Cited by 578Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and Metabolism

Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans

Wang, Yu, Lam, Karen S L, Kraegen, Edward W, Sweeney, Gary, Zhang, Jialiang, Tso, Annette WK, Chow, Wing-Sun, Wat, Nelson MS +3 more·2007·Clinical Chemistry

Abstract

Background: Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies. Methods: We used real-time PCR and in-house immunoassays to quantify the mRNA and serum concentrations of lipocalin-2 in C57BL/KsJ db/db obese mice and their age- and sex-matched lean littermates. We analyzed the association between serum lipocalin-2 concentrations and various metabolic and inflammatory variables in 229 persons (121 men and 108 women) recruited from a previous cross-sectional study, and we evaluated the effect of the insulin-sensitizing drug rosiglitazone on serum lipocalin-2 concentrations in 32 diabetic patients (21 men and 11 women). Results: Compared with the lean littermates, lipocalin-2 mRNA expression in adipose tissue and liver and its circulating concentrations were significantly increased in db/db diabetic/obese mice (P <0.001). These changes were normalized after rosiglitazone treatment. In humans, circulating lipocalin-2 concentrations were positively correlated (P <0.005) with adiposity, hypertriglyceridemia, hyperglycemia, and the insulin resistance index, but negatively correlated (P = 0.002) with HDL cholesterol. There was also a strong positive association between lipocalin-2 concentrations and high sensitivity C-reactive protein (hs-CRP), independent of age, sex, and adiposity (P = 0.007). Furthermore, rosiglitazone-mediated decreases in lipocalin-2 concentrations correlated significantly with increases in insulin sensitivity (r = 0.527; P = 0.002) and decreases in hs-CRP concentrations (r = 0.509; P = 0.003). Conclusions: Lipocalin-2 is an inflammatory marker closely related to obesity and its metabolic complications. Measurement of serum lipocalin-2 might be useful for evaluating the outcomes of various clinical interventions for obesity-related metabolic and cardiovascular diseases.

Integrity signals

Registry

Crossref · 10.1373/clinchem.2006.075614

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wang, Y., Lam, K. S. L., Kraegen, E. W., Sweeney, G., Zhang, J., Tso, A. W., Chow, W.-S., Wat, N. M., Xu, J. Y., Hoo, R. L., & Xu, A.
Affiliations
  • Genome Research Center and Department of Biochemistry,
  • University of Hong Kong (HK)
  • Garvan Institute of Medical Research (AU)
  • York University (CA)
  • Research Center of Heart, Brain, Hormone and Healthy Aging, and
Corresponding author
Xu, Aimin
Venue
Clinical Chemistry
Published
2007-01-01
Volume
53
Issue
1
Pages
34-41
ISSN
  • 0009-9147 (ISSN-L)
  • 1530-8561
OpenAlex
W2123416046
Cited by
578
References
42
Citations by year
2026: 18 · 2025: 29 · 2024: 31 · 2023: 28 · 2022: 45 · 2021: 36 · 2020: 28 · 2019: 39 · 2018: 31 · 2017: 33 · 2016: 20 · 2015: 31 · 2014: 43 · 2013: 35 · 2012: 34
FWCI
12.45
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
neutrophil gelatinase-associated lipocalin, obesity, insulin resistance, hyperglycemia, inflammation, C-reactive protein, adipose tissue, liver, rosiglitazone, type 2 diabetes, hypertriglyceridemia, HDL cholesterol, db/db mice, biomarkers
MeSH terms
Lipocalin-2, Rosiglitazone, Acute-Phase Proteins, Adult, Age Factors, Aged, Animals, C-Reactive Protein, Diabetes Mellitus, Type 2, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hyperglycemia, Inflammation, Insulin Resistance, Male, Mice, Inbred C57BL, Mice, Obese, Middle Aged, Obesity, Proto-Oncogene Proteins, Sex Factors, Biomarkers, Oncogene Proteins, Body Mass Index, Polymerase Chain Reaction, Thiazolidinediones, PPAR gamma, Mice, Lipocalins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review