Recruitment of Older African Americans in Alzheimer's Disease Clinical Trials Using a Community Education Approach
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Abstract
Alzheimer's disease and related dementias (ADRD) is two times more prevalent among compared to non-Hispanic Whites. Despite the higher prevalence of ADRD among older African Americans, recent estimates suggest research enrollment by those who identify as African American remains limited. The purpose of the study is to 1) explore how a culturally tailored community education program impacts clinical trial interest and enrollment in ADRD research studies and to 2) identify how applicable the African American community perceived the culturally tailored curriculum. Using a community-engaged research approach, we collaborated with predominately African American serving community-based organizations to support content development and delivery of Aging with Grace (AWG), a culturally tailored ADRD educational curriculum. A total of five AWG presentations were given to 66 attendees. Most attendees (67%) expressed interest in participating in clinical trials after attending AWG. Enrollment increased within an observational study (84%) and lifestyle prevention clinical trials (52%) from 2018 to 2019. Attendees (32%) also perceived an increase in ADRD knowledge from attending AWG and 89.1% believed more African Americans should participate in research. Our work demonstrates the effectiveness of a culturally tailored community education program to enhance knowledge, clinical trial interest, and recruitment into observational studies and lifestyle ADRD clinical trials among older African Americans. Education programs developed in partnership with the community can serve as bridge to research participation for underrepresented minorities in clinical research. Future studies should assess long-term retention of knowledge and research readiness.
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There was a notion among some healthcare professionals that recruiting minority ethnic participants might be more cumbersome, demanding additional effort, time and resources.
“There was also a notion among some healthcare professionals that recruiting minority ethnic participants might be more cumbersome, demanding additional effort, time and resources [52, 59].”
From Enablers and barriers of clinical trial participation in adult patients from minority ethnic groups: a systematic review (2025) · cites this paper as [59]
The Introduction says some researchers labeled racial or ethnic minority groups “difficult to access” or “hard to reach,” and the Discussion describes a common perception that recruiting them into trials is difficult. The paper does not specify that healthcare professionals held this view or that recruitment was thought to require additional time and resources. (LLM, conf=0.85)
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- Authors
- Shaw, A. R., Perales-Puchalt, J., Moore, T., Weatherspoon, P., Robinson, M., Hill, C. V., & Vidoni, E. D.
- Affiliations
- University of Kansas (US)
- University of Kansas Medical Center (US)
- Alzheimer's Association (US)
- Corresponding author
- Vidoni, Eric D.
- Venue
- The Journal of Prevention of Alzheimer's Disease
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 9
- Issue
- 4
- Pages
- 672-678
- ISSN
- 2274-5807 (ISSN-L)
- PMC
- PMC9514712
- OpenAlex
- W4296658112
- Cited by
- 34
- References
- 51
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 6 · 2023: 6 · 2021: 1
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- The Journal of Prevention of Alzheimer s Disease (publishedVersion, cc-by-nc-nd)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (L60 AG069211, P30AG035982, K01AG072034, P30AG072973)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease and related dementias, clinical trial recruitment, African American older adults, culturally tailored education, community education, community organizations, community-engaged research, research participation, dementia knowledge, observational studies
- MeSH terms
- Alzheimer Disease, Black or African American, Health Education, Humans, Research Design
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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