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Cited by 56Mangiferin and Mango ExtractsSkin Protection and AgingAdvancements in Transdermal Drug Delivery

The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes

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Ochocka, Renata, Hering, Anna, Stefanowicz–Hajduk, Justyna, Cal, Krzysztof, Barańska, Helena·2017·PLOS ONE
DOI 10.1371/journal.pone.0181542PMC PMC5531637
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Abstract

Mangiferin (2-C-β-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a polyphenol with strong antioxidant properties. Mangiferin is obtained from the mango tree (Mangifera indica L., Anacardiaceae). It has been proven that mangiferin exhibits many pharmacological activities. The aim of this study was to analyze the penetration of mangiferin into the human skin and through the skin. According to our knowledge, skin penetration and permeation studies of mangiferin have not been analyzed so far. Additionally, the influence of mangiferin on two Extracellular Matrix Enzymes (ECM): collagenase and elastase, was evaluated for the first time. It has been indicated that mangiferin is able to permeate the stratum corneum and penetrate into the epidermis and dermis in comparable amounts. For confirmation of the obtained results, fluorescence microscopy was successfully utilized. The analysis revealed the capability of mangiferin to reversibly inhibit elastase and collagenase activity. The mechanism of mangiferin interaction with both enzymes was estimated as a noncompetitive inhibition.

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  • Mangiferin permeates the stratum corneum and passes into the epidermis and dermis.

    “Research has revealed the ability of mangiferin to reversibly inhibit elastase and collagenase activity, as well as to permeate the stratum corneum and pass into the epidermis and dermis (115).”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [115]

  • Mangiferin reversibly inhibits collagenase activity.

    “Research has revealed the ability of mangiferin to reversibly inhibit elastase and collagenase activity, as well as to permeate the stratum corneum and pass into the epidermis and dermis (115).”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [115]

  • Mangiferin reversibly inhibits elastase activity.

    “Research has revealed the ability of mangiferin to reversibly inhibit elastase and collagenase activity, as well as to permeate the stratum corneum and pass into the epidermis and dermis (115).”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [115]

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Cited by

Sorted by citations

Authors
Ochocka, R., Hering, A., Stefanowicz–Hajduk, J., Cal, K., & Barańska, H.
Affiliations
Gdańsk Medical University (PL)
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2017-07-27
Volume
12
Issue
7
Pages
e0181542
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0181542
PMC
PMC5531637
OpenAlex
W2741078826
Cited by
56
References
3
Citations by year
2026: 5 · 2025: 3 · 2024: 8 · 2023: 14 · 2022: 9 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 2
FWCI
4.46
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Research Centre
  • Krajowy Naukowy Osrodek Wiodacy
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
mangiferin, skin penetration, skin permeation, stratum corneum, collagenase inhibition, elastase inhibition, non-competitive inhibition, antioxidants, topical drug delivery
MeSH terms
Adult, Enzyme Inhibitors, Extracellular Matrix, Humans, Kinetics, Middle Aged, Pancreatic Elastase, Skin, Skin Absorption, Solutions, Collagenases, Xanthones

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