Cited by 240Cystic Fibrosis Research AdvancesBacterial biofilms and quorum sensingChronic Obstructive Pulmonary Disease (COPD) Research

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Changes in Cystic Fibrosis Airway Microbiota at Pulmonary Exacerbation

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Carmody, Lisa A., Zhao, Jiangchao, Schloss, Patrick D., Petrosino, Joseph F., Murray, Susan, Young, Vincent B., Li, Jun Z., LiPuma, John J.·2013·Annals of the American Thoracic Society

DOI 10.1513/annalsats.201211-107ocPMC PMC3960905

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Abstract

RATIONALE: In persons with cystic fibrosis (CF), repeated exacerbations of pulmonary symptoms are associated with a progressive decline in lung function. Changes in the airway microbiota around the time of exacerbations are not well understood. OBJECTIVES: To characterize changes in airway bacterial communities around the time of exacerbations and to identify predictors for these changes. METHODS: DNA prepared from 68 paired baseline and exacerbation sputum samples collected from 28 patients with CF were subjected to barcoded 16S rRNA gene pyrosequencing. Bacterial density was calculated by quantitative PCR. MEASUREMENTS AND MAIN RESULTS: Overall, significant differences in bacterial community diversity and bacterial density between baseline and exacerbation samples were not observed. However, considerable changes in community structures were observed in a subset of patients. In these patients, the dominant taxa and initial level of community diversity were significant predictors of the magnitude of community structure changes at exacerbation. Pseudomonas-dominant communities became more diverse at exacerbation compared with communities with other or no dominant species. The relative abundance of Gemella increased in 24 (83%) of 29 samples at exacerbation and was found to be the most discriminative genus between baseline and exacerbation samples. CONCLUSIONS: The magnitude of changes in the CF lung microbiota around the time of exacerbation was found to be largely dependent on community diversity and composition at baseline. Certain genera appear to play important roles in driving change in airway bacterial community composition at exacerbation. Gemella might play a direct role in and/or be a biomarker for pulmonary exacerbation.

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Authors: Carmody, L. A., Zhao, J., Schloss, P. D., Petrosino, J. F., Murray, S., Young, V. B., Li, J. Z., & LiPuma, J. J.
Affiliations: University of Michigan (US)
Microbiology and Immunology
Baylor College of Medicine (US)
Departments of Pediatrics and Communicable Disease and
Corresponding author: LiPuma, John J.
ORCID: Carmody, Lisa A.
Zhao, Jiangchao
Schloss, Patrick D.
Petrosino, Joseph F.
Murray, Susan
Young, Vincent B.
Li, Jun Z.
LiPuma, John J.
Venue: Annals of the American Thoracic Society
Publisher: Oxford University Press (OUP)
Published: 2013-06-01
Volume: 10
Issue: 3
Pages: 179-187
ISSN: 2325-6621 (ISSN-L)
2329-6933
DOI: 10.1513/annalsats.201211-107oc
PMC: PMC3960905
OpenAlex: W2129800212
Cited by: 239
References: 34
Citations by year: 2026: 4 · 2025: 10 · 2024: 12 · 2023: 19 · 2022: 19 · 2021: 19 · 2020: 23 · 2019: 22 · 2018: 18 · 2017: 28 · 2016: 17 · 2015: 30 · 2014: 15 · 2013: 3
FWCI: 17.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Annals of the American Thoracic Society (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Cystic Fibrosis Foundation
Georgia Clinical and Translational Science Alliance
National Institutes of Health (5rc1hl100809-02)
National Heart, Lung, and Blood Institute (U01HL098961, RC1-HL100809, 1RC1HL100809-01)
National Human Genome Research Institute (R01HG005975, R01HG004906)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034933)
National Center for Research Resources (UL1RR024986)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords: cystic fibrosis, pulmonary exacerbations, airway microbiome, bacterial community diversity, community composition, Pseudomonas, Gemella, biomarkers, lung function decline
MeSH terms: Adolescent, Adult, Child, Cystic Fibrosis, Female, Humans, Lung, Male, Middle Aged, Sputum, Disease Progression, Young Adult, Microbiota

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Changes in Cystic Fibrosis Airway Microbiota at Pulmonary Exacerbation

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