Neural signature of behavioural inhibition in women with bulimia nervosa
Open accessAbstract
Background: Impaired inhibitory control is considered a behavioural phenotype in patients with bulimia nervosa. However, the underlying neural correlates of impaired general and food-specific behavioural inhibition are largely unknown. Therefore, we investigated brain activation during the performance of behavioural inhibition to general and food-related stimuli in adults with bulimia nervosa. Methods: Women with bulimia and healthy control women underwent event-related fMRI while performing a general and a food-specific no-go task. Results: We included 28 women with bulimia nervosa and 29 healthy control women in our study. On a neuronal level, we observed significant group differences in response to general no-go stimuli in women with bulimia nervosa with high symptom severity; compared with healthy controls, the patients showed reduced activation in the right sensorimotor area (postcentral gyrus, precentral gyrus) and right dorsal striatum (caudate nucleus, putamen). Limitations: The present results are limited to adult women with bulimia nervosa. Furthermore, it remains unclear whether impaired behavioural inhibition in patients with this disorder are a cause or consequence of chronic illness. Conclusion: Our findings suggest that diminished frontostriatal brain activation in patients with bulimia nervosa contribute to the severity of binge eating symptoms. Gaining further insight into the neural mechanisms of behavioural inhibition problems in individuals with this disorder may inform brain-directed treatment approaches and the development of response inhibition training approaches to improve inhibitory control in patients with bulimia nervosa. The present study does not support greater behavioural and neural impairments to food-specific behavioural inhibition in these patients.
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BN patients display low frontostriatal activity on cognitive control tasks including the Simon Spatial task and Go/No-Go.
“On task-based fMRI, BN patients display low frontostriatal activity on a number of cognitive control tasks, including the Simon Spatial task (Marsh et al., 2009b, 2011) and Go/No-Go (Skunde et al., 2016).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Skunde et al., 2016
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“On task-based fMRI, BN patients display low frontostriatal activity on a number of cognitive control tasks, including the Simon Spatial task (Marsh et al., 2009b, 2011) and Go/No-Go (Skunde et al., 2016).”
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- Authors
- Skunde, M., Walther, S., Simon, J. J., Wu, M., Bendszus, M., Herzog, W., & Friederich, H.-C.
- Affiliations
- Shanghai Normal University (CN)
- Venue
- Journal of Psychiatry and Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2016-09
- Volume
- 41
- Issue
- 5
- Pages
- E69-E78
- ISSN
- 1180-4882 (ISSN-L)
- 1488-2434
- PMC
- PMC5008924
- OpenAlex
- W2514872278
- Cited by
- 67
- References
- 57
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 11 · 2022: 9 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 1
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stryker
- Deutsche Forschungsgemeinschaft (FR 2626/ 3-1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- bulimia nervosa, behavioral inhibition, inhibitory control, dorsal striatum, sensorimotor cortex, binge eating, symptom severity, women
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Food, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Neuropsychological Tests, Psychomotor Performance, Visual Perception, Bulimia Nervosa
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