Serum Metrnl is associated with the presence and severity of coronary artery disease
Open accessAbstract
Meteorin-like (Metrnl) is a novel adipokine that is highly expressed in white adipose tissue. Metrnl stimulates energy expenditure and improves glucose tolerance in rodents. However, whether Metrnl plays a role in coronary artery disease (CAD) remains to be elucidated. The present study aimed to investigate the association of serum Metrnl with CAD in Chinese patients. A total of 193 patients with CAD and 156 control subjects were enrolled in this study. Serum Metrnl concentration was measured by enzyme-linked immunosorbent assay. Anthropometric phenotypes, fasting glucose, serum lipids, and inflammatory cytokines were measured. Serum Metrnl was lower in CAD patients when compared to those controls (132.41 vs 173.17 pg/mL, P < 0.001). Serum Metrnl was negatively correlated with metabolic parameters, including body mass index, total cholesterol, and low-density lipoprotein cholesterol as well as inflammatory markers including high-sensitivity C-reactive protein, IL-1β, and IL-11 even after adjustment for potential confounding variables (P < 0.05). In multivariable logistic regression analyses, compared to those in the highest tertile of serum Metrnl levels, subjects in the lowest tertile had the highest risks for CAD (adjusted OR = 2.63, 95% CI = 1.46-4.27, P = 0.001). After adjustment for potential confounding variables, serum Metrnl was also decreased as the number of stenosed vessels increased (P < 0.001). Furthermore, decreased Metrnl level was negatively correlated with the severity of CAD quantified by the Gensini score. This first case-control study shows significant associations of serum Metrnl with the presence and severity of CAD, suggesting Metrnl might be a new promising therapeutic target for CAD.
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Circulating Metrnl levels are diminished in patients suffering acute myocardial infarction, where lower concentrations correlate with greater disease severity and heightened long-term risk.
“Clinically, its circulating levels are diminished in patients suffering acute myocardial infarction, where lower concentrations correlate with greater disease severity and heightened long-term risk [72].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [72]
The Results section reports decreased serum Metrnl in patients with acute myocardial infarction and an inverse correlation with coronary artery disease severity, measured across CAD patients. It does not establish that severity correlation specifically within the infarction subgroup. The Discussion describes the study as cross-sectional, so it does not support the claim of heightened long-term risk. (LLM, conf=0.89)
Experimental — accuracy not yet measuredMetrnl levels are implicated in the trajectory of atherosclerosis, serving as an independent prognostic marker for disease progression.
“Furthermore, Metrnl levels are implicated in the trajectory of atherosclerosis, serving as an independent prognostic marker for disease progression [72,73].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [72]
The Results report that serum Metrnl was associated with CAD presence after adjustment for potential confounders and was inversely correlated with CAD severity. But the Discussion identifies the study as cross-sectional and says the proposed role of Metrnl in atherosclerosis needs further study. The paper does not establish Metrnl as a prognostic marker of disease progression over time. (LLM, conf=0.90)
Experimental — accuracy not yet measured
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Cites
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Third universal definition of myocardial infarction
the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., CHAITMAN, B. R., & White, H. D. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.122 · Cited by 6,583 · see citing works
Third Universal Definition of Myocardial Infarction
Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., & White, H. D. (2012) · Circulation · doi:10.1161/cir.0b013e31826e1058 · Cited by 2,985 · see citing works
A more meaningful scoring system for determining the severity of coronary heart disease
Gensini, G. G. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80105-2 · Cited by 2,171 · see citing works
Insulin Resistance, Hyperglycemia, and Atherosclerosis
Bornfeldt, K., & Tabas, I. A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.015 · Cited by 1,002 · see citing works
Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.065 · Cited by 973 · see citing works
Adipose tissue in control of metabolism
Luo, L., & Liu, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0211 · Cited by 708 · see citing works
Adipocyte metrnl antagonizes insulin resistance through PPARγ signaling
Li, Z.-Y., Song, J., Zheng, S.-L., Fan, M.-B., Guan, Y.-F., Qu, Y., Xu, J., Wang, P., & Miao, C.-Y. (2015) · Diabetes · doi:10.2337/db15-0274 · Cited by 203 · see citing works
Metrnl: A secreted protein with new emerging functions
Zheng, S.-L., Li, Z.-Y., Song, J., Liu, J.-M., & Miao, C.-Y. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.9 · Cited by 190 · see citing works
METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages
Ushach, I., Burkhardt, A. M., Martinez, C., Hevezi, P. A., Gerber, P. A., Buhren, B. A., Schrumpf, H., Valle‐Rios, R., Vazquez, M. I., Homey, B., et al. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.11.006 · Cited by 155 · see citing works
Macrophage metabolism in atherosclerosis
Bories, G. F. P., & Leitinger, N. (2017) · FEBS Letters · doi:10.1002/1873-3468.12786 · Cited by 145 · see citing works
Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression
Li, Z., Zheng, S., Wang, P., Xu, T., Guan, Y., Zhang, Y., & Miao, C. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12219 · Cited by 131 · see citing works
Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes
Chung, H. S., Hwang, S. Y., Choi, J. H., Lee, H. J., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.11.031 · Cited by 96 · see citing works
The role of adipokines in cardiovascular disease
Shibata, R., Ouchi, N., Ohashi, K., & Murohara, T. (2017) · Journal of Cardiology · doi:10.1016/j.jjcc.2017.02.006 · Cited by 93 · see citing works
DeBoer, M. D., Gurka, M. J., Golden, S. H., Musani, S. K., Sims, M., Vishnu, A., Guo, Y. M., & Pearson, T. A. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.10.088 · Cited by 88 · see citing works
Jørgensen, J. R., Fransson, A., Fjord‐Larsen, L., Thompson, L. H., Houchins, J. P., Andrade, N., Torp, M., Kalkkinen, N., Andersson, E., Lindvall, O., et al. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.027 · Cited by 87 · see citing works
Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes
Lee, J. H., Kang, Y. E., Kim, J. M., Choung, S., Joung, K. H., Kim, H. J., & Ku, B. J. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.10.005 · Cited by 75 · see citing works
Löffler, D., Landgraf, K., Rockstroh, D., Schwartze, J. T., Dunzendorfer, H., Kiess, W., & Körner, A. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.180 · Cited by 61 · see citing works
Impact of the cardiovascular system-associated adipose tissue on atherosclerotic pathology
Chistiakov, D. A., Grechko, A. V., Myasoedova, V. A., Melnichenko, A. А., & Orekhov, A. N. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.06.017 · Cited by 53 · see citing works
Pellitero, S., Piquer‐Garcia, I., Ferrer‐Curriu, G., Puig, R., Martínez, E., Moreno, P., Tarascó, J., Balibrea, J. M., Lerín, C., Puig‐Domingo, M., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.268 · Cited by 52 · see citing works
Wang, L., Yan, J.-J., Tang, N., Zhu, J., Wang, Y., Wang, Q., Tang, J.-J., Wang, M., Jia, E., Yang, Z., et al. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0171-6 · Cited by 31 · see citing works
Self-citationKoleva, D. I., Orbetzova, M. M., Nikolova, J. G., & Deneva, T. (2016) · Folia Medica · doi:10.1515/folmed-2016-0039 · Cited by 25 · see citing works
Leptin in Thrombosis and Atherosclerosis
Wang, H., Luo, W., & Eitzman, D. T. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990015 · Cited by 23 · see citing works
Leptin, leptin soluble receptor and coronary atherosclerosis
Hoefle, G., Saely, C. H., Risch, L., Rein, P., Koch, L., Schmid, F. M., Aczél, S., Marte, T., Langer, P. H., & Drexel, H. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01842.x · Cited by 18 · see citing works
Liu, Z., Zhang, M., Wu, J. S., Zhou, P., Liu, Y., Wu, Y., Yang, Y., & Lü, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131086 · Cited by 17 · see citing works
Self-citationWang, Y., Gao, W. Q., Li, H., Wang, Z., Zhu, J., Zhao, H., Yan, J., Jia, E., Yang, Z., & Wang, L. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1184-8 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Hu, C., Zhang, X., Song, P. K., Yuan, Y., Kong, C., Wu, H., Xu, S., Ma, Z., & Tang, Q. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101747 · Cited by 243 · see citing works
Liu, J., Jia, S., Yang, Y., Piao, L., Wang, Z., Jin, Z., & Bai, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114118 · Cited by 176 · see citing works
Adipokines and Inflammation: Focus on Cardiovascular Diseases
Feijóo‐Bandín, S., Aragón‐Herrera, A., Moraña‐Fernández, S., Anido‐Varela, L., Tarazón, E., Roselló‐Lletí, E., Portolés, M., Moscoso, I., Gualillo, O., González‐Juanatey, J. R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207711 · Cited by 123 · see citing works
Li, Z., Gao, Z., Sun, T., Zhang, S., Yang, S., Zheng, M., & Shen, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098570 · Cited by 97 · see citing works
El‐Ashmawy, H. M., Selim, F. O., Hosny, T., & Almassry, H. N. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.02.026 · Cited by 93 · see citing works
Involvement of the secreted protein Metrnl in human diseases
Miao, Z., Hu, W., Li, Z., & Miao, C. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00529-9 · Cited by 84 · see citing works
Meteorin-like/Meteorin-β protects heart against cardiac dysfunction
Rupérez, C., Ferrer‐Curriu, G., Cervera-Barea, A., Florit, L., Guitart‐Mampel, M., Garrabou, G., Zamora, M., Crispi, F., Fernández‐Solà, J., Lupón, J., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201206 · Cited by 79 · see citing works
Meteorin-like protein (Metrnl): A metabolic syndrome biomarker and an exercise mediator
Alizadeh, H. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155952 · Cited by 57 · see citing works
Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study
Fouani, F. Z., Fadaei, R., Moradi, N., Zandieh, Z., Ansaripour, S., Yekaninejad, M. S., Vatannejad, A., & Mahmoudi, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231943 · Cited by 50 · see citing works
Du, Y., Ye, X., Lu, A., Zhao, D., Liu, J., Cheng, J., & Yang, T. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108068 · Cited by 49 · see citing works
Zheng, S., Li, Z., Song, J., Wang, P., Xu, J., Hu, W., Shi, Y., Qi, Q., Miao, Z., Guan, Y., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.008 · Cited by 48 · see citing works
Chen, X., Chen, X., Yang, Y., Luo, N., Yang, J., Zhong, L., Guo, T., Yuan, Z., Wei, Q., & Wang, C. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109690 · Cited by 45 · see citing works
Ding, X., Chang, X., Wang, J., Bian, N., An, Y., Wang, G., & Liu, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.938341 · Cited by 43 · see citing works
Shero, J. A., Lindholm, M. E., Sandri, M. F., & Stanford, K. I. (2025) · Circulation Research · doi:10.1161/circresaha.124.325614 · Cited by 43 · see citing works
Cai, J., Wang, Q., Li, J., Xu, F., Bu, Y., Wang, M., Lü, X., & Gao, W. Q. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12865 · Cited by 38 · see citing works
Self-citationMeteorin-Like Protein (Metrnl) in Obesity, during Weight Loss and in Adipocyte Differentiation
Schmid, A., Karrasch, T., & Schäffler, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194338 · Cited by 34 · see citing works
Metrnl: a promising biomarker and therapeutic target for cardiovascular and metabolic diseases
Dong, W.-S., Hu, C., Hu, M., Gao, Y.-P., Hu, Y.-X., Li, K., Ye, Y.-J., & Zhang, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01767-8 · Cited by 27 · see citing works
Is Metrnl an Adipokine İnvolved in the Anti-inflammatory Response to Acute Exacerbations of COPD?
Kerget, B., Afşin, D. E., Kerget, F., Aşkın, S., & Akgün, M. (2020) · Lung · doi:10.1007/s00408-020-00327-4 · Cited by 29 · see citing works
Sobieh, B. H., Kassem, D. H., Zakaria, Z. M., & EL-Mesallamy, H. O. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155368 · Cited by 29 · see citing works
Liu, J., Diao, L., Xia, W., Zeng, X., Li, W., Zou, J., Liu, T., Pang, X., & Wang, Y. (2023) · Aging · doi:10.18632/aging.205268 · Cited by 28 · see citing works
Self-citationDu, Y.-N., Teng, J., Zhou, T., Du, B.-Y., & Cai, W. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01049-4 · Cited by 27 · see citing works
Correlation of serum meteorin-like concentrations with diabetic nephropathy
Wang, R., Hu, D., Zhao, X., & Hu, W. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108443 · Cited by 26 · see citing works
Decreased serum interleukin‐41/Metrnl levels in patients with Graves' disease
Gong, L., Huang, G., Weng, L., Xu, J., Li, Y., Cui, W., & Li, M. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24676 · Cited by 25 · see citing works
Metrnl as a secreted protein: Discovery and cardiovascular research
Miao, Z., Chen, J., Chen, C.-X., Zheng, S., Zhao, H., & Miao, C. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108730 · Cited by 24 · see citing works
The role of adipokines in osteoporosis management: a mini review
Patil, J. D., & Fredericks, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1336543 · Cited by 23 · see citing works
Elevated levels of Metrnl in rheumatoid arthritis: Association with disease activity
Zhang, S., Lei, Y., Sun, T., Gao, Z., Li, Z., & Shen, H. (2022) · Cytokine · doi:10.1016/j.cyto.2022.156026 · Cited by 22 · see citing works
Myokine-mediated exercise effects: the role of myokine meteorin-like hormone (Metrnl)
Alizadeh, H. (2021) · Growth Factors · doi:10.1080/08977194.2022.2032689 · Cited by 20 · see citing works
Si, Y., Feng, Z., Liu, Y., Fan, W., Shan, W., Zhang, Y., Shi, F., Xing, E., & Sun, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-30035-x · Cited by 20 · see citing works
Self-citationFerns, G. A., Fekri, K., Abadi, M. S. S., Dehkordi, M. B., & Arjmand, M.-H. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1899239 · Cited by 20 · see citing works
Human Cytomegalovirus Infection and Cardiovascular Disease: Current Perspectives
Lee, S., Affandi, J. S., Waters, S., & Price, P. (2023) · Viral Immunology · doi:10.1089/vim.2022.0139 · Cited by 18 · see citing works
The blooming intersection of subfatin and metabolic syndrome
Huang, S., Cao, L., Cheng, H., Li, D., Li, Y. W., & Wu, Z. (2021) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2203086 · Cited by 15 · see citing works
Liu, M., Gao, X., Tian, Y., Li, H., Yin, Z., Han, L., & Zhang, L. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s447127 · Cited by 15 · see citing works
Han, R., Huang, H., Zhu, J., Jin, X., Wang, Y., Xu, Y., & Xia, Z. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02357-w · Cited by 15 · see citing works
Self-citationRole of circulating molecules in age-related cardiovascular and metabolic disorders
Hsiao, Y., Shimizu, I., Yoshida, Y., & Minamino, T. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-021-00187-2 · Cited by 15 · see citing works
Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients
Miao, Z., Wang, N., Hu, W., Zheng, S., Wang, D., Chang, F.-Q., Wang, Z., Tian, J., Dong, X., Wu, T., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01204-5 · Cited by 14 · see citing works
Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases
Lyu, J.-X., Guo, D., Song, Y.-C., Zhang, M.-R., Ge, F.-Q., Zhao, J., Zhu, H., & Hang, P. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2502056 · Cited by 13 · see citing works
Liu, N., Dong, J., Li, L., Zhou, D., & Liu, F. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s455790 · Cited by 13 · see citing works
Meteorin-like protein (Metrnl): a key exerkine in exercise-mediated cardiovascular health
Alizadeh, H., Parsaeifar, A., & Mirzaei, R. M. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2497272 · Cited by 12 · see citing works
Plasma interleukin-41 serves as a potential diagnostic biomarker for Kawasaki disease
Cai, X., Li, K., Li, M., Lu, Y., Wu, J., Qiu, H., & Li, Y. J. (2023) · Microvascular Research · doi:10.1016/j.mvr.2023.104478 · Cited by 11 · see citing works
Ferrer‐Curriu, G., Rueda, F., Revuelta‐López, E., García‐García, C., Codina, P., Gálvez‐Montón, C., Roura, S., Aimo, A., Emdin, M., Planavila, A., et al. (2023) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2023.03.015 · Cited by 11 · see citing works
Roles and mechanism of IL-11 in vascular diseases
Wu, J., Ma, W., Qiu, Z., & Zhou, Z. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1171697 · Cited by 10 · see citing works
Homotherapy for heteropathy: Interleukin‐41 and its biological functions
Shi, R., He, M., Peng, Y., & Xu, X. (2024) · Immunology · doi:10.1111/imm.13791 · Cited by 10 · see citing works
Serum IL-41 might be a biomarker for IVIG resistance and coronary artery lesions in Kawasaki disease
Duan, Y., Li, H., Luo, D., Jiang, J., Li, G., & Li, G. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110600 · Cited by 10 · see citing works
Low Levels of Metrnl are Linked to the Deterioration of Diabetic Kidney Disease
Chen, J., Li, Z., Xu, F., Wang, C., Li, W., Lu, J., & Miao, C. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s452055 · Cited by 9 · see citing works
The Meteorin-like cytokine is upregulated in grass carp after infection with Aeromonas hydrophila
Jia, Z., Feng, J., Yuan, G., Xiao, H., Dang, H., Zhang, Y., Chen, K., Zou, J., & Wang, J. (2023) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2023.104632 · Cited by 9 · see citing works
Zhou, L., Long, H., & Alizadeh, H. (2025) · Obesity Reviews · doi:10.1111/obr.70046 · Cited by 8 · see citing works
Meteorin-β: A Novel Biomarker and Therapeutic Target on Its Way to the Regulation of Human Diseases
Wang, B., Xiao, L., & Gao, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104485 · Cited by 8 · see citing works
The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in Diffuse Systemic Sclerosis
Freedman, P., Schock, B. C., & O’Reilly, S. (2024) · Cells · doi:10.3390/cells13141205 · Cited by 7 · see citing works
Zhou, C., Zeng, J., Gao, X., Chen, D., Zhu, Q., Feng, B., & Song, J. H. (2024) · PeerJ · doi:10.7717/peerj.18264 · Cited by 7 · see citing works
Subfatin concentration decreases in acute coronary syndrome
Yilmaz, M., Goktekin, M. C., & İlhan, N. (2022) · Biochemia Medica · doi:10.11613/bm.2022.020704 · Cited by 7 · see citing works
Potential clinical value of serum interleukin-41 levels in patients with acute gout
Zhou, Y., Shi, S., Meng, S., Zhao, H., Wu, X., Li, M., & Li, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110621 · Cited by 7 · see citing works
Luteolin Inhibits Ferroptosis of HUVEC by Regulating the Sirt1/Nrf2 Pathway
Xiang, M., Lin, X., & Chen, H. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01831-1 · Cited by 6 · see citing works
Xu, C., Jiang, X., Hou, S., Lai, F., Hu, K., Li, J., Yang, T., Shen, X., Chen, H., Chen, S., et al. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156459 · Cited by 6 · see citing works
Low serum Metrnl levels are associated with increased risk of sarcopenia in the older adults
Wang, Z., Li, Y., Yan, J.-J., Wang, Q., Zhao, C., Lu, X., Shen, Z., Xu, J., & Gao, W. Q. (2024) · European Geriatric Medicine · doi:10.1007/s41999-024-01074-y · Cited by 6 · see citing works
Self-citationFerrer‐Curriu, G., Rueda, F., Revuelta‐López, E., García‐García, C., Codina, P., Gálvez‐Montón, C., Roura, S., Aimo, A., Emdin, M., Planavila, A., et al. (2023) · Revista Española de Cardiología · doi:10.1016/j.recesp.2023.03.016 · Cited by 5 · see citing works
Khajebishak, Y., Faghfouri, A. H., Soleimani, A., Madani, S., & Payahoo, L. (2022) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2022-0037 · Cited by 5 · see citing works
Liu, M., Liu, Z., Zhu, H., Wang, L., Yang, H., Yan, K., Gong, F., Pan, H., & Zeng, Y. (2020) · International Journal of Endocrinology · doi:10.1155/2020/7864721 · Cited by 5 · see citing works
Self-citationLi, J., Ye, P., Si, J., & Xiang, G. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.12.003 · Cited by 4 · see citing works
Wang, D.-X., Wang, P., Miao, Z., Wang, S.-N., Zheng, S.-L., Wang, X.-L., Li, J., Li, Z.-Y., Chen, Y., Zhang, T.-G., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108123 · Cited by 4 · see citing works
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Zhao, J., Li, X., Liang, C., & Yan, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051790 · Cited by 4 · see citing works
Alizadeh, H., & Safarzade, A. (2025) · Sport Sciences for Health · doi:10.1007/s11332-025-01350-9 · Cited by 3 · see citing works
Zhang, Y., & Qiu, Y. (2026) · Sports · doi:10.3390/sports14050212 · Cited by 3 · see citing works
Unveiling IL-41: A novel biomarker for polymyositis and dermatomyositis diagnosis
Li, Z., Qin, W., Wu, X., Li, M., & Li, Z. (2025) · Cytokine · doi:10.1016/j.cyto.2025.157058 · Cited by 3 · see citing works
Deng, X., Yang, Z., Yu, Q., Wu, X., Sun, Z., Yang, L., & Yuan, G. (2026) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188261419199 · Cited by 3 · see citing works
Metrnl in health and disease: tissue-specific actions and signaling networks
Zhao, R., Qi, Y., Li, P., Zhang, Z., Chen, Y., Wu, X., Wang, W., Guo, X., Zhao, H., Yang, Y., et al. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02312-3 · Cited by 3 · see citing works
Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis
Lu, W., Li, Z., Shi, S., Meng, S., Pang, J., Li, M., & Li, M. (2025) · Future Science OA · doi:10.1080/20565623.2025.2545732 · Cited by 2 · see citing works
Li, Z., Li, M., & Li, Y. (2026) · Cytokine · doi:10.1016/j.cyto.2026.157125 · Cited by 2 · see citing works
Khajebishak, Y., Madani, S., Faghfouri, A. H., Soleimani, A., Ilaei, S., Peyrovi, S., & Payahoo, L. (2022) · Nutrition & Food Science · doi:10.1108/nfs-06-2022-0186 · Cited by 2 · see citing works
Saeidi, M., Mogharnasi, M., Afzalpour, M. E., Bijeh, N., & Vieira, A. (2023) · Science & Sports · doi:10.1016/j.scispo.2022.05.006 · Cited by 2 · see citing works
Azadi, S. M., Fadaei, R., Esmaeili, F., Poustchi, H., Radmard, A. R., Shayanrad, A., Emamgholipour, S., & Doosti, M. (2026) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2026.04.010 · Cited by 1 · see citing works
Miao, Z., Chen, C.-X., Wang, P., Zheng, S.-L., Jiang, J.-B., Hu, W.-J., Zhu, X., Lu, B., Chen, L., Hu, L., et al. (2026) · Circulation · doi:10.1161/circulationaha.126.077134 · Cited by 1 · see citing works
Więcek, M., Kantorowicz, M., Szymura, J., Kuśmierczyk, J., Lipowska, M., & Szyguła, Z. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27136019 · Cited by 1 · see citing works
Bi, K., Smolyakov, Y. N., Guseva, E. S., Давыдов, С. О., & Цыбиков, Н. Н. (2020) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2020-26-5-581-589
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Kaya, S., & Yalçın, T. (2023) · doi:10.59287/sbocc.309
Metrnl plays a crucial role in the regulation of glycolipid metabolism
Zhang, J., Wang, G., Wang, X., Liu, X., & Zhou, X. (2025) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2024.79
Myokines as biological markers in disorders of carbohydrate metabolism and atherosclerosis
Alieva, A. M., Baykova, I. E., Фатхуллаевна, А. М., Алмардонович, М. А., Булатовна, С. А., Rakhaev, A. M., Орусбиевич, А. А., Алимович, М. А., & Nikitin, I. G. (2025) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2025-015
Myokines — the cardiometabolic risk potential biomarkers
Timofeev, Y. S., Metelskaya, V. A., Sheptulina, A. F., Neshkova, E. A., Dubovskaya, N. I., Yafarova, A. A., Мамутовна, М. Э., Валерьевна, Д. Н., Khatri, D. N., & Drapkina, O. M. (2025) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202528071119
Ibrahim, A. Y., & Neamah, N. F. (2025) · Biomedical & Pharmacology Journal · doi:10.13005/10.13005/bpj/3265
Chen, J., Lin, J., Zhao, W., Xue, X., Lü, X., & Sun, C. (2025) · Research Square · doi:10.21203/rs.3.rs-8015709/v1
Tosun, F., Bayrak, G., Yılmaz, N., Doğukan, M., Duran, M., Koçak, S., & Bozkurt, Z. (2025) · Mersin üniversitesi sağlık bilimleri dergisi/Mersin üniversitesi sağlık bilimleri dergisi · doi:10.26559/mersinsbd.1711748
Cardiac immunity and heart repair: Mechanism, challenge, and future direction
Liu, Y., Ren, Q., Wang, H. T., Jiang, X., Zhao, M. H., Min, Q., Xie, Y., Cai, D., & Nie, Y. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004078
Self-citationMetrnl: A Novel Therapeutic Target in Atherosclerosis
Wang, P., Wang, D. F., & Miao, C. (2026) · iNew Medicine · doi:10.1002/inm3.70069
Meteorin-like (Metrnl): An emerging target linking metabolism, immunity, and tissue homeostasis
Feng, K., He, C., Xie, F., & Zhang, T. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.109647
- Authors
- Liu, Z., Ji, H., Yao, M., Wang, L., Wang, Y., Zhou, P., Liu, Y., Zheng, X., He, H., Wang, L., Gao, W., & Lu, X.
- Affiliations
- Department of Geriatrics The Affiliated Sir Run Run Hospital of Nanjing Medical University Nanjing China
- Department of Internal Medicine The Hospital of HoHai University Nanjing China
- Nanjing Medical University (CN)
- Jiangsu Province Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Corresponding author
- Gao, Wei
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2018-11-05
- Volume
- 23
- Issue
- 1
- Pages
- 271-280
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC6307872
- OpenAlex
- W2900362176
- Cited by
- 84
- References
- 26
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 13 · 2023: 16 · 2022: 10 · 2021: 6 · 2020: 10 · 2019: 1
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BK20171051)
- National Natural Science Foundation of China (81470501, 81700331, 81770440)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- meteorin-like, Metrnl, coronary artery disease, adipokines, serum biomarkers, disease severity, Gensini score, inflammatory cytokines, C-reactive protein, IL-1β, interleukin-11, dyslipidemia, white adipose tissue, therapeutic target
- MeSH terms
- Aged, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Biomarkers, Logistic Models, Case-Control Studies, Cytokines, Asian People, Adipokines
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