Dietary Patterns Differently Associate with Inflammation and Gut Microbiota in Overweight and Obese Subjects
Open accessAbstract
BACKGROUND: Associations between dietary patterns, metabolic and inflammatory markers and gut microbiota are yet to be elucidated. OBJECTIVES: We aimed to characterize dietary patterns in overweight and obese subjects and evaluate the different dietary patterns in relation to metabolic and inflammatory variables as well as gut microbiota. DESIGN: Dietary patterns, plasma and adipose tissue markers, and gut microbiota were evaluated in a group of 45 overweight and obese subjects (6 men and 39 women). A group of 14 lean subjects were also evaluated as a reference group. RESULTS: Three clusters of dietary patterns were identified in overweight/obese subjects. Cluster 1 had the least healthy eating behavior (highest consumption of potatoes, confectionary and sugary drinks, and the lowest consumption of fruits that was associated also with low consumption of yogurt, and water). This dietary pattern was associated with the highest LDL cholesterol, plasma soluble CD14 (p = 0.01) a marker of systemic inflammation but the lowest accumulation of CD163+ macrophages with anti-inflammatory profile in adipose tissue (p = 0.05). Cluster 3 had the healthiest eating behavior (lower consumption of confectionary and sugary drinks, and highest consumption of fruits but also yogurts and soups). Subjects in this Cluster had the lowest inflammatory markers (sCD14) and the highest anti-inflammatory adipose tissue CD163+ macrophages. Dietary intakes, insulin sensitivity and some inflammatory markers (plasma IL6) in Cluster 3 were close to those of lean subjects. Cluster 2 was in-between clusters 1 and 3 in terms of healthfulness. The 7 gut microbiota groups measured by qPCR were similar across the clusters. However, the healthiest dietary cluster had the highest microbial gene richness, as evaluated by quantitative metagenomics. CONCLUSION: A healthier dietary pattern was associated with lower inflammatory markers as well as greater gut microbiota richness in overweight and obese subjects. TRIAL REGISTRATION: ClinicalTrials.gov NCT01314690.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gut microbiota are affected by environmental factors such as dietary intakes, which may in turn influence blood levels of TMAO and its precursors.
“Fourth, the gut microbiota are affected by environmental factors37, 38 such as dietary intakes,39, 40, 41 which may, in turn, influence blood levels of TMAO and its precursors.4”
From Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies (2017) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Self-citationLinking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Self-citationFundamentals of Biostatistics.
(1969) · Annals of Internal Medicine · doi:10.7326/0003-4819-70-4-873 · Cited by 4,573 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · cited 1× · see citing works
“macrophage activation, are prone to diet-induced obesity and insulin resistance [40].”
BackgroundDietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works
Self-citationHealth-promoting components of fruits and vegetables in the diet.
Liu, R. H. (2013) · Advances in Nutrition · doi:10.3945/an.112.003517 · Cited by 1,310 · see citing works
Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss
Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works
Self-citationMarkers of the Validity of Reported Energy Intake
Livingstone, M. B. E., & Black, A. E. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.3.895s · Cited by 1,081 · see citing works
Prospective study of major dietary patterns and risk of coronary heart disease in men
Hu, F. B., Rimm, E. B., Stampfer, M. J., Ascherio, A., Spiegelman, D. L., & Willett, W. C. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.912 · Cited by 1,056 · see citing works
Dietary patterns and health outcomes
Kant, A. K. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.01.010 · Cited by 1,024 · see citing works
Lopez-Garcia, E., Schulze, M. B., Fung, T. T., Meigs, J. B., Rifai, N., Manson, J. E., & Hu, F. B. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.1029 · Cited by 881 · see citing works
Liu, S., Willett, W. C., Manson, J. E., Hu, F. B., Rosner, B., & Colditz, G. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.5.920 · Cited by 787 · see citing works
Dietary Patterns and the Risk of Coronary Heart Disease in Women
Fung, T. T., Willett, W. C., Stampfer, M. J., Manson, J. E., & Hu, F. B. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.15.1857 · Cited by 549 · see citing works
Dietary Patterns and Markers of Systemic Inflammation among Iranian Women
Esmaillzadeh, A., Kimiagar, M., Mehrabi, Y., Azadbakht, L., Hu, F. B., & Willett, W. C. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.4.992 · Cited by 405 · see citing works
Aron‐Wisnewsky, J., Tordjman, J., Poitou, C., Darakhshan, F., Hugol, D., Basdevant, A., Aissat, A., Guerre-Millo, M., & Clément, K. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0925 · Cited by 379 · see citing works
Self-citationBouché, C., Rizkalla, S. W., Luo, J., Vidal, H., Véronèse, A., Pacher, N., Fouquet, C., Lang, V., & Slama, G. (2002) · Diabetes Care · doi:10.2337/diacare.25.5.822 · Cited by 287 · see citing works
Self-citationDietary patterns, inflammation and the metabolic syndrome
Ahluwalia, N., Andreeva, V. A., Kesse‐Guyot, E., & Herçberg, S. (2012) · Diabetes & Metabolism · doi:10.1016/j.diabet.2012.08.007 · Cited by 273 · see citing works
Sluijs, I., Forouhi, N. G., Beulens, J. W., van der Schouw, Y. T., Agnoli, C., Arriola, L., Balkau, B., Barricarte, A., Boeing, H., Bueno-de-Mesquita, H. B., et al. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.021907 · Cited by 223 · see citing works
Dietary Patterns and Changes in Body Weight in Women
Schulze, M. B., Fung, T. T., Manson, J. E., Willett, W. C., & Hu, F. B. (2006) · Obesity · doi:10.1038/oby.2006.164 · Cited by 220 · see citing works
Adherence to Mediterranean diet reduces the risk of metabolic syndrome: A 6-year prospective study
Kesse‐Guyot, E., Ahluwalia, N., Lassale, C. M., Herçberg, S., Fezeu, L., & Lairon, D. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.02.005 · Cited by 216 · see citing works
Schulze, M. B., Hoffmann, K., Kroke, A., & Boeing, H. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2000254 · Cited by 198 · see citing works
O’Connor, L. M., Lentjes, M. A. H., Luben, R., Khaw, K., Wareham, N. J., & Forouhi, N. G. (2014) · Diabetologia · doi:10.1007/s00125-014-3176-1 · Cited by 182 · see citing works
Buijsse, B., Feskens, E. J., Schulze, M. B., Forouhi, N. G., Wareham, N. J., Sharp, S., Palli, D., Tognon, G., Halkjaer, J., Tjønneland, A., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27394 · Cited by 153 · see citing works
Food Groups as Predictors for Short-Term Weight Changes in Men and Women of the EPIC-Potsdam Cohort
Schulz, M., Kroke, A., Hoffmann, K., Bergmann, M. M., Boeing, H., & Liese, A. D. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1335 · Cited by 143 · see citing works
Tam, C. S., Viardot, A., Clément, K., Tordjman, J., Tonks, K. T. T., Greenfield, J. R., Campbell, L. V., Samocha‐Bonet, D., & Heilbronn, L. K. (2010) · Diabetes · doi:10.2337/db10-0162 · Cited by 126 · see citing works
Self-citationMcNaughton, S. A., Mishra, G. D., Stephen, A. M., & Wadsworth, M. E. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.99 · Cited by 124 · see citing works
Costacou, T., Bamia, C., Ferrari, P., Ríboli, E., Trichopoulos, D., & Trichopoulou, A. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601699 · Cited by 112 · see citing works
Fujisaka, S., Usui, I., Kanatani, Y., Ikutani, M., Takasaki, I., Tsuneyama, K., Tabuchi, Y., Bukhari, A., Yamazaki, Y., Suzuki, H., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1312 · Cited by 105 · see citing works
Newby, P. K., Weismayer, C., Åkesson, A., Tucker, K. L., & Wolk, A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2580 · Cited by 101 · see citing works
Vergnaud, A., Norat, T., Romaguera, D., Mouw, T., May, A. M., Romieu, I., Freisling, H., Slimani, N., Boutron‐Ruault, M., Clavel‐Chapelon, F., et al. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.019968 · Cited by 96 · see citing works
Dietary patterns, insulin sensitivity and inflammation in older adults
Anderson, A. L., Harris, T. B., Tylavsky, F. A., Perry, S. E., Houston, D. K., Lee, J. S., Kanaya, A. M., Sahyoun, N. R., & Study, F. T. H. A. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.162 · Cited by 93 · see citing works
Rizkalla, S. W., Prifti, E., Cotillard, A., Pelloux, V., Rouault, C., Allouche, R., Laromiguière, M., Kong, L., Darakhshan, F., Massiéra, F., et al. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.017277 · Cited by 66 · see citing works
Self-citationEstaquio, C., Castetbon, K., Kesse‐Guyot, E., Bertrais, S., Deschamps, V., Dauchet, L., Péneau, S., Galan, P., & Herçberg, S. (2008) · Journal of Nutrition · doi:10.1093/jn/138.5.946 · Cited by 62 · see citing works
Cani, P. D., & Delzenne, N. M. (2010) · PubMed · Cited by 60 · see citing works
Self-citationCastetbon, K., Vernay, M., Deschamps, V., Salanave, B., Malon, A., & Herçberg, S. (2008) · Obésité · doi:10.1007/s11690-008-0104-x · Cited by 52 · see citing works
Griep, L. M. O., Wang, H., & Chan, Q. M. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0045-3 · Cited by 50 · see citing works
Castetbon, K., Bonaldi, C., Deschamps, V., Vernay, M., Malon, A., Salanave, B., & Druet, C. (2013) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.08.002 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [27]Habi-Rachedi F, Rondeau P, Marque S, Holmes B (2012) A robust multivariate analysis to identify dietary patterns. Agrostat; 12th European symposium on statistical methods for the food industry. Paris. France 28/02-2/02.
Cited by
Sorted by citations
Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931 · see citing works
Self-citationEnergy balance and obesity: what are the main drivers?
On behalf of the IARC working group on Energy Balance and Obesity, Romieu, I., Dossus, L., Barquera, S., Blottière, H. M., Franks, P. W., Gunter, M. J., Hwalla, N. C., Hursting, S. D., Leitzmann, M. F., et al. (2017) · Cancer Causes & Control · doi:10.1007/s10552-017-0869-z · Cited by 745 · see citing works
Immune Dysfunction as a Cause and Consequence of Malnutrition
Bourke, C. D., Berkley, J. A., & Prendergast, A. J. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.003 · Cited by 732 · see citing works
Wallace, T. C., Bailey, R. L., Blumberg, J. B., Burton-Freeman, B., Chen, C.-Y. O., Crowe-White, K. M., Drewnowski, A., Hooshmand, S., Johnson, E., Lewis, R., et al. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1632258 · Cited by 638 · see citing works
Heianza, Y., Ma, W., Manson, J. E., Rexrode, K. M., & Qi, L. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004947 · Cited by 544 · see citing works
Gut microbiota, obesity and diabetes
Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133285 · Cited by 552 · see citing works
Prebiotics: why definitions matter
Hutkins, R., Krumbeck, J. A., Bindels, L., Cani, P. D., Fahey, G., Goh, Y., Hamaker, B., Martens, E., Mills, D., Rastal, R. A., et al. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.09.001 · Cited by 407 · see citing works
Self-citationFactors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes
Li, W., & Duffy, A. J. (2017) · Journal of Nutrition · doi:10.3945/jn.116.240754 · Cited by 419 · see citing works
Probiotics in prevention and treatment of obesity: a critical view
Kobyliak, N. M., Conte, C., Cammarota, G., Haley, A. P., Štyriak, I., Gašpar, Ľ., Fusek, J., Rodrigo, L., & Kružliak, P. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0067-0 · Cited by 359 · see citing works
The gut microbiome, diet, and links to cardiometabolic and chronic disorders
Aron‐Wisnewsky, J., & Clément, K. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.191 · Cited by 327 · see citing works
Self-citationInterindividual variability in gut microbiota and host response to dietary interventions
Healey, G. R., Murphy, R., Brough, L., Butts, C. A., & Coad, J. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux062 · Cited by 296 · see citing works
Tomas, J., Mulet, C., Saffarian, A., Cavin, J., Ducroc, R. A., Regnault, B., Tan, C. K., Duszka, K., Burcelin, R., Wahli, W., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612559113 · Cited by 255 · see citing works
Hersoug, L., Möller, P., & Loft, S. H. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422417000269 · Cited by 246 · see citing works
Deehan, E. C., Duar, R. M., Armet, A. M., Pérez-Muñoz, M. E., Jin, M., & Walter, J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0019-2017 · Cited by 227 · see citing works
Contribution of macronutrients to obesity: implications for precision nutrition
San-Cristóbal, R., Navas‐Carretero, S., Martínez‐González, M. Á., Ordovás, J. M., & Martínez, J. A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0346-8 · Cited by 201 · see citing works
The influence of diet on the gut microbiota and its consequences for health
Dore, J. M., & Blottière, H. M. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.01.002 · Cited by 188 · see citing works
Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery
Debédat, J., Clément, K., & Aron‐Wisnewsky, J. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00351-3 · Cited by 156 · see citing works
Self-citationFecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes?
Aron‐Wisnewsky, J., Clément, K., & Nieuwdorp, M. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1180-z · Cited by 144 · see citing works
Self-citationSpecific properties of probiotic strains: relevance and benefits for the host
Bubnov, R. V., Babenko, L. P., Lazarenko, L. M., Mokrozub, V. V., & Spivak, M. Y. (2018) · The EPMA Journal · doi:10.1007/s13167-018-0132-z · Cited by 129 · see citing works
Röytiö, H., Mokkala, K., Vahlberg, T., & Laitinen, K. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517002100 · Cited by 128 · see citing works
Gut microbiota and obesity: Concepts relevant to clinical care
Dao, M. C., & Clément, K. (2017) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2017.10.005 · Cited by 129 · see citing works
Self-citationImpact of increasing fruit and vegetables and flavonoid intake on the human gut microbiota
Klinder, A., Shen, Q., Heppel, S., Lovegrove, J. A., Rowland, I. R., & Tuohy, K. M. (2016) · Food & Function · doi:10.1039/c5fo01096a · Cited by 128 · see citing works
Advances in dietary pattern analysis in nutritional epidemiology
Schulz, C., Oluwagbemigun, K., & Nöthlings, U. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02545-9 · Cited by 126 · see citing works
Islam, M. A., Khandker, S. S., Kotyla, P. J., & Hassan, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01477 · Cited by 131 · see citing works
Zheng, J., Hoffman, K. L., Chen, J., Shivappa, N., Sood, A., Browman, G. J., Dirba, D. D., Hanash, S., Wei, P., Hébert, J. R., et al. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520001853 · Cited by 119 · see citing works
Rethinking Diet to Aid Human–Microbe Symbiosis
Derrien, M., & Veiga, P. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.09.011 · Cited by 112 · see citing works
Moorthy, M., Chaiyakunapruk, N., Jacob, S. A., & Palanisamy, U. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.03.036 · Cited by 95 · see citing works
Fangmann, D., Theismann, E., Türk, K., Schulte, D. M., Relling, I., Hartmann, K., Keppler, J. K., Knipp, J.-R., Rehman, A., Heinsen, F., et al. (2017) · Diabetes Care · doi:10.2337/dc17-1967 · Cited by 104 · see citing works
Overall Dietary Quality Relates to Gut Microbiota Diversity and Abundance
Laitinen, K., & Mokkala, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081835 · Cited by 96 · see citing works
Zacarías, M. F., Collado, M. C., Gómez-Gallego, C., Flinck, H., Aittoniemi, J., Isolauri, E., & Salminen, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200305 · Cited by 95 · see citing works
de Moraes, A. C. F., de Almeida-Pititto, B., Fernandes, G. D. R., Gomes, E. P., Pereira, A. C., & Ferreira, S. R. G. (2017) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-017-0261-x · Cited by 93 · see citing works
Ciubotaru, I., Green, S. J., Kukreja, S. C., & Barengolts, E. I. (2015) · Translational research · doi:10.1016/j.trsl.2015.06.015 · Cited by 87 · see citing works
Glycemic index, glycemic load, and common psychological disorders
Haghighatdoost, F., Azadbakht, L., Keshteli, A. H., Feinle‐Bisset, C., Daghaghzadeh, H., Afshar, H., Feizi, A., Esmaillzadeh, A., & Adibi, P. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.105445 · Cited by 82 · see citing works
Gut Microbiota in Obesity and Metabolic Abnormalities: A Matter of Composition or Functionality?
Morán‐Ramos, S., López-Contreras, B. E., & Canizales‐Quinteros, S. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.11.003 · Cited by 86 · see citing works
Relationship between Diet and Non-alcoholic Fatty Liver Disease: A Review Article.
Mirmiran, P., Amirhamidi, Z., Ejtahed, H., Bahadoran, Z., & Azizi, F. (2017) · Europe PMC (PubMed Central) · Cited by 82 · see citing works
Mokkala, K., Houttu, N., Cansev, T., & Laitinen, K. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.05.003 · Cited by 82 · see citing works
Estrogens and female liver health
Chen, K. L., & Madak‐Erdogan, Z. (2017) · Steroids · doi:10.1016/j.steroids.2017.10.015 · Cited by 81 · see citing works
Khavandegar, A., Heidarzadeh, A., Angoorani, P., Hasani‐Ranjbar, S., Ejtahed, H., Larijani, B. A., & Qorbani, M. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01861-3 · Cited by 80 · see citing works
Plant-Based Fat, Dietary Patterns Rich in Vegetable Fat and Gut Microbiota Modulation
Muralidharan, J., Galié, S., Hernández‐Alonso, P., Bulló, M., & Salas‐Salvadó, J. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00157 · Cited by 76 · see citing works
Silveira, B. K. S., Oliveira, T. M. S., Andrade, P. A., Hermsdorff, H. H. M., Rosa, C. D. O. B., & Franceschini, S. D. C. C. (2018) · Cardiology Research and Practice · doi:10.1155/2018/4762575 · Cited by 75 · see citing works
Heinsen, F., Fangmann, D., Müller, N., Schulte, D. M., Rühlemann, M. C., Türk, K., Settgast, U., Lieb, W., Baines, J. F., Schreiber, S., et al. (2016) · Obesity Facts · doi:10.1159/000449506 · Cited by 75 · see citing works
Ranaivo, H., Thirion, F., Béra‐Maillet, C., Guilly, S., Simon, C., Sothier, M., Berghe, L. V. D., Feugier, N., Lambert-Porcheron, S., Dussous, I., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2044722 · Cited by 69 · see citing works
Self-citationLogan, A. C., Katzman, M. A., & Balanzá‐Martínez, V. (2015) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-015-0041-y · Cited by 69 · see citing works
Kanwal, S., Aliya, S., & Xin, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.558874 · Cited by 61 · see citing works
Exploring the microbiome in health and disease
Scotti, E., Boué, S., Sasso, G. L., Zanetti, F., Belcastro, V., Poussin, C., Sierro, N., Battey, J. N. D., Gimalac, A., Ivanov, N. V., et al. (2017) · Toxicology Research and Application · doi:10.1177/2397847317741884 · Cited by 55 · see citing works
Social Influences on Prevotella and the Gut Microbiome of Young Monkeys
Amaral, W. Z., Lubach, G. R., Proctor, A., Lyte, M., Phillips, G. J., & Coe, C. L. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000454 · Cited by 54 · see citing works
Wu, H. Y., Wu, F.-T., Zhou, Q., & Zhao, D.-P. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.649466 · Cited by 52 · see citing works
Differential impact of environmental factors on systemic and localized autoimmunity
Touil, H., Mounts, K., & Jager, P. L. D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147447 · Cited by 53 · see citing works
Vinberg, M., Ottesen, N. M., Meluken, I., Sørensen, N., Pedersen, O. B., Kessing, L. V., & Miskowiak, K. W. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12976 · Cited by 51 · see citing works
Kayser, B. D., Lhomme, M., Prifti, E., Cunha, C. D., Marquet, F., Chain, F., Naas, I., Pelloux, V., Dao, M. C., Kontush, A., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201801897r · Cited by 51 · see citing works
Self-citationUnderlying evidence for the health benefits of fermented foods in humans
Rul, F., Béra‐Maillet, C., Champomier‐Vergès, M., Mecherfi, K. E. E., Foligné, B., Michalski, M., Milenković, D., & Savary‐Auzeloux, I. (2022) · Food & Function · doi:10.1039/d1fo03989j · Cited by 45 · see citing works
Kayser, B. D., Prifti, E., Lhomme, M., Belda, E., Dao, M. C., Aron‐Wisnewsky, J., Cotillard, A., Kennedy, S., Pons, N., Chatelier, E. L., et al. (2019) · Metabolomics · doi:10.1007/s11306-019-1596-0 · Cited by 44 · see citing works
Self-citationLogan, A. C., Katzman, M. A., & Balanzá‐Martínez, V. (2015) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-014-0040-4 · Cited by 42 · see citing works
Verger, E. O., Armstrong, P., Nielsen, T., Chakaroun, R., Aron‐Wisnewsky, J., Gøbel, R. J., Schütz, T., Delaere, F., Gausserès, N., Clément, K., et al. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.10.030 · Cited by 39 · see citing works
Self-citationDao, M. C., Sokolovska, N., Brazeilles, R., Affeldt, S., Pelloux, V., Prifti, E., Chilloux, J., Verger, E. O., Kayser, B. D., Aron‐Wisnewsky, J., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01958 · Cited by 41 · see citing works
Self-citationDalvi, P. S., Yang, S. H., Swain, N., Kim, J., Saha, S., Bourdon, C., Zhang, L., Chami, R., & Bandsma, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199916 · Cited by 38 · see citing works
Vieira, A. D. S., de Souza, C. B., Padilha, M., Zoetendal, E. G., Smidt, H., Saad, S. M. I., & Venema, K. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11252-8 · Cited by 38 · see citing works
Pourreza, S., Khademi, Z., Mirzababaei, A., Yekaninejad, M. S., Sadeghniiat‐Haghighi, K., Naghshi, S., & Mirzaei, K. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14429 · Cited by 38 · see citing works
Gut Microbiome, Inflammation, and Cerebrovascular Function: Link Between Obesity and Cognition
Olsthoorn, L., Vreeken, D., & Kiliaan, A. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.761456 · Cited by 38 · see citing works
A systematic review of the effect of yogurt consumption on chronic diseases risk markers in adults
Dumas, A., Lapointe, A., Dugrenier, M., Provencher, V., Lamarche, B., & Desroches, S. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1341-7 · Cited by 38 · see citing works
Understanding the Burden and Management of Urinary Tract Infections in Women
Baimakhanova, B. B., САДАНОВ, А. К., Trenozhnikova, L. P., Balgimbaeva, A. S., Baimakhanova, G. B., Orasymbet, S., Tleubekova, D., Amangeldi, A., Жаиковна, Т. З., Nurgaliyeva, Z. Z., et al. (2025) · Diseases · doi:10.3390/diseases13020059 · Cited by 45 · see citing works
Losing weight for a better health: Role for the gut microbiota
Dao, M. C., Everard, A., Clément, K., & Cani, P. D. (2015) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2015.12.001 · Cited by 33 · see citing works
Self-citationBarengolts, E. I., Green, S. J., Chlipala, G. E., Layden, B. T., Eisenberg, Y., Priyadarshini, M., & Dugas, L. R. (2019) · Microorganisms · doi:10.3390/microorganisms7090320 · Cited by 33 · see citing works
Dore, J. M., Multon, M.-C., Béhier, J., Affagard, H., Andremont, A., Barthélémy, P., Batitsa, R., Bonneville, M., Bonny, C., Boyaval, G., et al. (2017) · Therapies · doi:10.1016/j.therap.2016.12.007 · Cited by 33 · see citing works
Immune Dysfunctions and Immunotherapy in Colorectal Cancer: The Role of Dendritic Cells
Gessani, S., & Belardelli, F. (2019) · Cancers · doi:10.3390/cancers11101491 · Cited by 31 · see citing works
Beneficial Flavonoid in Foods and Anti-obesity Effect
Liu, J., Cao, J., Li, Y., & Guo, F. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1923730 · Cited by 29 · see citing works
The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue
Poledne, R., Lesná, I. K., Králová, A., Froněk, J., & Čejková, S. (2016) · Journal of Lipid Research · doi:10.1194/jlr.p068015 · Cited by 29 · see citing works
Lim, Y. Y., Lee, Y. S., & Ooi, D. S. Q. (2020) · Biotechnology Journal · doi:10.1002/biot.202000013 · Cited by 26 · see citing works
Deehan, E. C., Duar, R. M., Armet, A. M., Pérez-Muñoz, M. E., Jin, M., & Walter, J. (2018) · ASM Press eBooks · doi:10.1128/9781555819705.ch20 · Cited by 27 · see citing works
Saha, A., Samadder, A., & Nandi, S. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666221201150933 · Cited by 23 · see citing works
Schizophrenia and obesity: May the gut microbiota serve as a link for the pathogenesis?
Wu, H., Liu, Y., Wang, J., Chen, S., Xie, L., & Wu, X. (2023) · iMeta · doi:10.1002/imt2.99 · Cited by 24 · see citing works
Andrade, P. A., Hermsdorff, H. H. M., Leite, J. I. A., Shivappa, N., Hébert, J. R., Henriques, H. K. F., & Rosa, C. D. O. B. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3530-3 · Cited by 23 · see citing works
Diet–Gut Microbiota Relations: Critical Appraisal of Evidence From Studies Using Metagenomics
Lotankar, M., Houttu, N., Mokkala, K., & Laitinen, K. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae192 · Cited by 22 · see citing works
Gao, X., Jia, H.-Y., Chen, G., Li, C., & Mo, H. (2020) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-020-3085-8 · Cited by 22 · see citing works
Demine, S., Tejerina, S., Bihin, B., Thiry, M., Reddy, N., Renard, P., Raes, M., Jadot, M., & Arnould, T. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25994 · Cited by 21 · see citing works
The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases
Kandasamy, S., Letchumanan, V., Hong, K., Chua, K.-O., Mutalib, N. A., Ng, A. L. O., Ming, L. C., Lim, H. X., Thurairajasingam, S., Law, J. W., et al. (2023) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000396 · Cited by 21 · see citing works
Bubnov, R. V., & Spivak, M. Y. (2023) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-3-031-19564-8_6 · Cited by 21 · see citing works
Incidence of Urinary Infections and Behavioral Risk Factors
Mititelu, M., Olteanu, G., Neacșu, S. M., Stoicescu, I., Dumitrescu, D. E., Gheorghe, E., Tarcea, M., Busnatu, Ș., Ioniță-Mîndrican, C.-B., Tafuni, O. I., et al. (2024) · Nutrients · doi:10.3390/nu16030446 · Cited by 17 · see citing works
Khan, Q. A., Asad, M., Ali, A. H., Farrukh, A. M., Naseem, U., Semakieh, B., Levin-Carrion, Y., & Afzal, M. (2024) · Medicine · doi:10.1097/md.0000000000037825 · Cited by 17 · see citing works
Gut Microbiota and Obesity: The Chicken or the Egg?
Tassoni, D. S., Macedo, R. C. O., Delpino, F. M., & Santos, H. O. (2023) · Obesities · doi:10.3390/obesities3040024 · Cited by 16 · see citing works
Gut microbiota-metabolite interactions meditate the effect of dietary patterns on precocious puberty
Wang, Y., Jin, C., Li, H., Liang, X., Zhao, C., Wu, N., Yue, M., Zhao, L., Han, Y., Wang, Q., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109887 · Cited by 16 · see citing works
Type I Interferons as Joint Regulators of Tumor Growth and Obesity
Gessani, S., & Belardelli, F. (2021) · Cancers · doi:10.3390/cancers13020196 · Cited by 15 · see citing works
Mirizzi, A., Aballay, L. R., Misciagna, G., Caruso, M. G., Bonfiglio, C., Sorino, P., Bianco, A., Campanella, A., Franco, I., Curci, R., et al. (2021) · Nutrients · doi:10.3390/nu13114002 · Cited by 13 · see citing works
Blottière, H. M., & Dore, J. M. (2016) · médecine/sciences · doi:10.1051/medsci/20163211009 · Cited by 12 · see citing works
High-fat meal, systemic inflammation and glucose homeostasis in obese children and adolescents
Morandi, A., Fornari, E., Opri, F., Corradi, M., Tommasi, M., Bonadonna, R. C., & Maffeis, C. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.48 · Cited by 11 · see citing works
Ma, S., Zhu, J. L., Xie, S., Chen, R., Li, X., & Wei, W. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.08.071 · Cited by 9 · see citing works
Towards improved pharmacotherapy in pulmonary arterial hypertension. Can diet play a role?
Semen, K. O., & Bast, A. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.12.087 · Cited by 9 · see citing works
The Yin-Yang Concept of Pediatric Obesity and Gut Microbiota
Meliţ, L. E., Mărginean, C. O., & Săsăran, M. O. (2022) · Biomedicines · doi:10.3390/biomedicines10030645 · Cited by 9 · see citing works
Backer, V., Baines, K. J., Powell, H. A., Porsbjerg, C. M., & Gibson, P. G. (2015) · Respiratory Medicine · doi:10.1016/j.rmed.2015.12.003 · Cited by 9 · see citing works
Tabrizi, F. P. F., & Farhangi, M. A. (2021) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2021.06.003 · Cited by 8 · see citing works
Does total antioxidant capacity affect the features of metabolic syndrome? A systematic review
Rasaee, S., Alizadeh, M., Kheirouri, S., & Abdollahzad, H. (2020) · Nutrition & Food Science · doi:10.1108/nfs-01-2020-0031 · Cited by 8 · see citing works
Diet Quality, Obesity and Breast Cancer Risk: An Epidemiologic Study in Córdoba, Argentina
Coquet, J. B., Caballero, V. R., Camisasso, M. C., González, M. F., Niclis, C., Román, M. D., Muñoz, S. E., Leone, C. M., Procino, F., Osella, A. R., et al. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1664601 · Cited by 8 · see citing works
The effect of surgical fecal stream diversion of the healthy colon on the colonic microbiota
van der Sluis, W. B., Bouman, M., Mullender, M. G., Degen, M. C., Savelkoul, P. H. M., Meijerink, W. J. H. J., de Boer, N. K. H., Bodegraven, A. A. V., & Budding, A. E. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001330 · Cited by 7 · see citing works
Peng, D., Wang, Y., Yao, Y., Yang, Z., Wu, S., Zeng, K., Hu, X., & Zhao, Y. D. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04904-y · Cited by 8 · see citing works
De la dysfonction du tissu adipeux blanc aux phénotypes anatomocliniques de l’obésité
Ziegler, O., Böhme, P., & Valet, P. (2017) · Obésité · doi:10.1007/s11690-017-0555-z · Cited by 7 · see citing works
Bissonnette, N., Jiang, X., Matte, J. J., Guay, F., Talbot, G., Bontempo, V., Gong, J., Wang, Q., & Lessard, M. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.10.004 · Cited by 7 · see citing works
Dietary Patterns and Healthy Aging
Schoufour, J. D., Voortman, T., Franco, O. H., & Jong, J. C. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100348-0.00011-1 · Cited by 7 · see citing works
Bubnov, R. V., & NIa, S. (2018) · Preprints.org · doi:10.20944/preprints201809.0185.v1 · Cited by 6 · see citing works
Multimodal (Bio)Markers and Risk of Obesity – A Comprehensive Scoping Review
Vahid, F., Loyola-Leyva, A., Tur, J. A., Bouzas, C., Devaux, Y., Malisoux, L., García-Hernández, S., Carvalho, M. D., Ródenas-Munar, M., Turner, J., et al. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100579 · Cited by 5 · see citing works
Microbiote intestinal : qu’en attendre au plan physiologique et thérapeutique ?
Dore, J. M., Multon, M.-C., Béhier, J., Affagard, H., Andremont, A., Barthélémy, P., Batista, R., Bonneville, M., Bonny, C., Boyaval, G., et al. (2017) · Therapies · doi:10.1016/j.therap.2017.01.001 · Cited by 5 · see citing works
- Authors
- Kong, L. C., Holmes, B. A., Cotillard, A., Habi-Rachedi, F., Brazeilles, R., Gougis, S., Gausserès, N., Cani, P. D., Fellahi, S., Bastard, J.-P., Kennedy, S. P., Doré, J., Ehrlich, S. D., Zucker, J.-D., Rizkalla, S. W., & Clément, K.
- Affiliations
- Inserm (FR)
- Danone (France) (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Microbiologie de l’alimentation au service de la santé (FR)
- Corresponding author
- Rizkalla, Salwa W.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-10-20
- Volume
- 9
- Issue
- 10
- Pages
- e109434
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4203727
- OpenAlex
- W2014388281
- Cited by
- 132
- References
- 40
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 11 · 2023: 11 · 2022: 5 · 2021: 14 · 2020: 8 · 2019: 15 · 2018: 10 · 2017: 24 · 2016: 16 · 2015: 11 · 2014: 1
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion, cc-by)
- Digital Access to Libraries (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Danone
- European Commission (305312, 201052)
- Agence Nationale de la Recherche (ANR-10, ANR-10-IAHU-05)
- Fonds De La Recherche Scientifique - FNRS
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- dietary habits, obesity, overweight, gut microbiota, systemic inflammation, soluble CD14, CD163+ macrophages, adipose tissue, insulin sensitivity, interleukin-6, healthy eating habits, fruit and vegetable intake, sugar-sweetened beverages
- MeSH terms
- Adipose Tissue, Adult, Aged, Diet, Eating, Feces, Female, Humans, Inflammation, Intestines, Male, Middle Aged, Obesity, Cohort Studies, Biomarkers, Case-Control Studies, Polymerase Chain Reaction, High-Throughput Nucleotide Sequencing, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
