Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
Open accessAbstract
Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether cognitively normal subjects with a parental family history of AD show cerebral metabolic rate of glucose (CMRglc) reductions consistent with AD as compared with those without a family history and whether there are parent gender effects. Forty-nine 50- to 80-year-old normal subjects were examined who received clinical, neuropsychological, and 2-[(18)F]fluoro-2-deoxy-d-glucose-positron emission tomography examinations, including 16 subjects with a maternal (FHm) and eight with a paternal (FHp) family history of AD and 25 with no family history (FH(-)). FH groups were comparable for demographic and neuropsychological measures. As compared with both FH(-) and FHp groups, FHm subjects showed CMRglc reductions in the same regions as clinically affected AD patients, involving the posterior cingulate cortex/precuneus, parietotemporal and frontal cortices, and medial temporal lobes (P < 0.05, corrected for multiple comparisons). These effects remained significant after accounting for possible risk factors for AD, including age, gender, education, apolipoprotein E genotype, and subjective memory complaints. No CMRglc differences were found between FHp and FH(-) subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals.
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Maternal inheritance appears to determine several AD endophenotypes.
“Maternal inheritance appears to determine several AD endophenotypes.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [129]
Cognitively normal middle-aged children of AD mothers, but not AD fathers, show reduced cerebral glucose utilization on FDG PET.
“This study found that cognitively normal, middle-aged children of AD mothers, but not AD fathers, show reduced cerebral glucose utilization on fluorodeoxyglucose positron emission tomography (FDG PET).”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [129]
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Wilkins, H. M., Weidling, I., Koppel, S., Wang, X., von Schulze, A., & Swerdlow, R. H. (2018) · The Molecular and Cellular Basis of Neurodegenerative Diseases · doi:10.1016/b978-0-12-811304-2.00013-4 · Cited by 2 · see citing works
- Authors
- Mosconi, L., Brys, M., Switalski, R., Mistur, R., Glodzik, L., Pirraglia, E., Tsui, W., De Santi, S., & de Leon, M. J.
- Affiliations
- New York University (US)
- *Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and
- Nathan Kline Institute for Psychiatric Research (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-11-27
- Volume
- 104
- Issue
- 48
- Pages
- 19067-19072
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2141909
- OpenAlex
- W1983761458
- Cited by
- 237
- References
- 56
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 18 · 2019: 7 · 2018: 14 · 2017: 11 · 2016: 8 · 2015: 10 · 2014: 21 · 2013: 17 · 2012: 19
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association
- National Institutes of Health (AG12101, AG08051)
- National Institute on Aging (AG022374, R01AG022374, AG 12101, R01AG012101, P30AG008051, AG 08051, R01AG013616, AG 13616)
- National Center for Research Resources (M01RR000096)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, family history (medicine), maternal inheritance, brain glucose metabolism, cognitively normal older adults, parental risk, posterior cingulate cortex, precuneus, medial temporal lobe, temporoparietal cortex, apolipoprotein E, gender differences
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain Mapping, Cerebral Cortex, Female, Fluorine Radioisotopes, Glucose, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mothers, Retrospective Studies, Risk, Genomic Imprinting, Genetic Heterogeneity, Fluorodeoxyglucose F18, Genetic Predisposition to Disease, Positron-Emission Tomography, Genes, Mitochondrial, Apolipoprotein E4
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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