Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects
Open accessAbstract
The functional role of respiratory microbiota has attracted an accumulating attention recently. However, the role of respiratory microbiome in lung carcinogenesis is mostly unknown. Our study aimed to characterize and compare bilateral lower airway microbiome of lung cancer patients with unilateral lobar masses and control subjects. Protected bronchial specimen brushing samples were collected from 24 lung cancer patients with unilateral lobar masses (paired samples from cancerous site and the contralateral noncancerous site) and 18 healthy controls undergoing bronchoscopies and further analyzed by 16S rRNA amplicon sequencing. As results, significant decreases in microbial diversity were observed in patients with lung cancer in comparison to the controls, alpha diversity steadily declined from healthy site to noncancerous to cancerous site. Genus Streptococcus was significantly more abundant in cancer cases than the controls, while Staphylococcus was more abundant in the controls. The area under the curve of genus Streptococcus used to predict lung cancer was 0.693 (sensitivity = 87.5%, specificity = 55.6%). The abundance of genus Streptococcus and Neisseria displayed an increasing trend whereas Staphylococcus and Dialister gradually declined from healthy to noncancerous to cancerous site. Collectively, lung cancer‐associated microbiota profile is distinct from that found in healthy controls, and the altered cancer‐associated microbiota is not restricted to tumor tissue. The genus Streptococcus was abundant in lung cancer patients and exhibited moderate classification potential. The gradual microbiota profile shift from healthy site to noncancerous to paired cancerous site suggested a change of the microenvironment associated with the development of lung cancer.
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V. parvula has been previously linked to disease states and specifically enriched in the lung microbiome of patients with a primary lung malignancy.
“In addition. V. parvula has been previously linked to disease states and specifically enriched in the lung microbiome of patients with a primary lung malignancy (32–34).”
From A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors (2021) · cites this paper as [33]
Under certain conditions, Streptococcus gordonii can attack host fibronectin, and subsequent cytokine production can induce inflammatory responses.
“Under certain conditions, Streptococcus gordonii can attack host fibronectin, and subsequent cytokine production can induce inflammatory responses (Erb-Downward et al., 2011; Liu et al., 2018).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Liu et al., 2018
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- Authors
- Liu, H., Tao, L., Zhang, J., Zhu, Y., Zheng, Y., Liu, D., Zhou, M., Ke, H., Shi, M., & Qu, J.
- Affiliations
- Huadong Hospital Affiliated to Fudan University, No. 221, West Yan An Road Shanghai 200040 China
- UT Southwestern Medical Center, 6000 Harry Hines Blvd Dallas TX
- Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Tongji University (CN)
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2017-11-08
- Volume
- 142
- Issue
- 4
- Pages
- 769-778
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2765190797
- Cited by
- 235
- References
- 62
- Citations by year
- 2026: 21 · 2025: 40 · 2024: 24 · 2023: 34 · 2022: 33 · 2021: 34 · 2020: 28 · 2019: 15 · 2018: 6
- FWCI
- 18.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81401638)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- lung cancer, protected specimen brush, Streptococcus, Staphylococcus, Neisseria, Dialister, microbial diversity, lung carcinogenesis, tumor microenvironment, 16S rRNA gene sequencing
- MeSH terms
- Adult, Aged, Bronchoscopy, Female, Humans, Lung Neoplasms, Male, Middle Aged, Neisseria, Streptococcal Infections, Streptococcus, Case-Control Studies, Neisseriaceae Infections, Microbiota
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