Veech, R. L. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13958 · Cited by 108
Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity
Navakkode, S., & Kennedy, B. K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1428244 · Cited by 75
A New Hypothesis for Alzheimer’s Disease: The Lipid Invasion Model
Rudge, J. D. (2022) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-210299 · Cited by 58
Amoah, S. K. S., Dalla Vecchia, M. T., Pedrini, B., Carnhelutti, G. L., Gonçalves, A. E., dos Santos, D. A., Biavatti, M. W., & de Souza, M. M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.018 · Cited by 40
El Massry, M., Alaeddine, L. M., Ali, L., Saad, C., & Eid, A. A. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867327666200908114902 · Cited by 27
Greda, A. K., Gomes, J. P., Schmidt-Krueger, V., Zurawska-Plaksej, E., Fritsche-Guenther, R., Rudolph, I.-M., Telugu, N. S., Cömert, C., Kirwan, J., Kunz, S., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01389-5 · Cited by 21
Metadata
- Authors
- Ding, F., Yao, J., Rettberg, J. R., Chen, S., & Brinton, R. D.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-11-11
- Volume
- 8
- Issue
- 11
- Pages
- e79977
- ISSN
- 1932-6203
- PMC
- PMC3823655
- Cited by
- 262
- References
- 7
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review