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Exploring the relationship between maternal prenatal stress and brain structure in premature neonates

Lautarescu, Alexandra, Hadaya, Laila, Craig, Michael C., Makropoulos, Antonis, Batalle, Dafnis, Nosarti, Chiara, Edwards, A. David, Counsell, Serena J., Victor, Suresh·2021·PLOS ONE
DOI 10.1371/journal.pone.0250413
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Abstract

Background: Exposure to maternal stress in utero is associated with a range of adverse outcomes. We previously observed an association between maternal stress and white matter microstructure in a sample of infants born prematurely. In this study, we aimed to investigate the relationship between maternal trait anxiety, stressful life events and brain volumes. Methods: 221 infants (114 males, 107 females) born prematurely (median gestational age = 30.43 weeks [range 23.57–32.86]) underwent magnetic resonance imaging around term-equivalent age (mean = 42.20 weeks, SD = 1.60). Brain volumes were extracted for the following regions of interest: frontal lobe, temporal lobe, amygdala, hippocampus, thalamus and normalized to total brain volume. Multiple linear regressions were conducted to investigate the relationship between maternal anxiety/stress and brain volumes, controlling for gestational age at birth, postmenstrual age at scan, socioeconomic status, sex, days on total parenteral nutrition. Additional exploratory Tensor Based Morphometry analyses were performed to obtain voxel-wise brain volume changes from Jacobian determinant maps. Results and conclusion: In this large prospective study, we did not find evidence of a relationship between maternal prenatal stress or trait anxiety and brain volumes. This was the case for both the main analysis using a region-of-interest approach, and for the exploratory analysis using Jacobian determinant maps. We discuss these results in the context of conflicting evidence from previous studies and highlight the need for further research on premature infants, particularly including term-born controls.

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Cited by

Metadata

Authors
Lautarescu, A., Hadaya, L., Craig, M. C., Makropoulos, A., Batalle, D., Nosarti, C., Edwards, A. D., Counsell, S. J., & Victor, S.
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2021-04-21
Volume
16
Issue
4
Pages
e0250413
ISSN
1932-6203
DOI
10.1371/journal.pone.0250413
Cited by
12
References
10
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • National Institute for Health Research (RP-PG-0707-10154)
  • Wellcome Trust (WT 203148/Z/16/Z)
  • Medical Research Council (MR/K006355/1, MR/L011530/1, MR/N013700/1)

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