Omega-3 Fatty Acid Supplementation for 12 Weeks Increases Resting and Exercise Metabolic Rate in Healthy Community-Dwelling Older Females
Open accessAbstract
Critical among the changes that occur with aging are decreases in muscle mass and metabolic rate and an increase in fat mass. These changes may predispose older adults to chronic disease and functional impairment; ultimately resulting in a decrease in the quality of life. Research has suggested that long chain omega-3 fatty acids, found predominantly in fatty fish, may assist in reducing these changes. The objective of this study was to evaluate the effect of fish oil (FO) supplementation in a cohort of healthy, community-dwelling older females on 1) metabolic rate and substrate oxidation at rest and during exercise; 2) resting blood pressure and resting and exercise heart rates; 3) body composition; 4) strength and physical function, and; 5) blood measures of insulin, glucose, c-reactive protein, and triglycerides. Twenty-four females (66 ± 1 yr) were recruited and randomly assigned to receive either 3g/d of EPA and DHA or a placebo (PL, olive oil) for 12 wk. Exercise measurements were taken before and after 12 wk of supplementation and resting metabolic measures were made before and at 6 and 12 wk of supplementation. The results demonstrated that FO supplementation significantly increased resting metabolic rate by 14%, energy expenditure during exercise by 10%, and the rate of fat oxidation during rest by 19% and during exercise by 27%. In addition, FO consumption lowered triglyceride levels by 29% and increased lean mass by 4% and functional capacity by 7%, while no changes occurred in the PL group. In conclusion, FO may be a strategy to improve age-related physical and metabolic changes in healthy older females. Trial registration: ClinicalTrials.gov NCT01734538.
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“For example, studies like Logan et al. (2015) [21] and Hlavat ý et al. (2008) [16] specifically investigated female populations, often targeting post-menopausal women.”
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- Authors
- Logan, S. L., & Spriet, L. L.
- Affiliations
- University of Guelph (CA)
- Corresponding author
- Logan, Samantha L.
- ORCID
- Spriet, Lawrence L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-12-17
- Volume
- 10
- Issue
- 12
- Pages
- e0144828
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4682991
- OpenAlex
- W2217782636
- Cited by
- 155
- References
- 60
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 8 · 2023: 16 · 2022: 18 · 2021: 23 · 2020: 24 · 2019: 16 · 2018: 12 · 2017: 9 · 2016: 7 · 2014: 1
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- University of Guelph
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- omega-3 fatty acids, fish oil supplementation, EPA, docosahexaenoic acid, resting metabolic rate, substrate oxidation, fat oxidation, energy expenditure, older women, aging, body composition, lean body mass, functional capacity, blood pressure, heart rate, triglycerides, insulin, C-reactive protein, olive oil placebo
- MeSH terms
- Aged, Basal Metabolism, Blood Pressure, Female, Humans, Middle Aged, Exercise, Fatty Acids, Omega-3, Single-Blind Method, Dietary Supplements, Independent Living
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