Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines
Open accessAbstract
Meteorin-like (Metrnl) is a newly discovered adipokine with favorable effect on insulin sensitivity. Previous studies have reported lower levels of Metrnl in obese patients. However, there is conflicting data regarding its circulating levels in type 2 diabetes mellitus (T2DM) and there is no data in patients with coronary artery disease (CAD). The aim of the present study was to evaluate the Metrnl serum level in patients with T2DM and CAD, and also to evaluate the serum levels of Metrnl with serum levels of adiponectin, IL-6 and TNF-α in patients. This study was conducted on 66 patients with CAD, 63 T2DM patients and 41 controls. The serum levels of Metrnl, adiponectin, IL-6 and TNF-α were measured using ELISA techniques. The serum levels of Metrnl were found to be lower in CAD (75.18 ± 28.48 pg/mL) and T2DM patients (73.89 ± 33.60 pg/mL) compared to the control group (95.33 ± 32.56 pg/mL) (p < 0.005 and p<0.003, respectively). Additionally, adiponectin decreased in CAD and T2DM patients as compared to the control group, while IL-6 and TNF-α were higher in CAD and T2DM patients. Metrnl showed independent association with the risk of CAD and T2DM presence. Furthermore, Metrnl illustrated a negative correlation with IL-6 and TNF-α in both CAD patients and also with BMI, insulin resistance, IL-6 and TNF-α in T2DM patients. Metrnl showed an association with CAD and T2DM presence and with components of their pathogenesis such as inflammation and insulin resistance. These results suggested a possible interaction between Metrnl and the pathogenesis of CAD and T2DM, however more studies are needed to prove this concept.
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Metrnl levels are implicated in the trajectory of atherosclerosis, serving as an independent prognostic marker for disease progression.
“Furthermore, Metrnl levels are implicated in the trajectory of atherosclerosis, serving as an independent prognostic marker for disease progression [72,73].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [73]
The Results section ('Association of Metrnl with CAD and T2DM'; page unavailable) reports that lower Metrnl levels were associated with CAD presence after adjustment for age, sex, and BMI. But the Methods describe a cross-sectional study, and the Discussion cautions that its design limits causal conclusions. The paper does not establish Metrnl as a prognostic marker of atherosclerosis progression. (LLM, conf=0.89)
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Sıçanlarda APAP Kaynaklı Toksisitede EKG, Oksidatif Stres ve Anjiyogenezin Belirlenmesi
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Meteorin-Like ve Metabolik Etkileri
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- Authors
- Dadmanesh, M., Aghajani, H., Fadaei, R., & Ghorban, K.
- Affiliations
- Aja University of Medical Sciences (IR)
- Tehran Heart Center (IR)
- Corresponding author
- Fadaei, Reza
- Ghorban, Khodayar
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-09-13
- Volume
- 13
- Issue
- 9
- Pages
- e0204180
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6136801
- OpenAlex
- W2890563523
- Cited by
- 89
- References
- 31
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 14 · 2023: 7 · 2022: 12 · 2021: 8 · 2020: 13 · 2019: 5
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tehran Heart Center
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- meteorin-like, coronary artery disease, type 2 diabetes, insulin resistance, adiponectin, interleukin-6, TNF-α, inflammatory cytokines, adipokines, obesity, body mass index
- MeSH terms
- Aged, Blood Glucose, Coronary Artery Disease, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Insulin Resistance, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Tumor Necrosis Factor-alpha, Interleukin-6, Gene Expression, Case-Control Studies, Adiponectin, Adipokines
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