Influences of prenatal and postnatal maternal depression on amygdala volume and microstructure in young children.
Open accessAbstract
Maternal depressive symptoms influence neurodevelopment in the offspring. Such effects may appear to be gender-dependent. The present study examined contributions of prenatal and postnatal maternal depressive symptoms to the volume and microstructure of the amygdala in 4.5-year-old boys and girls. Prenatal maternal depressive symptoms were measured using the Edinburgh Postnatal Depression Scale (EPDS) at 26 weeks of gestation. Postnatal maternal depression was assessed at 3 months using the EPDS and at 1, 2, 3 and 4.5 years using the Beck’s Depression Inventory-II. Structural magnetic resonance imaging and diffusion tensor imaging were performed with 4.5-year-old children to extract the volume and fractional anisotropy (FA) values of the amygdala. Our results showed that greater prenatal maternal depressive symptoms were associated with larger right amygdala volume in girls, but not in boys. Increased postnatal maternal depressive symptoms were associated with higher right amygdala FA in the overall sample and girls, but not in boys. These results support the role of variation in right amygdala structure in transmission of maternal depression to the offspring, particularly to girls. The differential effects of prenatal and postnatal maternal depressive symptoms on the volume and FA of the right amygdala suggest the importance of the timing of exposure to maternal depressive symptoms in brain development of girls. This further underscores the need for intervention targeting both prenatal and postnatal maternal depression to girls in preventing adverse child outcomes.
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Greater prenatal maternal depressive symptoms are associated with larger right amygdala volume in infants under 2 months old and girls at 4.5 years old.
“Greater prenatal maternal depressive symptoms are associated with larger right amygdala volume in infants under 2 months old and girls at 4.5 years old [39, 86, 87].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [39]
The Results (Relations between maternal depressive symptoms and the amygdala volume) report a larger right amygdala volume in 4.5-year-old girls with greater prenatal maternal depressive symptoms. The Discussion says the same cohort showed no association with amygdala volume in neonates shortly after birth, so this source does not support the claim about infants under 2 months old. (LLM, conf=0.90)
Experimental — accuracy not yet measuredThe amygdala shows selective vulnerability to prenatal maternal stress, especially in girls.
“These results underscore the selective vulnerability of the amygdala to prenatal maternal stress, especially in girls [39].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [39]
The Discussion (page unavailable) reports that greater prenatal maternal depressive symptoms predicted larger right amygdala volume in 4.5-year-old girls, but not boys. This supports a girl-specific amygdala association, but the study measured maternal depressive symptoms rather than prenatal stress generally; its findings do not establish that the amygdala is selectively vulnerable compared with other brain structures. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMaternal depression measured at 26 GW and saliva cortisol levels at 15 GW are associated with larger right amygdala volume in girls only.
“Studies suggest that maternal depression measured at 26 GW and saliva cortisol levels at 15 GW are associated with larger right amygdala volume in girls only [26, 39].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [39]
Prenatal maternal stress exposure has enduring consequences on offspring brain development and long-term neurodevelopment.
“Prenatal maternal stress exposure has been shown to have enduring consequences on brain development in the offspring”
From Association of Elevated Maternal Psychological Distress, Altered Fetal Brain, and Offspring Cognitive and Social-Emotional Outcomes at 18 Months (2022) · cites this paper as [8]
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Early environmental influences on the development of children's brain structure and function
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“Increased postnatal maternal depressive symptoms are associated with higher right amygdala fractional anisotropy, a measure of microstructural integrity, especially in females.(26) Maternal sensitivity levels correlated with connectivity between the hippocampus and areas related to emotional regulation and socio-emoti…”
BackgroundSelf-citationPrenatal stress: Effects on fetal and child brain development
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2019.11.002 · Cited by 326 · see citing works
Dadi, A. F., Miller, E. R., & Mwanri, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227323 · Cited by 245 · see citing works
“Pregnant women with depression can produce a high level of stress hormones such as cortisol that can subsequently affect fetal growth [14] and brain development [15, 16].”
BackgroundWu, Y., Lu, Y.-C., Jacobs, M., Pradhan, S., Kapse, K., Zhao, L., Niforatos-Andescavage, N., Vezina, G., du Plessis, A. J., & Limperopoulos, C. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.19940 · Cited by 218 · see citing works
Rasmussen, J. M., Graham, A. M., Entringer, S., Gilmore, J. H., Styner, M. A., Fair, D. A., Wadhwa, P. D., & Buß, C. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.020 · Cited by 211 · see citing works
Perinatal Maternal Depressive Symptoms as an Issue for Population Health
Meaney, M. J. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17091031 · Cited by 194 · see citing works
Self-citationSex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature
Sutherland, S. L., & Brunwasser, S. M. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0961-4 · Cited by 194 · see citing works
Intergenerational Effect of Maternal Exposure to Childhood Maltreatment on Newborn Brain Anatomy
Moog, N. K., Entringer, S., Rasmussen, J. M., Styner, M., Gilmore, J. H., Kathmann, N., Heim, C. M., Wadhwa, P. D., & Buss, C. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.009 · Cited by 189 · see citing works
“Previous studies that have focused on maternal stress during pregnancy (as opposed to preconceptional stress) have reported an association with hippocampus and amygdala volumes (32, 40).”
Paediatric population neuroimaging and the Generation R Study: the second wave
White, T. J. H., Muetzel, R. L., Marroun, H. E., Blanken, L. M. E., Jansen, P. R., Bolhuis, K., Kocevska, D., Mous, S. E., Mulder, R. H., Jaddoe, V. W. V., et al. (2017) · European Journal of Epidemiology · doi:10.1007/s10654-017-0319-y · Cited by 172 · see citing works
“[134, 135] GUSTO Longitudinal Population-based 120 neonates 40.”
Prenatal stress and the developing brain: Risks for neurodevelopmental disorders
den Bergh, B. R. H. V., Dahnke, R., & Mennes, M. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000342 · Cited by 160 · see citing works
“While some studies found effects only in females (Buss et al., 2012; Wen et al., 2017), because few studies explicitly examined sex differences, no firm conclusions can be reached at this point.”
BackgroundResultInfluentialPerinatal depression and infant mental health
Goodman, J. H. (2019) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2019.01.010 · Cited by 154 · see citing works
The influence of unpredictable, fragmented parental signals on the developing brain
Glynn, L. M., & Baram, T. Z. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.01.002 · Cited by 146 · see citing works
“The documented effects on mental health are associated with altered maturation of neural circuits, which persists until adulthood (Soe et al., 2018; Wen et al., 2017; Lebel et al., 2016; Posner et al., 2016; Sandman et al., 2015).”
Dean, D. C., Planalp, E. M., Wooten, W., Kecskemeti, S. R., Adluru, N., Schmidt, C. K., Frye, C., Birn, R. M., Burghy, C. A., Schmidt, N. L., et al. (2018) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2018.2132 · Cited by 138 · see citing works
Wu, Y., De Asis-Cruz, J., & Limperopoulos, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02449-0 · Cited by 124 · see citing works
Wu, Y., Espinosa, K. M., Barnett, S. D., Kapse, A., Quistorff, J. L., Lopez, C., Andescavage, N., Pradhan, S., Lu, Y.-C., Kapse, K., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.9244 · Cited by 113 · see citing works
“NA 2 8 (8) NA 8 (23) 3 9 (9) NA 9 (26) 4 6 (6) NA 6 (17) Abbreviation: NA, not applicable.”
InfluentialQiu, A., Shen, M., Buß, C., Chong, Y. S., Kwek, K. Y. C., Saw, S., Gluckman, P. D., Wadhwa, P. D., Entringer, S., Styner, M. A., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx065 · Cited by 116 · see citing works
“Antenatal maternal depression, independent of postnatal maternal mood, influences fetal neurodevelopment, in particular the amygdala, where alterations associate with affective disorders (Rifkin-Graboi et al. 2013; Qiu et al. 2015a; Wen et al. 2017).”
BackgroundSelf-citationMaternal psychological distress during pregnancy and childhood health outcomes: a narrative review
Vehmeijer, F. O. L., Guxens, M., Duijts, L., & El Marroun, H. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000557 · Cited by 107 · see citing works
Jones, S. L., Dufoix, R., Laplante, D. P., Elgbeili, G., Patel, R., Chakravarty, M. M., King, S., & Pruessner, J. C. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00144 · Cited by 92 · see citing works
“, 2013), with AGV in childhood as well as with structural changes in the amygdala in the neonatal period and childhood (Rifkin-Graboi et al., 2013; Favaro et al., 2015; Posner et al., 2016; Scheinost et al., 2016; Wen et al., 2017).”
BackgroundGuadagno, A., Belliveau, C., Mechawar, N., & Walker, C. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.669120 · Cited by 92 · see citing works
“…was observed in males, but not females, from infancy until adulthood (Uematsu et al., 2012) and it is believed that the right and left amygdala develop at different rates and may be involved in different emotional regulation processes (Wager et al., 2003; Uematsu et al., 2012; Wen et al., 2017).”
BackgroundBrain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies
Mohammadi, S., Seyedmirzaei, H., Salehi, M. A., Jahanshahi, A., Zakavi, S. S., Firouzabadi, F. D., & Yousem, D. M. (2023) · Brain Imaging and Behavior · doi:10.1007/s11682-023-00772-8 · Cited by 87 · see citing works
“…Savitz et al., 2011; Schmaal et al., 2017a; Soe et al., 2018; Takahashi et al., 2016; Tol et al., 2010; Wang et al., 1991, 2019; Wei et al., 2021; Wen et al., 2017; Woo et al., 2009; Wu et al., 1993; Zhang et al., 1991), 26 studies due to not assessing major depression (Averill et al., 2017;…”
Perinatal maternal depressive symptoms alter amygdala functional connectivity in girls
Soe, N. N., Wen, D. J., Poh, J. S., Chong, Y., Broekman, B. F., Chen, H., Shek, L. P., Tan, K. H., Gluckman, P. D., Fortier, M. V., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.23873 · Cited by 86 · see citing works
“Using the same sample, we previously also showed that pre- and post-natal maternal depressive respectively impact the amygdala volume and microstructure in girls (Wen et al., 2017).”
BackgroundInfluentialSelf-citationAcosta, H., Tuulari, J. J., Scheinin, N. M., Hashempour, N., Rajasilta, O., Lavonius, T. I., Pelto, J., Saunavaara, V., Parkkola, R., Lähdesmäki, T., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00175 · Cited by 80 · see citing works
Zou, R., Tiemeier, H. W., van der Ende, J., Verhulst, F. C., Muetzel, R. L., White, T. J. H., Hillegers, M. H. J., & Marroun, H. E. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18080970 · Cited by 77 · see citing works
Lautarescu, A., Pecheva, D., Nosarti, C., Sigurðardottir, J. N., Zhang, H. G., Victor, S., Craig, M., Edwards, A. D., & Counsell, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.08.010 · Cited by 72 · see citing works
Cattane, N., Räikkönen, K., Anniverno, R., Mencacci, C., Riva, M. A., Pariante, C. M., & Cattaneo, A. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0813-6 · Cited by 77 · see citing works
“tural development of the amygdala, with evidence for gender-specific effects [33].”
BackgroundA review on neuroimaging studies of genetic and environmental influences on early brain development
Gao, W., Grewen, K., Knickmeyer, R. C., Qiu, A., Salzwedel, A., Lin, W., & Gilmore, J. H. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.032 · Cited by 69 · see citing works
Self-citationThe impact of maternal depression, anxiety, and stress on early neurodevelopment in boys and girls
Zhang, T., Luo, Z., Ji, Y., Chen, Y., Ma, R., Fan, P., Tang, N., Li, J., Tian, Y., Zhang, J., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.10.030 · Cited by 71 · see citing works
Stoye, D. Q., Blesa, M., Sullivan, G., Galdi, P., Lamb, G. J., Black, G. S., Quigley, A. J., Thrippleton, M. J., Bastin, M. E., Reynolds, R. M., et al. (2020) · eLife · doi:10.7554/elife.60729 · Cited by 66 · see citing works
Moog, N. K., Nolvi, S., Kleih, T. S., Styner, M. A., Gilmore, J. H., Rasmussen, J. M., Heim, C. C., Entringer, S., Wadhwa, P. D., & Buß, C. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100368 · Cited by 63 · see citing works
Monteiro, F., Pereira, M., Canavarro, M. C., & Fonseca, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17134679 · Cited by 58 · see citing works
“Mental illness during the postpartum period has increasingly been considered a high-priority public health problem due to the long-term negative implications for maternal health, infant health and development [11,12] and economic costs [13,14].”
BackgroundPrenatal and postnatal maternal anxiety and amygdala structure and function in young children
Donnici, C., Long, X., Dewey, D., Letourneau, N., Landman, B., Huo, Y., & Lebel, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-83249-2 · Cited by 54 · see citing works
Research Review: Developmental origins of depression – a systematic review and meta‐analysis
Su, Y., D’Arcy, C., & Meng, X. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13358 · Cited by 55 · see citing works
“A great deal of physiological changes of depressed mothers during pregnancy posit an adverse intrauterine environment which can alter fetal developmental programming (Wen et al., 2017).”
BackgroundRobinson, R., Lahti‐Pulkkinen, M., Heinonen, K., Reynolds, R. M., & Räikkönen, K. (2018) · Pediatric Research · doi:10.1038/s41390-018-0173-y · Cited by 55 · see citing works
Franke, K., den Bergh, B. V. D. V., de Rooij, S., Kroegel, N., Nathanielsz, P., Rakers, F., Roseboom, T., Witte, O. W., & Schwab, M. (2020) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.031 · Cited by 32 · see citing works
“year-old female but not male offspring, even when controlling for postnatal maternal depressive symptoms (Wen et al., 2017).”
BackgroundInfluentialManning, K. Y., Long, X., Watts, D., Tomfohr-Madsen, L., Giesbrecht, G. F., & Lebel, C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.05.011 · Cited by 51 · see citing works
Duan, C., Hare, M. M., Staring, M., & Deligiannidis, K. M. (2019) · International Review of Psychiatry · doi:10.1080/09540261.2018.1527759 · Cited by 50 · see citing works
“MRI, with a focus on the amygdala (Wen et al., 2017).”
BackgroundInfluentialDoes Prenatal Maternal Distress Contribute to Sex Differences in Child Psychopathology?
Hicks, L. M., Swales, D. A., Garcia, S. E., Driver, C., & Davis, E. P. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-0992-5 · Cited by 51 · see citing works
Hay, R. E., Reynolds, J. E., Grohs, M. N., Paniukov, D., Giesbrecht, G. F., Letourneau, N. L., Dewey, D., & Lebel, C. A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0481-20.2020 · Cited by 50 · see citing works
“…prenatal depression is associated with altered amygdala functional connectivity in 6-month-old infants and 4.5-year-old children (Qiu et al., 2015; Wen et al., 2017), altered right amygdala microstructure at birth (Rifkin-Graboi et al., 2013), lower frontal and parietal brain activation (Dawson…”
BackgroundInfluentialLu, Y.-C., Andescavage, N., Wu, Y., Kapse, K., Andersen, N. R., Quistorff, J., Saeed, H., Lopez, C., Henderson, D., Barnett, S. D., et al. (2022) · Communications Medicine · doi:10.1038/s43856-022-00111-w · Cited by 46 · see citing works
Lehtola, S. J., Tuulari, J. J., Scheinin, N. M., Karlsson, L., Parkkola, R., Merisaari, H., Lewis, J. D., Fonov, V. S., Louis Collins, D., Evans, A., et al. (2020) · NeuroImage: Clinical · doi:10.1016/j.nicl.2020.102380 · Cited by 51 · see citing works
“5year-olds (Wen et al., 2017) and higher maternal prenatal cortisol”
InfluentialPrenatal stress impacts foetal neurodevelopment: Temporal windows of gestational vulnerability
Collins, J. M., Keane, J. M., Deady, C., Khashan, A. S., McCarthy, F. P., O’Keeffe, G. W., Clarke, G. A., Cryan, J. F., Caputi, V., & O’Mahony, S. M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105793 · Cited by 50 · see citing works
Brunst, K. J., Ryan, P., Altaye, M., Yolton, K. A., Maloney, T., Beckwith, T. J., LeMasters, G. K., & Cecil, K. M. (2019) · Environmental Research · doi:10.1016/j.envres.2019.05.009 · Cited by 45 · see citing works
Prenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory
Koc, D., Tiemeier, H., Stricker, B. H., Muetzel, R. L., Hillegers, M., & El Marroun, H. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.3161 · Cited by 44 · see citing works
El Marroun, H., Zou, R., Muetzel, R. L., Jaddoe, V. W., Verhulst, F. C., White, T., & Tiemeier, H. (2018) · Depression and Anxiety · doi:10.1002/da.22722 · Cited by 45 · see citing works
Change of pace: How developmental tempo varies to accommodate failed provision of early needs
Roubinov, D. S., Meaney, M. J., & Boyce, W. T. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.031 · Cited by 40 · see citing works
Self-citationFitzgerald, E., Parent, C. I., Kee, M. Z. L., & Meaney, M. J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.635304 · Cited by 39 · see citing works
Self-citationOmega-3 and its domain-specific effects on cognitive test performance in youths: A meta-analysis
Emery, S., Häberling, I. S., Berger, G. E., Walitza, S., Schmeck, K., Albert, T., Baumgartner, N., Strumberger, M. A., Albermann, M., & Drechsler, R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.016 · Cited by 36 · see citing works
Exposure to prenatal maternal distress and infant white matter neurodevelopment
Demers, C. H., Bagonis, M. M., Al‐Ali, K., Garcia, S. E., Styner, M. A., Gilmore, J. H., Hoffman, M. C., Hankin, B. L., & Davis, E. P. (2021) · Development and Psychopathology · doi:10.1017/s0954579421000742 · Cited by 36 · see citing works
“In an effort to isolate the unique effects of the distress during the prenatal period, several studies have investigated whether associations remain even when controlling for postnatal distress (El Marroun et al., 2018; Lebel et al., 2016; Wen et al., 2017).”
BackgroundMaternal care in infancy and the course of limbic development
Lee, A., Poh, J. S., Wen, D. J. R., Tan, H. M., Chong, Y. S., Tan, K. H., Gluckman, P. D., Fortier, M. V., Rifkin‐Graboi, A., & Qiu, A. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100714 · Cited by 34 · see citing works
“Even though prenatal maternal depressive symptoms also impact brain development of offspring (Gao et al., 2019; Lee et al., 2019; Lugo-Candelas et al., 2018; Ong et al., 2019; Qiu et al., 2015b, 2017; Rifkin-Graboi et al., 2013; Wang et al., 2018, 2019a; Wen et al., 2017), this study did not include prenatal maternal…”
Self-citationHuang, X., Wang, Y., Wang, Y., Guo, X., Zhang, L., Wang, W., & Shen, J. (2023) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-023-05672-9 · Cited by 34 · see citing works
Mareckova, K., Miles, A., Andryskova, L., Brazdil, M., & Nikolova, Y. S. (2020) · Human Brain Mapping · doi:10.1002/hbm.25163 · Cited by 32 · see citing works
Acosta, H., Kantojärvi, K., Hashempour, N., Pelto, J., Scheinin, N. M., Lehtola, S. J., Lewis, J. D., Fonov, V. S., Collins, D. L., Evans, A., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa158 · Cited by 34 · see citing works
Maternal sensitivity predicts anterior hippocampal functional networks in early childhood
Wang, Q., Zhang, H., Chong-yaw Wee, A., Lee, A., Poh, J. S., Chong, Y. S., Tan, K. H., Gluckman, P. D., Yap, F. K. P., Fortier, M. V., et al. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01882-0 · Cited by 31 · see citing works
Self-citationPrenatal and postnatal depressive symptoms, infant white matter, and toddler behavioral problems
Borchers, L. R., Dennis, E. L., King, L. S., Humphreys, K. L., & Gotlib, I. H. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.075 · Cited by 30 · see citing works
“Further, Wen et al. (2017) reported that whereas prenatal depressive symptoms were associated with larger right amygdala volume, postnatal depressive symptoms were associated with higher fractional anisotropy (FA) of the right amygdala.”
BackgroundResultInfluentialGarcia-Leal, C., de Rezende, M. G., Zuelli, F. M. D. G. C., de Castro, M., & Del‐Ben, C. M. (2017) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2017.1347500 · Cited by 30 · see citing works
Savory, K. A., Garay, S. M., Sumption, L. A., Kelleher, J. S., Daughters, K., Janssen, A. B., van Goozen, S. H. M., & John, R. M. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.057 · Cited by 28 · see citing works
“5 year old daughters but not sons (Wen et al., 2017).”
BackgroundMonteiro, F., Fonseca, A., Pereira, M., & Canavarro, M. C. (2020) · Journal of Clinical Psychology · doi:10.1002/jclp.23081 · Cited by 30 · see citing works
Lund, R., Kyläniemi, M. K., Pettersson, N., Kaukonen, R., Konki, M., Scheinin, N. M., Karlsson, L., Karlsson, H., & Ekholm, E. M. K. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100374 · Cited by 28 · see citing works
The influence of maternal anxiety and cortisol during pregnancy on childhood anxiety symptoms
McGuinn, L. A., Tamayo‐Ortiz, M., Rosa, M. J., Harari, H. C., Osorio-Valencia, E., Schnaas, L., Hernández-Chávez, C., Wright, R. J., Klein, D. N., Téllez‐Rojo, M. M., et al. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105704 · Cited by 29 · see citing works
Wang, Q., Poh, J. S., Wen, D. J. R., Broekman, B. F. P., Chong, Y. S., Yap, F. K. P., Shek, L. P., Gluckman, P. D., Fortier, M. V., & Qiu, A. (2018) · Depression and Anxiety · doi:10.1002/da.22874 · Cited by 28 · see citing works
Self-citationInflammatory modulation of the associations between prenatal maternal depression and neonatal brain
Wu, Y., Zhang, H., Wang, C., Broekman, B. F. P., Chong, Y. S., Shek, L. P., Gluckman, P. D., Meaney, M. J., Fortier, M. V., & Qiu, A. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0774-0 · Cited by 27 · see citing works
Self-citationCattarinussi, G., Aarabi, M. H., Moghaddam, H. S., Homayoun, M., Ashrafi, M., Hamid Soltanian-zadeh, A., & Sambataro, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.046 · Cited by 27 · see citing works
Fluoride exposure during early adolescence and its association with internalizing symptoms
Adkins, E. A., Yolton, K. A., Strawn, J. R., Lippert, F., Ryan, P., & Brunst, K. J. (2021) · Environmental Research · doi:10.1016/j.envres.2021.112296 · Cited by 27 · see citing works
A Golden Thread approach to transforming Maternal and Child Health in Singapore
Yap, F. K. P., Loy, S. L., Ku, C. W., Chua, M. C., Godfrey, K. M., & Chan, J. K. Y. (2022) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-04893-8 · Cited by 28 · see citing works
“Emerging evidence shows that the children of mothers with depressive symptoms during pregnancy are at risk of altered structural brain development, as well as poor school-readiness and performance in early childhood [19, 20].”
BackgroundPrenatal Programming of Neurodevelopment: Structural and Functional Changes
Demers, C. H., Aran, Ö., Glynn, L. M., & Davis, E. P. (2021) · Springer eBooks · doi:10.1007/978-3-030-60159-1_9 · Cited by 25 · see citing works
Lyons‐Ruth, K., Li, F. H., Khoury, J. E., Ahtam, B., Sisitsky, M. D., Ou, Y., Enlow, M. B., & Grant, P. E. (2023) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-023-01041-4 · Cited by 30 · see citing works
Khoury, J. E., Ahtam, B., Sisitsky, M. D., Ou, Y., Gagoski, B. A., Enlow, M. B., Teicher, M. H., Grant, P. E., & Lyons‐Ruth, K. (2021) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.09.005 · Cited by 26 · see citing works
“Maternal depressive symptoms have previously been associated with infant brain volume (16,27,28), and thus, maternal depressive symptoms were considered as a covariate.”
BackgroundKhan, S., Siddique, R., Xiao, H., Lin, Y., Liu, Y., Wang, X., Hua, L., & Nabi, G. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.66906 · Cited by 25 · see citing works
“Similarly, a positive correlation was reported between prenatal stress, and greater right amygdala volume, and altered neural activity and connectivity in girls but not in boys in childhood (30,31).”
BackgroundPrenatal stress and its association with amygdala-related structural covariance patterns in youth
Marečková, K., Miles, A. E., Liao, Z., Andrýsková, L., Brázdil, M., Paus, T., & Nikolova, Y. S. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.102976 · Cited by 26 · see citing works
“Associations between maternal stress during pregnancy and offspring brain structure and function have been reported in fetuses (5), newborns (6-9), children (10-13), adolescents and young adults (3, 13-15).”
InfluentialLee, A., Poh, J. S., Wen, D. J. R., Guillaume, B., Chong, Y. S., Shek, L. P., Fortier, M. V., & Qiu, A. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.05.006 · Cited by 25 · see citing works
Self-citationQiu, A., Zhang, H., Wang, C., Chong, Y.-S., Shek, L. P., Gluckman, P. D., Meaney, M. J., Fortier, M. V., & Wu, Y. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01292-z · Cited by 23 · see citing works
Self-citationKhoury, J. E., Enlow, M. B., Patwa, M. C., & Lyons‐Ruth, K. (2020) · Developmental Psychobiology · doi:10.1002/dev.21950 · Cited by 23 · see citing works
“, Allen, Oshri, Rogosch, Toth, & Cicchetti, 2019; Bureau, Easterbrooks, & Lyons-Ruth, 2009; Silk, Shaw, Forbes, Lane, & Kovacs, 2006), and enlarged amygdala volume and altered amygdala functional connectivity in offspring (e.g., Buss et al., 2011; Qiu et al., 2015; Wen et al., 2017).”
Komanchuk, J., Letourneau, N. L., Duffett‐Leger, L., & Cameron, J. L. (2023) · Issues in Mental Health Nursing · doi:10.1080/01612840.2023.2192794 · Cited by 24 · see citing works
“Maternal depressive symptoms have also been associated with larger right amygdala volume in preschool-aged girls (Wen et al., 2017), larger right and left amygdala volumes in 10-yearolds (Lupien et al., 2011), and decreased right hemisphere cortical thickness in preschool children (Lebel et al.,…”
BackgroundQiu, A., & Liu, C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01559-7 · Cited by 19 · see citing works
Self-citationTuresky, T. K., Shama, T., Kakon, S. H., Haque, R., Islam, N., Someshwar, A., Gagoski, B. A., Petri, W. A., Nelson, C. A., & Gaab, N. (2021) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2021.101029 · Cited by 19 · see citing works
“, familial conflict) (Sheridan and McLaughlin, 2014), both of which have been associated with alterations in early brain structure (Rao et al., 2010; Tottenham et al., 2010; Sheridan et al., 2012; McLaughlin et al., 2014b; Lebel et al., 2016; Wen et al., 2017; Spann et al., 2020; VanTieghem et al., 2021).”
Suor, J. H., Granros, M., Calentino, A. E., Phan, K. L., & Burkhouse, K. L. (2021) · Development and Psychopathology · doi:10.1017/s0954579421000857 · Cited by 21 · see citing works
“…depression might exert differential impacts on processing of affective stimuli and neural structures implicated in depression vulnerability (e.g., Wen et al., 2017), and that more chronic maternal depressive symptoms are associated with increased probability for childhood psychopathology among…”
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Groenewold, N. A., Wedderburn, C. J., Pellowski, J. A., Fouché, J.-P., Michalak, L., Roos, A., Woods, R. P., Narr, K. L., Zar, H. J., Donald, K. A., et al. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.103206 · Cited by 22 · see citing works
Hashempour, N., Tuulari, J. J., Merisaari, H., Acosta, H., Lewis, J. D., Pelto, J., Scheinin, N. M., Fonov, V. S., Collins, D. L., Lehtola, S. J., et al. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15989 · Cited by 20 · see citing works
“PMDS exposures have been observed to associate with the amygdala in a sex-specific manner (Acosta, Kantojärvi, et al., 2020; Acosta, Tuulari, et al., 2020; Lehtola et al., 2020; Wen et al., 2017).”
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Harnett, N. G., Merrill, L. C., & Fani, N. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01901-7 · Cited by 19 · see citing works
Tuulari, J. J., Kataja, E., Leppänen, J. M., Lewis, J. D., Nolvi, S., Häikiö, T., Lehtola, S. J., Hashempour, N., Saunavaara, J. P., Scheinin, N. M., et al. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100839 · Cited by 19 · see citing works
“Early amygdala volume may also be linked to environmental factors, including maternal pre- and postnatal psychological distress and fear bias (Rifkin-Graboi et al., 2013; Wen et al., 2017).”
BackgroundGui, Y., Deng, Y., Sun, X., Li, W., Rong, T., Wang, X., Jiang, Y., Zhu, Q., Liu, J., Wang, G., et al. (2022) · SLEEP · doi:10.1093/sleep/zsac037 · Cited by 18 · see citing works
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“13 relationships between maternal postpartum psychological distress and offspring WM microstructure have been successfully demonstrated only in previous studies evaluating the immediate two to three months after birth(6,7,38).”
InfluentialWong, G., Weir, J. M., Mishra, P., Huynh, K., Nijagal, B., Gupta, V., Broekman, B. F. P., Chong, M. F., Chan, S., Tan, K. H., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01208-x · Cited by 18 · see citing works
Self-citationSánchez-Rubio, M., Abarzúa-Catalán, L., del Valle, A., Méndez-Ruette, M., Salazar, N., Sigala, J., Sandoval, S., Godoy, M. I., Luarte, A., Monteiro, L. J., et al. (2024) · Biological Research · doi:10.1186/s40659-024-00548-4 · Cited by 17 · see citing works
“Structural and functional brain changes, such as reduced gray matter volume [29], enlarged amygdala [30, 31], and decreased hippocampal volume [31], may underlie PS-related neurodevelopmental outcomes.”
BackgroundZhang, H., Wong, T. Y., Broekman, B. F. P., Chong, Y. S., Shek, L. P., Gluckman, P. D., Tan, K. H., Meaney, M. J., Fortier, M. V., & Qiu, A. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab081 · Cited by 17 · see citing works
“Converging evidence from research in development and psychopathology suggests that maternal adverse childhood experience, such as sexual abuse, emotional and physical abuse and neglect, has a long-term impact on emotional, cognitive, and behavioral outcomes, and increases a risk for psychopathology in the offspring (W…”
BackgroundMethodInfluentialSelf-citationAcosta, H., Kantojärvi, K., Tuulari, J. J., Lewis, J. D., Hashempour, N., Scheinin, N. M., Lehtola, S. J., Fonov, V., Collins, D. L., Evans, A. C., et al. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24722 · Cited by 16 · see citing works
“…psychiatric disease susceptibility can originate in early life stages (Kim, Bale, & Epperson, 2015; O'Donnell & Meaney, 2017; Rice et al., 2010), and might to some extent be mediated by altered offspring brain development (Acosta et al., 2019; Sandman, Buss, Head, & Davis, 2015; Wen et al., 2017).”
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Guérin‐Marion, C., Sezlik, S., & Bureau, J. (2020) · European Journal of Psychotraumatology · doi:10.1080/20008198.2020.1802908 · Cited by 16 · see citing works
“, 2015), and prospectively across childhood (Bernier et al., 2019; Lee et al., 2019; Lupien et al., 2011; Wen et al., 2017) and adulthood (Khoury, Pechtel, Andersen, Teicher, & Lyons-Ruth, 2019; Lyons-Ruth, Pechtel, Yoon,”
BackgroundJirsaraie, R. J., Palma, A. M., Small, S. L., Sandman, C. A., Davis, E. P., Baram, T. Z., Stern, H. S., Glynn, L. M., & Yassa, M. A. (2023) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2023.08.002 · Cited by 16 · see citing works
Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter
Marečková, K., Mareček, R., Andrýsková, L., Brázdil, M., & Nikolova, Y. S. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.07.009 · Cited by 15 · see citing works
On the role of the amygdala for experiencing fatigue in patients with multiple sclerosis
Hanken, K., Francis, Y., Kastrup, A., Eling, P., Klein, J., & Hildebrandt, H. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.12.014 · Cited by 16 · see citing works
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Self-citationNeural markers of familial risk for depression – A systematic review
Nazarova, A., Schmidt, M. H., Cookey, J., & Uher, R. (2022) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2022.101161 · Cited by 15 · see citing works
“Sex differences in structural brain alterations have been reported in younger samples of FHR youth (Acosta et al., 2020; Soe et al., 2018; Wen et al., 2017).”
InfluentialNa, X., Glasier, C. M., Andres, A., Bellando, J. B., Chen, H., Gao, W., Livingston, L. W., Badger, T. M., & Ou, X. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad176 · Cited by 15 · see citing works
Self-citationWang, Q., Zhang, H., Poh, J. S., Pecheva, D., Broekman, B. F. P., Chong, Y. S., Shek, L. P., Gluckman, P. D., Fortier, M. V., Meaney, M. J., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz135 · Cited by 14 · see citing works
Self-citationNatural Disasters and Pregnancy: Population-Level Stressors and Interventions
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In search of sex-related mediators of affective illness
Sikes-Keilp, C., & Rubinow, D. R. (2021) · Biology of Sex Differences · doi:10.1186/s13293-021-00400-4 · Cited by 13 · see citing works
Kott, J., & Brummelte, S. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.01.004 · Cited by 13 · see citing works
- Authors
- Wen, D. J., Poh, J. S., Ni, S. N., Chong, Y.-S., Chen, H., Kwek, K., Shek, L. P., Gluckman, P. D., Fortier, M. V., Meaney, M. J., & Qiu, A.
- Affiliations
- National University of Singapore (SG)
- Singapore Institute for Clinical Sciences (SG)
- KK Women's and Children's Hospital (SG)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Qiu, A
- Venue
- Translational Psychiatry
- Published
- 2017-04-25
- Volume
- 7
- Issue
- 4
- Pages
- e1103-e1103
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC5416711
- OpenAlex
- W2609899196
- Cited by
- 186
- References
- 85
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 17 · 2023: 23 · 2022: 22 · 2021: 28 · 2020: 28 · 2019: 25 · 2018: 11 · 2017: 6 · 2016: 1
- FWCI
- 17.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- Hope for Depression Research Foundation
- Harvard University
- JPB Foundation
- National University Health System
- Medical Research Council (NMRC/TCR/004-NUS/2008, NMRC/TCR/012-NUHS/2014)
- National Medical Research Council (NMRC/TCR/004- NUS /2008, NMRC /CBRG/0039/2013, NMRC/TCR/004, NMRC/TCR/012-NUHS/2014)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- maternal depression, antenatal depression, postpartum depression, amygdala volume, fractional anisotropy, sex differences, child neurodevelopment, young children
- MeSH terms
- Amygdala, Birth Weight, Brain, Child, Preschool, Depressive Disorder, Female, Gestational Age, Humans, Magnetic Resonance Imaging, Male, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Anisotropy, Depression, Postpartum, Diffusion Tensor Imaging, Neuroimaging, Neurodevelopmental Disorders
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