Cited by 745Photoreceptor and optogenetics researchNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Optogenetic investigation of neural circuits underlying brain disease in animal models

Open access
Tye, Kay M., Deisseroth, Karl·2012·Nature Reviews Neuroscience

Abstract

Optogenetic tools have provided a new way to establish causal relationships between brain activity and behaviour in health and disease. Although no animal model captures human disease precisely, behaviours that recapitulate disease symptoms may be elicited and modulated by optogenetic methods, including behaviours that are relevant to anxiety, fear, depression, addiction, autism and parkinsonism. The rapid proliferation of optogenetic reagents together with the swift advancement of strategies for implementation has created new opportunities for causal and precise dissection of the circuits underlying brain diseases in animal models.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nrn3171

Cites

203 of 203 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In fear- or anxiety-provoking circumstances, projections from the BLA targeting the central amygdala and the BNST are activated.

    “in fear- or anxiety-provoking circumstances, projections from the BLA targeting the central amygdala (CeA, containing the lateral (CeL) and medial (CeM) subdivisions)53,64 and the BNST31,65 are activated.”

    From Resolving the neural circuits of anxiety (2015) · cites this paper as [64]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [111]Carr GD, Fibiger HC & Phillips AG Conditioned place preference as a measure of drug reward in The Neuropharmacological Basis of Reward (Topics in Experimental Psychopharmacology) Vol. 1 (eds Liebman JM& Cooper SJ) 264– 319 (Oxford Univ. Press, 1989).

Cited by

Sorted by citations

Authors
Tye, K. M., & Deisseroth, K.
Affiliations
  • Stanford University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
  • Tye, Kay M.
  • Deisseroth, Karl
Venue
Nature Reviews Neuroscience
Published
2012-03-20
Volume
13
Issue
4
Pages
251-266
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2160779028
Cited by
745
References
203
Citations by year
2026: 19 · 2025: 30 · 2024: 29 · 2023: 34 · 2022: 35 · 2021: 41 · 2020: 53 · 2019: 46 · 2018: 48 · 2017: 81 · 2016: 65 · 2015: 96 · 2014: 74 · 2013: 71 · 2012: 21
FWCI
8.83
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Mental Health (F32MH088010)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
optogenetics, neural circuits, brain disorders, mental illness, neurological disorders, animal models of disease, anxiety, fear, depression, addiction, autism spectrum disorder, parkinsonism
MeSH terms
Animals, Brain Diseases, Disease Models, Animal, Nerve Net, Neurons, Neuroimaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review