Spatiotemporal Imaging of Glutamate-Induced Biophotonic Activities and Transmission in Neural Circuits
Open accessAbstract
The processing of neural information in neural circuits plays key roles in neural functions. Biophotons, also called ultra-weak photon emissions (UPE), may play potential roles in neural signal transmission, contributing to the understanding of the high functions of nervous system such as vision, learning and memory, cognition and consciousness. However, the experimental analysis of biophotonic activities (emissions) in neural circuits has been hampered due to technical limitations. Here by developing and optimizing an in vitro biophoton imaging method, we characterize the spatiotemporal biophotonic activities and transmission in mouse brain slices. We show that the long-lasting application of glutamate to coronal brain slices produces a gradual and significant increase of biophotonic activities and achieves the maximal effect within approximately 90 min, which then lasts for a relatively long time (>200 min). The initiation and/or maintenance of biophotonic activities by glutamate can be significantly blocked by oxygen and glucose deprivation, together with the application of a cytochrome c oxidase inhibitor (sodium azide), but only partly by an action potential inhibitor (TTX), an anesthetic (procaine), or the removal of intracellular and extracellular Ca(2+). We also show that the detected biophotonic activities in the corpus callosum and thalamus in sagittal brain slices mostly originate from axons or axonal terminals of cortical projection neurons, and that the hyperphosphorylation of microtubule-associated protein tau leads to a significant decrease of biophotonic activities in these two areas. Furthermore, the application of glutamate in the hippocampal dentate gyrus results in increased biophotonic activities in its intrahippocampal projection areas. These results suggest that the glutamate-induced biophotonic activities reflect biophotonic transmission along the axons and in neural circuits, which may be a new mechanism for the processing of neural information.
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- Authors
- Tang, R., & Dai, J.
- Affiliations
- South Central Minzu University (CN)
- Corresponding author
- Dai, Jiapei
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-01-15
- Volume
- 9
- Issue
- 1
- Pages
- e85643
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3893221
- OpenAlex
- W1977345460
- Cited by
- 91
- References
- 45
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 2 · 2013: 1
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (31070961)
- South-Central University for Nationalities (XJS09001)
- Topics
- Health Sciences › Medicine › Physiology › Biofield Effects and Biophysics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- biophotons, ultraweak photon emission, glutamate, neural transmission, neural circuits, oxygen-glucose deprivation, sodium azide, tau hyperphosphorylation, corpus callosum, thalamus, dentate gyrus, cortical projection neurons, mouse brain slices
- MeSH terms
- Action Potentials, Animals, Luminescent Measurements, Male, Nerve Net, Synaptic Transmission, Neurons, Glutamic Acid, Dentate Gyrus, Luminescence, Mice, In Vitro Techniques
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