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Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

Festuccia, William T., Pouliot, Philippe, Bakan, Inan, Sabatini, David M., Laplante, Mathieu·2014·PLoS ONE
DOI 10.1371/journal.pone.0095432PMC PMC3989321
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  1. S Gordon, 2003, Alternative activation of macrophages, Nat Rev Immunol, 3, 23, 10.1038/nri978 · DOI · Paper page
  2. T Kawai, 2010, The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors, Nat Immunol, 11, 373, 10.1038/ni.1863 · DOI · Paper page
  3. LA O’Neill, 2009, Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer, Pharmacol Rev, 61, 177, 10.1124/pr.109.001073 · DOI
  4. JM Olefsky, 2010, Macrophages, inflammation, and insulin resistance, Annu Rev Physiol, 72, 219, 10.1146/annurev-physiol-021909-135846 · DOI · Paper page
  5. JA Engelman, 2006, The Role of the ErbB Family Members in Non-Small Cell “Lung Cancers Sensitive to Epidermal Growth Factor Receptor Kinase Inhibitors”, Clin Cancer Res, 12, 4372s, 10.1158/1078-0432.CCR-06-0795 · DOI
  6. BD Manning, 2007, AKT/PKB signaling: navigating downstream, Cell, 129, 1261, 10.1016/j.cell.2007.06.009 · DOI · Paper page
  7. J Brown, 2011, TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk, J Dent Res, 90, 417, 10.1177/0022034510381264 · DOI
  8. K Hazeki, 2007, Role of phosphoinositide 3-kinase in innate immunity, Biol Pharm Bull, 30, 1617, 10.1248/bpb.30.1617 · DOI
  9. TD Troutman, 2012, Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K, Cell Cycle, 11, 3559, 10.4161/cc.21572 · DOI
  10. TD Troutman, 2012, Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt, Proc Natl Acad Sci U S A, 109, 273, 10.1073/pnas.1118579109 · DOI
  11. L Arbibe, 2000, Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway, Nat Immunol, 1, 533, 10.1038/82797 · DOI
  12. SN Sarkar, 2004, Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling, Nat Struct Mol Biol, 11, 1060, 10.1038/nsmb847 · DOI
  13. SH Rhee, 2006, Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells, J Biol Chem, 281, 18560, 10.1074/jbc.M513861200 · DOI · Paper page
  14. M Ni, 2012, B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K, Proc Natl Acad Sci U S A, 109, 267, 10.1073/pnas.1111957108 · DOI
  15. J Brown, 2011, Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1, J Biol Chem, 286, 44295, 10.1074/jbc.M111.258053 · DOI
  16. VA McGuire, 2013, Cross Talk between the Akt and p38alpha Pathways in Macrophages Downstream of Toll-Like Receptor Signaling, Mol Cell Biol, 33, 4152, 10.1128/MCB.01691-12 · DOI
  17. M Ojaniemi, 2003, Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages, Eur J Immunol, 33, 597, 10.1002/eji.200323376 · DOI
  18. B Chaurasia, 2010, Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages, Mol Cell Biol, 30, 4354, 10.1128/MCB.00069-10 · DOI
  19. A Arranz, 2012, Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization, Proc Natl Acad Sci U S A, 109, 9517, 10.1073/pnas.1119038109 · DOI
  20. M Laplante, 2012, mTOR signaling in growth control and disease, Cell, 149, 274, 10.1016/j.cell.2012.03.017 · DOI · Paper page
  21. DA Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1, Dev Cell, 11, 859, 10.1016/j.devcel.2006.10.007 · DOI
  22. C Shiota, 2006, Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability, Dev Cell, 11, 583, 10.1016/j.devcel.2006.08.013 · DOI
  23. BE Clausen, 1999, Conditional gene targeting in macrophages and granulocytes using LysMcre mice, Transgenic Res, 8, 265, 10.1023/A:1008942828960 · DOI · Paper page
  24. DR Alessi, 1997, Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha, Curr Biol, 7, 261, 10.1016/S0960-9822(06)00122-9 · DOI
  25. JM Garcia-Martinez, 2008, mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1), Biochem J, 416, 375, 10.1042/BJ20081668 · DOI · Paper page
  26. E Jacinto, 2006, SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity, Cell, 127, 125, 10.1016/j.cell.2006.08.033 · DOI
  27. R Cancello, 2006, Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity, Diabetes, 55, 1554, 10.2337/db06-0133 · DOI · Paper page
  28. H Xu, 2003, Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance, J Clin Invest, 112, 1821, 10.1172/JCI200319451 · DOI · Paper page
  29. GS Habicht, 1981, Body temperature in normal and endotoxin-treated mice of different ages, Mech Ageing Dev, 16, 97, 10.1016/0047-6374(81)90037-3 · DOI
  30. F Bauss, 1987, Tumor necrosis factor mediates endotoxic effects in mice, Infect Immun, 55, 1622, 10.1128/IAI.55.7.1622-1625.1987 · DOI
  31. M Martin, 2005, Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3, Nat Immunol, 6, 777, 10.1038/ni1221 · DOI
  32. W Fan, 2010, FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages, EMBO J, 29, 4223, 10.1038/emboj.2010.268 · DOI
  33. MF Siqueira, 2010, Impaired wound healing in mouse models of diabetes is mediated by TNF-alpha dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1), Diabetologia, 53, 378, 10.1007/s00125-009-1529-y · DOI
  34. D Su, 2009, FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages, Diabetes, 58, 2624, 10.2337/db09-0232 · DOI
  35. Y Kawano, 2012, Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance, Diabetes, 61, 1935, 10.2337/db11-0770 · DOI
  36. R Cancello, 2006, Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue, Bjog, 113, 1141, 10.1111/j.1471-0528.2006.01004.x · DOI · Paper page
  37. K Cusi, 2010, The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes, Curr Diab Rep, 10, 306, 10.1007/s11892-010-0122-6 · DOI
  38. SP Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J Clin Invest, 112, 1796, 10.1172/JCI200319246 · DOI · Paper page
  39. GS Hotamisligil, 2006, Inflammation and metabolic disorders, Nature, 444, 860, 10.1038/nature05485 · DOI · Paper page
  40. V Hietakangas, 2007, Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth, Genes Dev, 21, 632, 10.1101/gad.416307 · DOI
  41. JP Luyendyk, 2008, Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages, J Immunol, 180, 4218, 10.4049/jimmunol.180.6.4218 · DOI
  42. G Schabbauer, 2004, PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice, Arterioscler Thromb Vasc Biol, 24, 1963, 10.1161/01.ATV.0000143096.15099.ce · DOI
  43. B Zou, 2012, Timing of insulin therapy affects the inflammatory response in endotoxemic rats, Inflammation, 35, 723, 10.1007/s10753-011-9367-8 · DOI
  44. MG Jeschke, 2004, Insulin attenuates the systemic inflammatory response in endotoxemic rats, Endocrinology, 145, 4084, 10.1210/en.2004-0592 · DOI

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Metadata

Authors
Festuccia, W. T., Pouliot, P., Bakan, I., Sabatini, D. M., & Laplante, M.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-04-16
Volume
9
Issue
4
Pages
e95432
ISSN
1932-6203
DOI
10.1371/journal.pone.0095432
PMC
PMC3989321
Cited by
103
References
14
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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