Optogenetic investigation of neural circuits underlying brain disease in animal models
Open accessAbstract
Optogenetic tools have provided a new way to establish causal relationships between brain activity and behaviour in health and disease. Although no animal model captures human disease precisely, behaviours that recapitulate disease symptoms may be elicited and modulated by optogenetic methods, including behaviours that are relevant to anxiety, fear, depression, addiction, autism and parkinsonism. The rapid proliferation of optogenetic reagents together with the swift advancement of strategies for implementation has created new opportunities for causal and precise dissection of the circuits underlying brain diseases in animal models.
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In fear- or anxiety-provoking circumstances, projections from the BLA targeting the central amygdala and the BNST are activated.
“in fear- or anxiety-provoking circumstances, projections from the BLA targeting the central amygdala (CeA, containing the lateral (CeL) and medial (CeM) subdivisions)53,64 and the BNST31,65 are activated.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [64]
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Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786 · see citing works
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., et al. (2013) · Nature · doi:10.1038/nature11740 · Cited by 1,073 · see citing works
Self-citationModelling and analysis of local field potentials for studying the function of cortical circuits
Einevoll, G. T., Kayser, C., Logothetis, N. K., & Panzeri, S. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3599 · Cited by 857 · see citing works
Reward and aversion in a heterogeneous midbrain dopamine system
Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804 · see citing works
Geddes, J. R., & Miklowitz, D. J. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60857-0 · Cited by 848 · see citing works
Resolving the neural circuits of anxiety
Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766 · see citing works
Self-citationSynaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens
Britt, J. P., Benaliouad, F., McDevitt, R. A., Stuber, G. D., Wise, R. A., & Bonci, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.040 · Cited by 716 · see citing works
Dopamine system dysregulation in major depressive disorders
Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754 · see citing works
Canales, A., Jia, X., Froriep, U. P., Koppes, R. A., Tringides, C. M., Selvidge, J., Lu, C., Hou, C., Wei, L., Fink, Y., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3093 · Cited by 668 · see citing works
The Effects of Psychological Stress on Depression
Yang, L., Zhao, Y., Wang, Y., Liu, L., Zhang, X., Li, B., & Cui, R. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831150507 · Cited by 589 · see citing works
BLA to vHPC inputs modulate anxiety-related behaviors
Felix-Ortiz, A. C., Beyeler, A., Seo, C., Leppla, C. A., Wildes, C. P., & Tye, K. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.016 · Cited by 592 · see citing works
Self-citationMechanisms of epileptogenesis: a convergence on neural circuit dysfunction
Goldberg, E. M., & Coulter, D. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3482 · Cited by 542 · see citing works
The endocannabinoid system in guarding against fear, anxiety and stress
Lutz, B., Marsicano, G., Maldonado, R., & Hillard, C. J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4036 · Cited by 506 · see citing works
Encoding of fear learning and memory in distributed neuronal circuits
Herry, C., & Johansen, J. P. (2014) · Nature Neuroscience · doi:10.1038/nn.3869 · Cited by 474 · see citing works
Animal models of major depression and their clinical implications
Czéh, B., Fuchs, E., Wiborg, O., & Simon, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.004 · Cited by 375 · see citing works
Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling
Poulin, J.-F., Zou, J., Drouin-Ouellet, J., Kim, K.-Y. A., Cicchetti, F., & Awatramani, R. B. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.008 · Cited by 352 · see citing works
Park, S., Yuk, H., Zhao, R., Yim, Y. S., Woldeghebriel, E. W., Kang, J., Canales, A., Fink, Y., Choi, G. B., Zhao, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23802-9 · Cited by 312 · see citing works
Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit
Anthony, T. E., Dee, N., Bernard, A., Lerchner, W., Heintz, N., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2013.12.040 · Cited by 310 · see citing works
Fuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414728112 · Cited by 265 · see citing works
Optogenetic inhibition of behavior with anion channelrhodopsins
Mohammad, F., Stewart, J. C., Ott, S., Chlebikova, K., Chua, J. Y., Koh, T.-W., Ho, J., & Claridge-Chang, A. (2017) · Nature Methods · doi:10.1038/nmeth.4148 · Cited by 276 · see citing works
A Bayesian Model of Category-Specific Emotional Brain Responses
Wager, T. D., Kang, J., Johnson, T. D., Nichols, T. E., Satpute, A. B., & Barrett, L. F. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004066 · Cited by 262 · see citing works
Normal and abnormal coding of somatosensory stimuli causing pain
Prescott, S. A., Ma, Q., & De Koninck, Y. (2014) · Nature Neuroscience · doi:10.1038/nn.3629 · Cited by 210 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
McDevitt, R. A., Tiran-Cappello, A., Shen, H., Balderas, I., Britt, J. P., Marino, R. A. M., Chung, S. L., Richie, C. T., Harvey, B. K., & Bonci, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.037 · Cited by 203 · see citing works
Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit
D'Agostino, G., Lyons, D. J., Cristiano, C., Burke, L. K., Madara, J. C., Campbell, J. N., Garcia, A. P., Land, B. B., Lowell, B. B., Dileone, R. J., et al. (2016) · eLife · doi:10.7554/elife.12225 · Cited by 193 · see citing works
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150 · see citing works
Self-citationOptogenetic inactivation modifies monkey visuomotor behavior
Cavanaugh, J., Monosov, I. E., McAlonan, K., Berman, R., Smith, M. K., Cao, V., Wang, K. H., Boyden, E. S., & Wurtz, R. H. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.016 · Cited by 124 · see citing works
Manipulating a “Cocaine Engram” in Mice
Hsiang, H.-L. (., Epp, J. R., van den Oever, M. C., Yan, C., Rashid, A. J., Insel, N., Ye, L., Niibori, Y., Deisseroth, K., Frankland, P. W., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-14.2014 · Cited by 131 · see citing works
Self-citationGenetic approaches to hypothalamic-pituitary-adrenal axis regulation
Arnett, M. G., Muglia, L. M., Laryea, G., & Muglia, L. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.215 · Cited by 105 · see citing works
Optical Stimulation of Neurons
C. Thompson, A., R. Stoddart, P., & Jansen, E. D. (2015) · Current Molecular Imaging · doi:10.2174/2211555203666141117220611 · Cited by 105 · see citing works
“Optogenetics have been utilised to further our understanding of neural disorders [36], understand neural systems and encoding [37] and there is interest in using optogenetics to treat blindness and Parkinson’s disease [17, 38, 39].”
BackgroundProgress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works
Self-citationErmakova, A. O., Knolle, F., Justicia, A., Bullmore, E. T., Jones, P. B., Robbins, T. W., Fletcher, P. C., & Murray, G. K. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0056-2 · Cited by 91 · see citing works
Murray, J. E., Belin-Rauscent, A., Simon, M., Giuliano, C., Benoit-Marand, M., Everitt, B. J., & Belin, D. (2015) · Nature Communications · doi:10.1038/ncomms10088 · Cited by 97 · see citing works
Optogenetically induced seizure and the longitudinal hippocampal network dynamics
Osawa, S.-I., Iwasaki, M., Hosaka, R., Matsuzaka, Y., Tomita, H., Ishizuka, T., Sugano, E., Okumura, E., Yawo, H., Nakasato, N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060928 · Cited by 96 · see citing works
Tang, R., & Dai, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085643 · Cited by 91 · see citing works
Deep learning applied to electroencephalogram data in mental disorders: a systematic review
de Bardeci, M., Ip, C. T., & Olbrich, S. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108117 · Cited by 71 · see citing works
Menon, V., Cerri, D., Lee, B., Yuan, R., Lee, S.-H., & Shih, Y.-Y. I. (2023) · Nature Communications · doi:10.1038/s41467-023-36616-8 · Cited by 53 · see citing works
Tools for Resolving Functional Activity and Connectivity within Intact Neural Circuits
Jennings, J. H., & Stuber, G. D. (2014) · Current Biology · doi:10.1016/j.cub.2013.11.042 · Cited by 54 · see citing works
Hiremath, S. V., Chen, W., Wang, W., Foldes, S., Yang, Y., Tyler-Kabara, E. C., Collinger, J. L., & Boninger, M. L. (2015) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00040 · Cited by 53 · see citing works
Systems Neuroengineering: Understanding and Interacting with the Brain
Edelman, B. J., Johnson, N., Sohrabpour, A., Tong, S., Thakor, N., & He, B. (2015) · Engineering · doi:10.15302/j-eng-2015078 · Cited by 45 · see citing works
Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice
Sooksawate, T., Isa, K., Matsui, R., Kato, S., Kinoshita, M., Kobayashi, K., Watanabe, D., Kobayashi, K., & Isa, T. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00162 · Cited by 46 · see citing works
Xie, Y., Chen, S., Wu, Y., & Murphy, T. H. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1775-14.2014 · Cited by 35 · see citing works
Fifel, K., Piggins, H., & Deboer, T. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.02.005 · Cited by 30 · see citing works
Neural Circuit Reprogramming: A New Paradigm for Treating Neuropsychiatric Disease?
Tye, K. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.022 · Cited by 21 · see citing works
Self-citationDesign Considerations for Implantable Neural Circuits and Systems
Hsu, W.-Y., Hsieh, P.-H., & Chen, H. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_19 · Cited by 1 · see citing works
- Authors
- Tye, K. M., & Deisseroth, K.
- Affiliations
- Stanford University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Tye, Kay M.
- Deisseroth, Karl
- Venue
- Nature Reviews Neuroscience
- Published
- 2012-03-20
- Volume
- 13
- Issue
- 4
- Pages
- 251-266
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC6682316
- OpenAlex
- W2160779028
- Cited by
- 745
- References
- 203
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 29 · 2023: 34 · 2022: 35 · 2021: 41 · 2020: 53 · 2019: 46 · 2018: 48 · 2017: 81 · 2016: 65 · 2015: 96 · 2014: 74 · 2013: 71 · 2012: 21
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Mental Health (F32MH088010)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- optogenetics, neural circuits, brain disorders, mental illness, neurological disorders, animal models of disease, anxiety, fear, depression, addiction, autism spectrum disorder, parkinsonism
- MeSH terms
- Animals, Brain Diseases, Disease Models, Animal, Nerve Net, Neurons, Neuroimaging
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