Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

Ali, Tahir; Yoon, Gwang Ho; Shah, Shahid Ali; Lee, Hae Young; Kim, Myeong Ok

doi:10.1038/srep11708

Cited by 146Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionDementia and Cognitive Impairment Research

Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

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Ali, Tahir, Yoon, Gwang Ho, Shah, Shahid Ali, Lee, Hae Young, Kim, Myeong Ok·2015·Scientific Reports

DOI 10.1038/srep11708PMC PMC4484370

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Abstract

The pathological hallmarks of Alzheimer's disease (AD) include amyloid beta (Aβ) accumulation, neurofibrillary tangle formation, synaptic dysfunction and neuronal loss. In this study, we investigated the neuroprotection of novel osmotin, a plant protein extracted from Nicotiana tabacum that has been considered to be a homolog of mammalian adiponectin. Here, we observed that treatment with osmotin (15 μg/g, intraperitoneally, 4 hr) at 3 and 40 days post-intracerebroventricular injection of Aβ1-42 significantly ameliorated Aβ1-42-induced memory impairment in mice. These results revealed that osmotin reverses Aβ1-42 injection-induced synaptic deficits, Aβ accumulation and BACE-1 expression. Treatment with osmotin also alleviated the Aβ1-42-induced hyperphosphorylation of the tau protein at serine 413 through the regulation of the aberrant phosphorylation of p-PI3K, p-Akt (serine 473) and p-GSK3β (serine 9). Moreover, our western blots and immunohistochemical results indicated that osmotin prevented Aβ1-42-induced apoptosis and neurodegeneration in the Aβ1-42-treated mice. Furthermore, osmotin attenuated Aβ1-42-induced neurotoxicity in vitro.To our knowledge, this study is the first to investigate the neuroprotective effect of a novel osmotin against Aβ1-42-induced neurotoxicity. Our results demonstrated that this ubiquitous plant protein could potentially serve as a novel, promising, and accessible neuroprotective agent against progressive neurodegenerative diseases such as AD.

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Osmotin has neuroprotective effects by preventing memory impairment and neuroinflammation induced by amyloid or LPS injections.
“Other studies have demonstrated its neuroprotective effects by preventing memory impairment and neuroinflammation induced by either amyloid or LPS injections [128,129].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [128]

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Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges
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Anthocyanin-Loaded PEG-Gold Nanoparticles Enhanced the Neuroprotection of Anthocyanins in an Aβ1–42 Mouse Model of Alzheimer’s Disease
Ali, T., Kim, M. J., Rehman, S. U., Ahmad, A., & Kim, M. O. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0136-4 · Cited by 138 · see citing works
Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases
Yeo, I. J., Lee, C., Han, S., Yun, J., & Hong, J. T. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107394 · Cited by 135 · see citing works
RETRACTED ARTICLE: Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice
Khan, M. S., Ali, T., Kim, M. W., Jo, M. H., Chung, J. I., & Kim, M. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1101-1 · Cited by 129 · see citing works
Retracted
Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex
Khan, M. S., Ali, T., Kim, M. W., Jo, M. H., Jo, M. G., Badshah, H., & Kim, M. O. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.005 · Cited by 124 · see citing works
Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer’s Disease-Like Condition in a Rat Model
Bhuvanendran, S., Kumari, Y., Othman, I., & Shaikh, M. F. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00665 · Cited by 120 · see citing works
Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer's disease
Amin, F. U., Hoshiar, A. K., Duc, T., Noh, Y., Shah, S. A., Khan, M. S., Yoon, J., & Kim, M. O. (2017) · Nanoscale · doi:10.1039/c7nr00772h · Cited by 119 · see citing works
Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway
Azimi, M., Gharakhanlou, R., Naghdi, N., Khodadadi, D., & Heysieattalab, S. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.027 · Cited by 109 · see citing works
The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
Jembrek, M. J., Slade, N., Hof, P. R., & Šimić, G. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.05.001 · Cited by 99 · see citing works
Does COVID‐19 contribute to development of neurological disease?
Mahalakshmi, A. M., Ray, B., Tuladhar, S., Bhat, A., Paneyala, S., Patteswari, D., Sakharkar, M. K., Hamdan, H., Ojcius, D. M., Bolla, S. R., et al. (2020) · Immunity Inflammation and Disease · doi:10.1002/iid3.387 · Cited by 100 · see citing works
Neuroprotective effects of INT-777 against Aβ1–42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice
Wu, X. G., Lv, Y., Du, Y., Chen, F., Reed, M. N., Hu, M. Y., Suppiramaniam, V. D., Tang, S., & Hong, H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.06.018 · Cited by 100 · see citing works
Possible Involvement of Adiponectin, the Anti-Diabetes Molecule, in the Pathogenesis of Alzheimer’s Disease
Waragai, M., Adame, A., Trinh, I., Sekiyama, K., Takamatsu, Y., Une, K., Masliah, E., & Hashimoto, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151116 · Cited by 82 · see citing works
Protective effects of linalool against amyloid beta-induced cognitive deficits and damages in mice
Xu, P., Wang, K., Lü, C., Dong, L., Gao, L., Yan, M., Aibai, S., Yang, Y., & Liu, X. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.010 · Cited by 77 · see citing works
Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse models
Ahmad, A., Ali, T., Kim, M. W., Khan, A., Jo, M. H., Rehman, S. U., Khan, M. S., Abid, N. B., Khan, M., Ullah, R., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2018.10.004 · Cited by 76 · see citing works
Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels
Khodadadi, D., Gharakhanlou, R., Naghdi, N., Salimi, M., Azimi, M., Shahed, A., & Heysieattalab, S. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2571-2 · Cited by 71 · see citing works
Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?
Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72 · see citing works
Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases
Liu, Y., Vu, V., & Sweeney, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00842 · Cited by 69 · see citing works
AdipoRon improves cognitive dysfunction of Alzheimer’s disease and rescues impaired neural stem cell proliferation through AdipoR1/AMPK pathway
Liu, B., Liu, J., Wang, J., Liu, C., & Yan, H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113249 · Cited by 67 · see citing works
Nanoparticle-Guided Brain Drug Delivery: Expanding the Therapeutic Approach to Neurodegenerative Diseases
Riccardi, C., Napolitano, F., Montesarchio, D., Sampaolo, S., & Melone, M. A. B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111897 · Cited by 66 · see citing works
Adiponectin-Mimetic Novel Nonapeptide Rescues Aberrant Neuronal Metabolic-Associated Memory Deficits in Alzheimer’s Disease
Ali, T., Rehman, S. U., Khan, A., Badshah, H., Abid, N. B., Kim, M. W., Jo, M. H., Chung, S. S., Lee, H.-G., Rutten, B. P. F., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00445-4 · Cited by 65 · see citing works
Antioxidative and Anti-inflammatory Effects of Kojic Acid in Aβ-Induced Mouse Model of Alzheimer’s Disease
Khan, A., Park, T. J., Ikram, M. A., Ahmad, S., Ahmad, R., Jo, M. G., & Kim, M. O. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02460-4 · Cited by 62 · see citing works
Adiponectin: The Potential Regulator and Therapeutic Target of Obesity and Alzheimer’s Disease
Kim, J. Y., Barua, S., Jeong, Y. J., & Lee, J. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176419 · Cited by 58 · see citing works
Mechanistic insights and emerging therapeutic stratagems for Alzheimer’s disease
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Cereboost™, an American ginseng extract, improves cognitive function via up-regulation of choline acetyltransferase expression and neuroprotection
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Lithium ameliorates lipopolysaccharide-induced neurotoxicity in the cortex and hippocampus of the adult rat brain
Khan, M. S., Ali, T., Abid, N. B., Jo, M. H., Khan, A., Kim, M. W., Yoon, G. H., Cheon, E. W., Rehman, S. U., & Kim, M. O. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.05.008 · Cited by 55 · see citing works
Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain
Ali, T., Khan, A., Alam, S. I., Ahmad, S., Ikram, M. A., Park, J. S., Lee, H. J., & Kim, M. O. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650930 · Cited by 51 · see citing works
Adiponectin Knockout Mice Display Cognitive and Synaptic Deficits
Bloemer, J., Pinky, P. D., Smith, W. D., Bhattacharya, D., Chauhan, A., Govindarajulu, M., Hong, H., Dhanasekaran, M., Judd, R. L., Amin, R., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00819 · Cited by 51 · see citing works
HMGB1/RAGE/TLR4 axis and glutamate as novel targets for PCSK9 inhibitor in high fat cholesterol diet induced cognitive impairment and amyloidosis
Abuelezz, S. A., & Hendawy, N. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119310 · Cited by 50 · see citing works
Lupeol, a Plant-Derived Triterpenoid, Protects Mice Brains against Aβ-Induced Oxidative Stress and Neurodegeneration
Ahmad, R., Khan, A., Lee, H. J., Rehman, I. U., Khan, I., Alam, S. I., & Kim, M. O. (2020) · Biomedicines · doi:10.3390/biomedicines8100380 · Cited by 50 · see citing works
Natural products in the management of neurodegenerative diseases
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Importance of adiponectin activity in the pathogenesis of Alzheimer's disease
Waragai, M., Ho, G. J., Takamatsu, Y., Sekiyama, K., Sugama, S., Takenouchi, T., Masliah, E., & Hashimoto, M. (2017) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.436 · Cited by 47 · see citing works
Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways
Chang, K.-W., Zong, H.-F., Ma, K., Zhai, W.-Y., Yang, W., Hu, X., Xu, J., Chen, X., Ji, S., & Qian, Y. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.09.005 · Cited by 43 · see citing works
Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats
Kazmi, I. A., Al-Abbasi, F. A., Afzal, M., Nadeem, M. S., & Altayb, H. N. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103560 · Cited by 43 · see citing works
Nootropic effect of neferine on aluminium chloride–induced Alzheimer's disease in experimental models
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Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals
Schön, M., Kovaničová, Z., Košutzká, Z., Nemec, M., Tomková, M., Jacková, L., Máderová, D., Slobodová, L., Valkovič, P., Ukropec, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38201-2 · Cited by 40 · see citing works
RETRACTED: Nicotinamide Ameliorates Amyloid Beta-Induced Oxidative Stress-Mediated Neuroinflammation and Neurodegeneration in Adult Mouse Brain
Rehman, I. U., Ahmad, R., Khan, I., Lee, H. J., Park, J., Ullah, R., Choi, M., Kang, H., & Kim, M. (2021) · Biomedicines · doi:10.3390/biomedicines9040408 · Cited by 33 · see citing works
Retracted
Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis
Takahashi, Y., Watanabe, R., Sato, Y., Ozawa, N., Kojima, M., Watanabe-Kominato, K., Shirai, R., Sato, K., Hirano, T., & Watanabe, T. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.010 · Cited by 40 · see citing works
Osmotin Protects H9c2 Cells from Simulated Ischemia-Reperfusion Injury through AdipoR1/PI3K/AKT Signaling Pathway
Liu, J., Sui, H., Zhao, J., & Wang, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00611 · Cited by 38 · see citing works
Adiponectin and sporadic Alzheimer’s disease: Clinical and molecular links
Letra, L., Rodrigues, T., Matafome, P. N., Santana, I. J., & Seiça, R. M. F. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.002 · Cited by 38 · see citing works
Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells
Wang, Z., Huang, X., Zhao, P., Zhao, L., & Wang, Z. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00066 · Cited by 37 · see citing works
Neuroprotective role of Ginkgo biloba against cognitive deficits associated with Bisphenol A exposure: An animal model study
Tabaa, M. M. E., Sokar, S. S., Ramadan, E. S., Salam, I. Z. A. E., & Anis, A. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.019 · Cited by 36 · see citing works
The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer’s Disease
Yoon, G., Shah, S. A., Ali, T., & Kim, M. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0847-1 · Cited by 34 · see citing works
Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta1-42 in mice
Islamie, R., Myint, S. L. L., Rojanaratha, T., Ritthidej, G. C., Wanakhachornkrai, O., Wattanathamsan, O., & Rodsiri, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04125-2 · Cited by 35 · see citing works
A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models
Lopez‐Grancha, M., Bernardelli, P., Moindrot, N., Genet, E., Vincent, C., Roudières, V., Krick, A., Sabuco, J.-F., Machnik, D., Ibghi, D., et al. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.000590 · Cited by 35 · see citing works
Kojic acid reverses LPS-induced neuroinflammation and cognitive impairment by regulating the TLR4/NF-κB signaling pathway
Ali, W., Choe, K., Park, J. S., Ahmad, R., Park, H. Y., Kang, M. H., Park, T. J., & Kim, M. O. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1443552 · Cited by 34 · see citing works
Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells via the Nrf2/HO‐1 pathway
Zhang, R.-L., Lei, B., Wu, G., Wang, Y. Y., & Huang, Q. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106210 · Cited by 34 · see citing works
Recent Studies on Protective Effects of Walnuts against Neuroinflammation
Tan, B., Wang, Y., Zhang, X., & Sun, X. (2022) · Nutrients · doi:10.3390/nu14204360 · Cited by 33 · see citing works
Crosstalk between P53 and DNA damage response in ageing
Mohammadzadeh, A., Mirza‐Aghazadeh‐Attari, M., Hallaj, S., Saei, A. A., Alivand, M. R., Valizadeh, A., Yousefi, B., & Majidinia, M. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.05.004 · Cited by 33 · see citing works
Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability?
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An 18-mer Peptide Derived from Prosaposin Ameliorates the Effects of Aβ1–42 Neurotoxicity on Hippocampal Neurogenesis and Memory Deficit in Mice
Gao, H., Li, C., Nabeka, H., Shimokawa, T., Wang, Z., Cao, Y., & Matsuda, S. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160093 · Cited by 31 · see citing works
Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in Aβ1-42-Induced Mice
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SB203580 reverses memory deficits and depression-like behavior induced by microinjection of Aβ1–42 into hippocampus of mice
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The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus
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Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations
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Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice
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Challenges in the treatment of Alzheimer’s disease: recent progress and treatment strategies of pharmaceuticals targeting notable pathological factors
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Ameliorating Activity of Ishige okamurae on the Amyloid Beta–Induced Cognitive Deficits and Neurotoxicity through Regulating ERK, p38 MAPK, and JNK Signaling in Alzheimer's Disease–Like Mice Model
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Involvement of hippocampal agmatine in β1-42 amyloid induced memory impairment, neuroinflammation and BDNF signaling disruption in mice
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Ginsenoside Rg1 reduces β‑amyloid levels by inhibiting CD5K‑induced PPARγ phosphorylation in a neuron model of Alzheimer's disease
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Combined immunotherapy with “anti-insulin resistance” therapy as a novel therapeutic strategy against neurodegenerative diseases
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Alzheimer's Disease and Its Potential Alternative Therapeutics.
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Therapeutic nanotechnologies for Alzheimer’s disease: A critical analysis of recent trends and findings
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Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
Wankhede, N. L., Kale, M. B., Bawankule, A. K., Aglawe, M. M., Taksande, B. G., Trivedi, R., Umekar, M. J., Jamadagni, A., Walse, P., Koppula, S., et al. (2023) · Nutrients · doi:10.3390/nu15173751 · Cited by 24 · see citing works
Green Tea Seed Oil Suppressed Aβ1–42-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
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Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 β and pCREB expression
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Anti-inflammatory Activity of a Polypeptide Fraction From Achyranthes bidentate in Amyloid β Oligomers Induced Model of Alzheimer’s Disease
Ge, X., Wang, Y., Yu, S., Cao, X., Chen, Y., Cheng, Q., & Ding, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716177 · Cited by 22 · see citing works
Magnoflorine-Loaded Chitosan Collagen Nanocapsules Ameliorate Cognitive Deficit in Scopolamine-Induced Alzheimer’s Disease-like Conditions in a Rat Model by Downregulating IL-1β, IL-6, TNF-α, and Oxidative Stress and Upregulating Brain-Derived Neurotrophic Factor and DCX Expressions
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Multifaceted neuroprotective approach of Trolox in Alzheimer's disease mouse model: targeting Aβ pathology, neuroinflammation, oxidative stress, and synaptic dysfunction
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Adiponectin: a potential target for obesity-associated Alzheimer’s disease
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The role of adiponectin in Alzheimer’s disease: A translational review
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Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia
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Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
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Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodegeneration in an Amyloid-β-Induced Mouse Model
Saeed, K. M., Shah, S. A., Ullah, R., Alam, S. I., Park, J. S., Saleem, S., Jo, M. H., Kim, M. W., Hahm, J. R., & Kim, M. O. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9523758 · Cited by 20 · see citing works
Retracted
AGLPM and QMDDQ peptides exert a synergistic action on memory improvement against scopolamine-induced amnesiac mice
Wu, D., Xu, X., Sun, N., Li, D., Zhu, B., & Lin, S. (2020) · Food & Function · doi:10.1039/d0fo02570d · Cited by 19 · see citing works
Dual-therapy strategy for modification of adiponectin receptor signaling in aging-associated chronic diseases
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Authors: Ali, T., Yoon, G. H., Shah, S. A., Lee, H. Y., & Kim, M. O.
Affiliations: Gyeongsang National University (KR)
Corresponding author: Kim, Myeong Ok
ORCID: Ali, Tahir
Shah, Shahid Ali
Kim, Myeong Ok
Venue: Scientific Reports
Publisher: Springer Science and Business Media LLC
Published: 2015-06-29
Volume: 5
Issue: 1
Pages: 11708-11708
ISSN: 2045-2322 (ISSN-L)
DOI: 10.1038/srep11708
PMC: PMC4484370
OpenAlex: W748543715
Cited by: 146
References: 61
Citations by year: 2026: 2 · 2025: 9 · 2024: 12 · 2023: 14 · 2022: 9 · 2021: 18 · 2020: 25 · 2019: 14 · 2018: 15 · 2017: 13 · 2016: 14 · 2015: 1
FWCI: 10.55
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Scientific Reports (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Research Foundation
National Research Foundation of Korea (2012-0009521)
Commercializations Promotion Agency for R and D Outcomes
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: osmotin, amyloid-beta 42, Alzheimer's disease, neuroprotection, memory impairment, tau hyperphosphorylation, BACE1, PI3K/Akt/GSK-3β signaling, apoptosis, neurodegeneration, hippocampus, tobacco, plant proteins, neurotoxicity
MeSH terms: Glycogen Synthase Kinase 3 beta, Animals, Behavior, Animal, Hippocampus, Male, Memory Disorders, Mice, Inbred C57BL, Neurotoxins, Phosphorylation, Plant Proteins, Synapses, Signal Transduction, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, tau Proteins, Apoptosis, Neurodegenerative Diseases, Phosphatidylinositol 3-Kinases, Glycogen Synthase Kinase 3, Proto-Oncogene Proteins c-akt

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Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

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