The DOI matches its Crossref record; 160 of the 166 references it cites were found in a registry or an index.
Mitophagy: mechanisms, pathophysiological roles, and analysis
Open accessAbstract
Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury. Removal of damaged mitochondria through autophagy requires two steps: induction of general autophagy and priming of damaged mitochondria for selective autophagic recognition. Recent progress in mitophagy studies reveals that mitochondrial priming is mediated either by the Pink1-Parkin signaling pathway or the mitophagic receptors Nix and Bnip3. In this review, we summarize our current knowledge on the mechanisms of mitophagy. We also discuss the pathophysiological roles of mitophagy and current assays used to monitor mitophagy.
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“The PINK1/Parkin) pathway is among the best characterized pathways through which mitophagy is induced in mammalian cells[28]”
From Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster (2019) · cites this paper as [28]
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1 retracted
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
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RetractedAutophagy: Renovation of Cells and Tissues
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A role for mitochondria in nlrp3 inflammasome activation
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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Autophagy regulates lipid metabolism
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
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Cited by
Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Pathophysiology of type 2 diabetes mellitus
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176275 · Cited by 3,360
“The process of removing damaged mitochondria consists of two steps: the induction of general autophagy and the priming of damaged mitochondria for selective autophagy recognition [138].”
BackgroundGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
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Mitochondrial dynamics and mitochondrial quality control
Ni, H.-M., Williams, J. A., & Ding, W.-X. (2015) · Redox Biology · doi:10.1016/j.redox.2014.11.006 · Cited by 931
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Metadata
- Authors
- Ding, W.-X., & Yin, X.-M.
- Affiliations
- University of Kansas Medical Center (US)
- Indiana University School of Medicine (US)
- Venue
- bchm
- Publisher
- Walter de Gruyter GmbH
- Published
- 2012-07-01
- Volume
- 393
- Issue
- 7
- Pages
- 547-564
- ISSN
- 1431-6730 (ISSN-L)
- 1437-4315
- PMC
- PMC3630798
- OpenAlex
- W2076769172
- Cited by
- 1,032
- References
- 166
- Citations by year
- 2026: 47 · 2025: 77 · 2024: 83 · 2023: 99 · 2022: 90 · 2021: 115 · 2020: 111 · 2019: 98 · 2018: 67 · 2017: 64 · 2016: 59 · 2015: 44 · 2014: 50 · 2013: 25 · 2012: 1
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- National Institutes of Health (AA020518, RR016475)
- National Institute on Alcohol Abuse and Alcoholism (R01AA020518, R21AA017421, R37AA020518)
- National Cancer Institute (R01CA83817, R01CA083817)
- National Institute of General Medical Sciences (P20GM103418)
- National Center for Research Resources (P20RR021940, RR016475, P20RR016475)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitophagy, PINK1/Parkin pathway, Nix, BNIP3, mitochondrial priming, selective autophagy, neurodegenerative diseases, ischemia, energy homeostasis, cell death
- MeSH terms
- Aging, Animals, Disease, Humans, Mitochondria, Signal Transduction, Mitochondrial Proteins, Mitophagy
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