Cited by 680Genetic Associations and EpidemiologyGenetics and Physical PerformanceCognitive Abilities and Testing

Heritability of Adult Body Height: A Comparative Study of Twin Cohorts in Eight Countries

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Silventoinen, Karri, Sammalisto, Sampo, Perola, Markus, Boomsma, Dorret I., Cornes, Belinda K., Davis, Chayna, Dunkel, Leo, de Lange, Marlies +12 more·2003·Twin Research

Abstract

A major component of variation in body height is due to genetic differences, but environmental factors have a substantial contributory effect. In this study we aimed to analyse whether the genetic architecture of body height varies between affluent western societies. We analysed twin data from eight countries comprising 30,111 complete twin pairs by using the univariate genetic model of the Mx statistical package. Body height and zygosity were self-reported in seven populations and measured directly in one population. We found that there was substantial variation in mean body height between countries; body height was least in Italy (177 cm in men and 163 cm in women) and greatest in the Netherlands (184 cm and 171 cm, respectively). In men there was no corresponding variation in heritability of body height, heritability estimates ranging from 0.87 to 0.93 in populations under an additive genes/unique environment (AE) model. Among women the heritability estimates were generally lower than among men with greater variation between countries, ranging from 0.68 to 0.84 when an additive genes/shared environment/unique environment (ACE) model was used. In four populations where an AE model fit equally well or better, heritability ranged from 0.89 to 0.93. This difference between the sexes was mainly due to the effect of the shared environmental component of variance, which appears to be more important among women than among men in our study populations. Our results indicate that, in general, there are only minor differences in the genetic architecture of height between affluent Caucasian populations, especially among men.

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  • Body height is approximately 70-90% inherited.

    “Body height is approximately 70-90% inherited (121)”
  • Among nonhormonal factors, genetics explains a large proportion (~50% to 60% from pooled twin studies) of the variability in muscle mass and strength.

    “Among the nonhormonal factors, genetics explains a large proportion [∼50% to 60% from pooled twin studies (156)] of the variability in muscle mass and strength (157, 158) and may be explained in turn by the equally high genetic contributions to circulating testosterone (37, 38).”

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Research works printed but not linked: 6

  1. Barker, D. J. P. (1998). Mothers, babies and health in later life (2nd ed.). Edinburgh: Churchill Livingstone.
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Authors
Silventoinen, K., Sammalisto, S., Perola, M., Boomsma, D. I., Cornes, B. K., Davis, C., Dunkel, L., de Lange, M., Harris, J. R., Hjelmborg, J. V. B., Luciano, M., Martin, N. G., Mortensen, J., Nisticò, L., Pedersen, N. L., Skytthe, A., Spector, T. D., Stazi, M. A., Willemsen, G., & Kaprio, J.
Affiliations
  • University of Helsinki (FI)
  • Vrije Universiteit Amsterdam (NL)
  • QIMR Berghofer Medical Research Institute (AU)
  • Karolinska Institutet (SE)
  • Norwegian Institute of Public Health (NO)
  • University of Southern Denmark (DK)
  • Istituto Superiore di Sanità (IT)
  • St Thomas' Hospital (GB)
Corresponding author
Kaprio, Jaakko
Venue
Twin Research
Published
2003-10-01
Volume
6
Issue
5
Pages
399-408
ISSN
  • 1369-0523 (ISSN-L)
  • 0000-0000
OpenAlex
W2106294125
Cited by
680
References
62
Citations by year
2026: 11 · 2025: 25 · 2024: 25 · 2023: 31 · 2022: 24 · 2021: 40 · 2020: 23 · 2019: 46 · 2018: 51 · 2017: 49 · 2016: 38 · 2015: 36 · 2014: 42 · 2013: 47 · 2012: 29
FWCI
6.34
Type
journal article
Language
en
Open access
Locations
  • Twin Research (publishedVersion)
  • PubMed (publishedVersion)
  • VU Research Portal (publishedVersion, other-oa)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • AstraZeneca
  • EkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam)
  • Yrjö Jahnssonin Säätiö
  • Wellcome Trust (01254)
  • Chronic Disease Research Foundation
  • British Heart Foundation
  • European Commission (01254)
  • Academy of Finland (44069)
  • Norges Forskningsråd
  • National Institutes of Health
  • Medical Research Council
  • National Health and Medical Research Council
  • National Medical Research Council
  • Norwegian Institute of Public Health
  • National Institute on Alcohol Abuse and Alcoholism (AA00145, K05AA000145, R01AA008315, AA08315)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
body height, heritability, genetic architecture, twin studies, shared environment, nonshared environment, sex differences, cross-national comparison, additive genetic effects
MeSH terms
Adult, Australia, Body Height, Denmark, Female, Finland, United Kingdom, Humans, Italy, Male, Models, Genetic, Netherlands, Norway, Sweden

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